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MRI Features of Hepatocellular Carcinoma Related to Biologic Behavior
조은석,최진영 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3
Imaging studies including magnetic resonance imaging (MRI) play a crucial role in the diagnosis and staging of hepatocellular carcinoma (HCC). Several recent studies reveal a large number of MRI features related to the prognosis of HCC. In this review, we discuss various MRI features of HCC and their implications for the diagnosis and prognosis as imaging biomarkers. As a whole, the favorable MRI findings of HCC are small size, encapsulation, intralesional fat, high apparent diffusion coefficient (ADC) value, and smooth margins or hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI. Unfavorable findings include large size, multifocality, low ADC value, non-smooth margins or hypointensity on hepatobiliary phase images. MRI findings are potential imaging biomarkers in patients with HCC.
두록의 동결정액의 운동학적 특성과 ESR1 유전자의 SNP(g.35756T>C)와 연관성 분석
조은석,김기현,우제석,이미진,김영주,사수진 사단법인 한국동물생명공학회 2015 한국동물생명공학회지 Vol.30 No.3
Cryopreservation of boar semen is continually researched in reproductive technologies and genetic resource banking in breed conservation. For evaluating the boar semen quality, sperm motility (MOT) is an important parameter because the movement of spermatozoa indicates active metabolism, membrane integrity and fertilizing capacity. Various researches have been trying to improve the quality of semen Post-thawed in boar. Recently, polymorphism (g. 35756 T>C) of Estrogen Receptor 1 (ESR1) gene reported to be significant association with MOT. This study was conducted to evaluate the ESR1 gene as a positional controlling for motility and kinematic characteristics of post-thawed boar semen. To results, The g.35756 T>C SNP of ESR1 was significantly associated with frozen semen motility and kinematic characteristics. The g.35756 T>C SNP was high significantly associated with MOT, VCL, VSL and VAP (p<0.001). The SNP was also significantly associated with ALH (P<0.05). Therefore, we suggest that the g. 35756 T>C polymorphism in the intron 1 region of the porcine ESR1 gene could potentially be applied in frozen semen programs to improve MOT trait, but only after validation in other populations.
조은석,윤석호,김민수 대한설비공학회 2002 설비공학 논문집 Vol.14 No.1
Evaporative heat transfer characteristics of carbon dioxide have been investi- gated by experiment. The experiments have been carried out for a seamless stainless steel tube of the outer diameter of 9.55 mm, the inner diameter of 7.75 mm and the length of 5.0 m. Direct heating method was used for supplying heat to the refrigerant where the test tube was uniformly heated by electric current which was applied to the tube wall. Experiments were conducted with$CO_2$of purity 99.99% at saturation temperatures of 0.0 to 10.5$^{\circ}C$, heat fluxes of 12 to 27kW/$m^2$s and mass fluxes of 212 to 530 kg/$m^2$s. The heat transfer coefficients of $CO_2$are decreased as the vapor quality increases and these phenomena are explained by dimensionless Weber and Bond numbers. The heat transfer coefficients of$CO_2$increase when the heat and mass fluxes increase, and the saturation temperature effects are minor in the test range of this study. The present experimental data are compared with six renowned correlations with root-mean-squared deviations ranging from 23.0 to 94.9% respectively.
조은석,정재준,김성준,김주희,유정식,윤춘식 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.2
Objective: To investigate the validity of the 100 kVp setting in CT venography (CTV) in the diagnosis of deep vein thrombosis (DVT), and to evaluate the feasibility of reducing the amount of administered iodine in this setting. Materials and Methods: After receiving the contrast medium (CM) of 2.0 mL/kg, 88 patients underwent CTV of the pelvis and lower extremities by using one of four protocols: Group A, 120 kVp setting and 370 mgI/mL CM; group B, 120 kVp and 300 mgI/mL; group C, 100 kVp and 370 mgI/mL; group D, 100 kVp and 300 mgI/mL. The groups were evaluated for venous attenuation, vein-to-muscle contrast-to-noise ratio (CNRVEIN), DVT-to-vein contrast-to-noise ratio (CNRDVT), and subjective degree of venous enhancement and image quality. Results: Venous attenuation and CNRVEIN were significantly higher in group C (144.3 Hounsfield unit [HU] and 11.9), but there was no significant difference between group A (118.0 HU and 8.2) and D (122.4 HU and 7.9). The attenuation value of DVT was not significantly different among the four groups, and group C had a higher absolute CNRDVT than the other groups. The overall diagnostic image quality and venous enhancement were significantly higher in group C, but there was no difference between groups A and D. Conclusion: The 100 kVp setting in CTV substantially help improve venous enhancement and CNRVEIN. Furthermore, it enables to reduce the amount of administered iodine while maintaining venous attenuation, as compared with the 120 kVp setting.