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조주현 ( Ju Hyun Jo ),오창근 ( Chang Keun Oh ),김문범 ( Moon Bum Kim ),장호선 ( Ho Sun Jang ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.2
Background: Varicose vein is the most common venous disease of the lower extremities. The treatment of varicose vein is commonly performed for cosmetic improvement, although most patients are symptomatic as well. Sclerotherapy is a useful adjunct to large
악성 흑색종에서의 p16 , p53 , Ki - 67 및 factor 8 연관 항원의 발현과 예후와의 관련성에 관한 연구
조주현(Ju Hyun Jo),김문범(Moon Bum Kim),오창근(Chang Keun Oh),장호선(Ho Sun Jang),권경술(Kyung Sool Kwon) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.7
N/A Background : Biologic markers such as the p16 protein, p53 protein and Ki-67 antigen, as well as factor Ⅷ-related antigen have been explored in various malignancies as potential prognostic factors. Objective : The aims of this study are to examine the expression of biologic markets and to assess their correlation with conventional clinicopathological prognostic factors in malignant melanoma. Methods : Immunohistochemical stains for p16, p53, Ki-67 and factor Ⅷ-related antigen were performed in twenty formalin-fixed, paraffin-embedded tissues of primary and metastatic malignant melanomas. We compared the expression of biologic markers with conventional clinicopathologic factors, such as the presence of metastasis, ulceration, Breslow thickness, Clark level and American Joint Commission on Cancer(AJCC) TNM staging. Results : Loss of p16 expression was significantly higher for the metastatic melanomas(90%) than the nonmetastatic(50%). But the results were not correlated with the clinicopathologic prognostic factors. The p53 expression was found in 7/10(70%) of the metastatic melanomas and in 3/10(30%) of the primary melanomas. Statistically, p53 expression was positively correlated with Breslow thickness(p=0.017), Clark level(p=0.003) and TNM staging(p=0.009). Furthermore, statistically significant trends were observed towards increasing expression of Ki-67 with metastatic dissemination(p=0.014), increasing Breslow thickness(p=0.008), Clark level(p=0.012) and TNM staging(p=0.009). Positive correlation was present between TNM staging and factor Ⅷ-related antigen expression(p=0.014). Conclusion : p53 protein and Ki-67 antigen may be more useful independent predictors than p16 protein and factor VIII-related antigen in Korean patients with malignant melanoma.
동형접합성 단백 C 결핍에 의한 신생아 전격성 자반증 1 예
조주현(Ju Hyun Jo),오창근(Chang Keun Oh),김문범(Moon Bum Kim),장호선(Ho Sun Jang),권경술(Kyung Sool Kwon) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.1
Homozygous protein C deficiency is a rare hereditary coagulation disorder that occurs most often in childhood and is characterized by widespread thrombosis of capillaries and venules, abrupt onset of ecchymoses and necrosis. The hematological feature corresponds with disseminated intravascular coagulation. Protein C is a natural anticoagulant and also has important anti-inflammatory activity. For confirmation of homozygous protein C deficiency, the infant should have undetectable protein C activity and both parents should be heterozygous for protein C deficiency. We experienced a case of purpura fulminans in the newborn infant in whom we identifed homozygosity for familial protein C deficiency. Fresh frozen plasma for replacement of protein C, early debridement and full-thickness skin graft induced a remission. Administration of warfarin was used to prevent recurrence of attacks. This report emphasizes the need for early diagnosis and adequate replacement therapy in patient with purpura fulminans. (Korean J Dermatol 2002;40(1):38~43)
김屬(Porphyra) 3種의 패각사상체 성숙 및 채묘에 미치는 조도의 영향
김영종(Young Jong KIM),조주현(Ju Hyun JO),최성제(Sung Je CHOI),신종암(Jong Ahm SHIN) 전남대학교 수산과학연구소 1999 수산과학연구소논문집 Vol.8 No.-
To advance seeding of conchospores of Porphyra dentata, P. seriata and P. tenera, the effects of light intensity and photoperiod on growth of shell-inhabiting conchocelis, and formation and maturation of conchosporangia were studied from May to October in 1998. Growth of shell-inhabiting conchocelis of these species was similar to one another in early culture under natural light intensity, photoperiod and room temperature; growth of P. dentata and P. seriata was higher than that of P. tenera at 800 lux from August to September; growth of these three species was similar to one another at 800 lux in October. The color of shell-inhabiting conchocelis of P. dentata and P. seriata was red and the color of P. tenera black, but all the species were reddish-purple after mid-september. Formation rate of conchosporangia was 90% or more in P. tenera, 70% in P. seriata and less than 40% in P. dentata at September. Maturation of conchosporangia under 500 and 800 lux was better than 1,500 lux in the three species. Numbers of released conchospores were more at 18℃ than at 22℃, and the short-day treatment(8L:16D) gave rise to promotion of conchospore release. Numbers of conchospore germlings attached 1 ㎝ long netting-twine after 30 days of seeding were 35 individuals in P. tenera, 10 individuals in P. seriata and 3 individuals in P. dentata. Attached germlings of P. seriata were increased after 45 and 60 days; it suggests that monospores might be released
조정민(Jeong-Min Jo),한영재(Young-Jae Han),이창영(Chang-Young Lee),조주현(Ju-Hyun Cho),최성호(Seong-Ho Choi) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.10
LSMs are installed under girders along the long track. In order to improve the efficiency of the LSM long stator LSM should be divided into the specified length and the propulsion inverters should have the system topology to generate high voltage and current for LSMs. This paper presents a system topology with two-step inverter in order to generate high voltage in inverter. A LSM propulsion system is developed and implemented in Maltab/Simulink. A system model of the two-step Inverter is applied to developed model. This paper demonstrates through simulation advantages of multi-step inverter. The conclusions can serve the design of LSM propulsion system.
정도상 ( Do Sang Jung ),조주현 ( Ju Hyun Jo ),오창근 ( Chang Keun Oh ),장호선 ( Ho Sun Jang ),권경술 ( Kyung Sool Kwon ),남상욱 ( Sang Ook Nam ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11
Menkes syndrome is a rare fatal neurodegenerative disease with X-linked recessive inheritance. The clinical characteristic features are progressive neurological disturbances, arterial degeneration, connective tissue and hair abnormalities. This syndrome is a disorder of copper transport caused by mutations in a gene for a copper-transporting P-type ATPase. We have experienced a case of Menkes syndrome in an eight-month old male patient, who manifested seizure, developmental delay and characteristic pili torti. He was diagnosed by clinical features, laboratory tests such as low serum copper and ceruloplasmin level, cerebral atropy in brain magnetic resonance(MR) image and arterial abnormality in MR angiography. We review literatures and describe the distinctive features of this rare disorder.