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신상철,조정원 ( Sang Chul Shin,Cheong Weon Cho ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A Nicotinic acid was mixed with glass powders such as controlled pore glass (CPG), glyceryl controlled pore glass (GPG) and glass beads (GB) at room temperature. The physicochemical properties of nicotinic acid in the various mixtures were examined by differential thermal analysis. X-ray diffraction study. Infrared spectroscopy and BET gas adsorption measurements. The peak area at the melting point from the various mixtures of nicotinic acid and CPG was increased with an increase of nicotinic acid concentration while the broad peak area was remained unchanged in the DTA curve. As shown in the powder X-ray diffraction patterns, the crystalline peaks of nicotinic acid disappeared in mixture with CPG, suggesting the interaction of nicotinic acid and porous powders. It was found that the larger the content of CPG, the higher the ratio of an amorphous state to a crystalline state. BET isotherm showed that as the amount of nicotinic acid was increased, the specific surface area was reduced proportionally to nicotinic acid content of up to 40% and remained constant thereafter. Sublimation of nicotinic acid from the mixture of nicotinic acid and CPG was examined. A large quantity of nicotinic acid was retained in the mixture when stored on various temperatures in vacuo for 10 hours. The nicotinic acid mixtures with CPG or GPG showed a high dissolution rates of nicotinic acid in aqueous solution, especially in the initial dissolution stage. CPG is expected to be a good pharmaceutical excipient to reduce the crystallinity of drugs and to prevent sublimation of drugs.
주홍매,김정숙,박경래,조정원,김영섭,김정우,유시용,강종성,Zhu, Hong-Mei,Kim, Jung-Sook,Park, Kyung-Lae,Cho, Cheong-Weon,Kim, Young-Sup,Kim, Jung-Woo,Ryu, Shi-Yong,Kang, Jong-Seong 대한약학회 2009 약학회지 Vol.53 No.2
Quantitative analysis of (+)-catechin (C), (-)-epigallocatechin (EGC), (-)-epicatechin (EC), (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG) and caffeine in commercial green tea was carried out by HPLC employing gradient elution of 0.1% acetic acid and acetonitrile on ODS column. The optimized HPLC method provided satisfactory linearity, accuracy and precision. The relationship between the concentration of the components and cultivated region of the commercial green tea was not significant, while the concentration of EGCG, ECG and caffeine decreased significantly in the later harvested green tea samples (p<0.01). Multivariate analysis of the components was performed in order to characterize and evaluate the cultivated region and harvest period-related variation. Hierarchical clustering and discriminant analysis were applied to classify the geographical and seasonal origins of the green tea samples. The classification accuracy of the cultivated region and harvest period by discriminant analysis was 95% and 91%, respectively, indicating that this method could be reliable and convenient for the quality control of herbal products with different origin.
생기액(生肌液)의 세포독성 및 자궁경부암 바이러스 (HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과
정옥(Ok Joung),조영식(Young Sik Cho),조정원(Cheong Weon Cho),이경애(Kyung Ae Lee),심정현(Jung Hyun Shim),조민철(Min Chul Cho),이홍수(Hong Soo Lee),염영일(Young Il Yeom),김상범(Sang Bom Kim),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2000 약학회지 Vol.44 No.4
Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner. In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.
이상길 ( Sang Gil Lee ),신진선 ( Jin Sun Shin ),조정원 ( Cheong Weon Cho ),손윤희 ( Yun Hee Shon ),남경수 ( Kyung Soo Nam ) 한국키틴키토산학회 2010 한국키틴키토산학회지 Vol.15 No.4
저분자 키토산 올리고당(Mw<1,000)의 사람 직장암세포 HT-29에서의 QR과 GST의 활성 및 GSH 생성 유도효과와 ODC 활성에의 영향을 측정한 결과, 저분자 키토산 올리고당은 phase Ⅱ 생체 해독효소인 QR과 GST의 활성 증가 및 GSH 함량을 증가시켰으므로 직장암발생(colon cancer carcinogenesis)의 개시단계(initiation)를 저해할 수 있을 것으로 보인다. 또한 직장암 발생과정의 촉진단계(promotion)에 관여하는 ODC 활성도 저해하였으므로 저분자 키토산 올리고당은 직장암 발생의 개시단계와 촉진단계에 저해효과가 있을 가능성이 높다. 그러므로 저분자 키토산 올리고당은 직장암 발생과정에 관련된 더 많은 연구를 통하여 직장암발생 억제물질로서 개발 가능성이 있는 것으로 보인다. The effect of low molecular weight chitosan oligosaccharide (Mw<1,000) on colon cancer carcinogenesis was investigated by measuring quinone reductase (QR), glutathione S-transferase (GST) and 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ornithine decarboxylase (ODC) activities and glutathione (GSH) levels. Chitosan oligosaccharide induced QR activity in a dosedependent manner in a concentration range of 0.1~5.0 mg/mL. In addition GST activity was increased with chitosan oligosaccharide in cultured human colorectal adenocarcinoma HT-29 cells. The content of GSH was increased by the treatment of chitosan oligosaccharide. Chitosan oligosaccharide inhibited ODC activity, a key enzyme of polyamine biosynthesis. These results imply that low molecular weight chitosan oligosaccharide may suppress colon cancer carcinogenesis by increasing QR and GST activities and GSH content by inhibiting ODC activity.