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데스메막박리 자동각막내피층판이식술 후 발생한 단순포진바이러스 각막염 1예
정세형,조재갑,윤경철,Se Hyeong Jeong,MD,Jae Kap Cho,MD,Kyung Chul Yoon,MD 대한안과학회 2012 대한안과학회지 Vol.53 No.3
Purpose: To report a case of herpes simplex keratitis after descemet stripping automated endothelial keratoplasty (DSAEK). Case summary: A 66-year-old male underwent DSAEK in his right eye due to bullous keratopathy after cataract surgery. The corneal epithelium which was removed during surgery was healed, but the patient was experiencing pain and decreased visual acuity in his right eye 1 month after surgery. Increasing corneal epithelial defects and corneal edema were observed on slit-lamp examination. Therapeutic soft contact lenses and artificial tears were used for treatment but were not effective, thus amniotic membrane transplantation was performed. Three months after transplantation, the epithelial defect appeared as a geographic ulcer suspecting to be herpes simplex keratitis; therefore, ganciclovir ophthalmic ointment and oral acyclovir were administered. Six months after antiviral therapy, the epithelial lesion of herpes simplex keratitis completely disappeared, leaving only mild corneal opacity. Conclusions: If corneal epithelial defects are persistent after DSAEK in patients even with no past history of herpes simplex keratitis, herpes simplex keratitis should be considered in the differential diagnosis. J Korean Ophthalmol Soc 2012;53(3):473-477
기존 치료에 반응하지 않는 진균 각막염에서 전방내 보리코나졸 주입술의 임상 효과
정세형,이효석,조재갑,윤경철,Se Hyeong Jeong,MD,Hyo Seok Lee,MD,Jae Kap Cho,MD,Kyung Chul Yoon,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.5
Purpose: To evaluate clinical effects of intracameral voriconazole injection in fungal keratitis refractory to conventional therapy. Methods: Thirty-eight eyes of 38 patients with fungal keratitis were included in this study. The patients were divided into 3 groups: 13 patients with intracameral voriconazole injection (50 μg/0.1 ml; group A), 11 patients with intracameral amphotericin B injection (10 μg/0.1 ml; group B), and 14 patients with conventional therapy only (group C). Clinical factors including treatment success rate and time to successful treatment were evaluated. Results: Treatment success was accomplished in 12 eyes in group A (92.3%), 10 eyes in group B (90.9%), and 12 eyes in group C (85.7%). Time to treatment success in group A, B, and C was 36.1 ± 10.4 days (p = 0.04), 34.2 ± 7.8 days (p = 0.03), and 49.5 ± 16.7 days, respectively. Patients who had received intracameral voriconazole injection or amphotericin B showed faster fungal keratitis improvement than patients who received conventional treatment. Time to re-epithelialization and time to disappearance of hypopyon showed a similar clinical course. Conclusions: Intracameral voriconazole injection, which has a similar therapeutic effect as intracameral amphotericin B injection in the management of fungal keratitis, can be helpful in the treatment of intractable fungal keratitis.
건성안을 동반한 갑상샘안병증에서 0.05% 사이클로스포린 A 점안액 사용 후 눈물막과 안구표면의 변화
최원,박영걸,조재갑,윤경철,Won Choi,Yeoung-Geol Park,Jae-Kap Cho,Kyung-Chul Yoon 대한안과학회 2010 대한안과학회지 Vol.51 No.10
Purpose: The present study was performed to evaluate the changes in tear film and ocular surface parameters after using sodium hyaluronate (SH) 0.1% alone or in combination with cyclosporine A (CsA) 0.05% in patients with thyroid- associated ophthalmopathy accompanied by dry eye. Methods: A total of 72 eyes from 36 patients were divided into two groups; 36 eyes of 18 patients were treated with 0.1% SH alone (group 1), and 36 eyes of 18 patients were treated with SH 0.1% and CsA 0.05% (group 2). Tear break-up time (BUT), basal tear secretion test (BST), tear clearance rate (TCR), fluorescein staining (FS) and corneal sensitivity test (CST) were evaluated at pre-treatment and one, three and six months post-treatment. Conjunctival impression cytology was performed and tear CXCL11 (Chemokine (C-X-C motif) ligand) levels were measured pre-treatment and three months post-treatment. Results: BUT, BST, TCR, KEP and CST were significantly improved at six months in group 1 (p < 0.05) and at three months in group 2 (p < 0.05). The degree of conjunctival squamous cell metaplasia, goblet cell density and tear CXCL11 levels were significantly changed at three months in group 2 (p < 0.05). However, there were no significant changes in group 1 after 3 months. Conclusions: Combined use of topical 0.1% SH and 0.05% CsA can result in early improvement in tear films and ocular surface parameters in patients with thyroid-associated ophthalmopathy accompanied by dry eye. J Korean Ophthalmol Soc 2010;51(10):1319-1326
기상청 현업 모델 RDAPS와 QuikSCAT 해상풍 자료의 비교
유승협(You, Sung-Hyup),조재갑(Cho, Jae-Gab),서장원(Seo, Jang-Won) 한국해안해양공학회 2007 한국해안해양공학회 논문집 Vol.19 No.5
기상청 현업 모델 RDAPS 모델 자료와 QuikSCAT 관측결과 중 2005, 2006년 해상풍 자료를 비교하였다. 해상풍의 하계와 동계의 평균 공간 분포의 분석결과 한반도 주변의 계절적인 해상풍의 뚜렷한 특성을 잘 나타낸다. 모델과 관측의 해상풍 통계 분석 비교에서도 계절적인 차이를 잘 나타낸다. 한반도 주변의 하계 BIAS 값은 -0.5m/s이하의 분포를 보이고, 동계에는 -1 m/s이하의 분포를 보인다. 상관계수의 경우 하계에는 0.7, 동계에는 0.8 이상으로 분포한다. 공간적으로 평균된 상관계수의 경우 2005년, 2006년 모두 하계보다 동계에 더욱 상관관계가 높은 것으로 나타났다. 이것은 하계의 약한 풍속보다 동계의 강한 해상풍을 RDAPS에서 더 잘 재현하고 있는 것으로 판단된다. This study compared the sea surface wind pattern between model results from KMA operational model (RDAPS) and observational results from QuikSCAT in the 2005-2006 year. The mean spatial distributions of sea surface wind show the prominent seasonal patterns of summer and winter season adjacent to Korean Peninsular. The statistical analysis also shows well seasonal variation of sea surface wind patterns between model and observation results. The BIAS value represents less than -0.5 m/s and -1 m/s in summer and winter seasons, respectively. The spatially averaged correlation coefficient shows larger than 0.7 and 0.8 in summer and winter seasons, respectively. The correlation coefficient of winter season shows higher value than that of summer season in the comparison between model and observation. This results show that the RDAPS model simulate well strong sea surface wind in winter season rather than weak sea surface wind in summer season.