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조영일,Jong-Hyun Park,Chul-Won Lee,라원희,정종욱,Jung-Ro Lee,Kyung-Ho Ma,Seok-Young Lee,Kang-Seob Lee,Myung-Chul Lee,Yong-Jin Park 한국유전학회 2011 Genes & Genomics Vol.33 No.2
Sixteen polymorphic microsatellite (SSR) markers, developed from an SSR-enriched genomic DNA library of sesame (Sesamum indicum L.), were used to assess genetic diversity,phylogenetic relationships, and population structure among 150 sesame accessions collected from 22 countries. A total of 121 alleles were detected among the sesame accessions. The number of detected alleles varied from 2 to 18, with an average of 7.6 alleles per locus. Polymorphism information content values ranged from 0.03 to 0.79, with an average of 0.42. These values indicated an excess of heterozygous individuals at 16 loci and an excess of homozygous individuals at three loci. Of these, 32 genotype-specific alleles were identified at 11 of 16 polymorphic SSR markers. Cluster analyses were performed by accession and population, revealing a complex accession distribution pattern with mean genetic similarity coefficient of 0.45 by accession and 0.52 by population. The wide variation in genetic similarity among the accessions revealed by SSRs reflected a high level of polymorphism at the DNA level. Model-based structure analysis revealed the presence of three groups that were basically consistent with the clustering results based on genetic distance. These findings may be used to augment the sesame germplasm and to increase the effectiveness of sesame breeding.
복막투석 중인 말기신부전 환자에서 지속적인 midazolam 정주에 의한 진정 상태의 지연 회복
조영일 ( Young Il Jo ),최혜진 ( Hye Jin Choi ),김소영 ( So Young Kim ),최혜진 ( Hae Jin Choi ),박현식 ( Hyun Sik Park ),윤선웅 ( Seon Ung Yun ),배병주 ( Byeong Joo Bae ),박정환 ( Jung Hwan Park ),이종호 ( Jong Ho Lee ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
Purpose: Midazolam, a benzodiazepine derivatives, is widely used in intensive care unit for sedation of patients who require mechanical ventilation. Although midazolam has a short acting time, it might cause a prolonged sedation, especially in patients with renal failure. We report the case of a 76-year-old man who received peritoneal dialysis and showed prolonged sedation after stopping continuous infusion of midazolam. The patient who has received maintenance hemodialysis for five months admitted in intensive care unit to manage pneumonia and severe congestive heart failure. In ICU, hemodialysis was transferred to peritoneal dialysis due to severe cardiac dysfunction. He was treated with mechanical ventilation under sedation with midazolam. However, even though stopping midazolam, deep sedation by midazolam was not restored. The patient completely recovered from sedation after 280 hours.
혈액투석 환자에서 저용량 Megestrol Acetate 복용이 영양학적 지표에 미치는 영향
박정환 ( Jung Hwan Park ),이은 ( Eun Lee ),조영일 ( Young Il Jo ),송종오 ( Jong Oh Song ),이종호 ( Jong Ho Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4
Purpose: Maintenance hemodialysis (HD) patients have a high prevalence of malnutrition and inflammation. Megestrol acetate (MA) has been shown to increase appetite in cancer patients but the usual dose of MA (400-800 mg/day) was associated with serious side effects in HD patients. We evaluated the changes in nutritional and inflammatory parameters after low dose of MA treatment in malnourished HD patients. Methods: Inclusion criteria were maintenance HD patients who showed serum albumin <3.5 g/dL or <4.0 g/dL with anorexia. Serum chemical parameters, cytokines, Subjective Global Assessment, dry weight, Kt/V, nPCR, SF36 quality of life, fat free mass (FFM), and body fat mass (BFM) were measured. Patients were instructed to take 5 mL (200 mg) of MA solution once a day. Results: Fourteen patients (seven male, age 52±10 years, mean HD duration 48±59 months) were included. One patient died of pneumonia. Seven patients dropped out because they refused to take the drug after one to three months of treatment; two of them complained of thirst, three of them ate too much, and two had both. Six patients (four male and two female) have completed six months of study. Serum albumin (3.1±0.5 to 3.6±0.4 g/dL), TIBC (184.2±27.9 to 205.0±25.8 ug/dL), BFM (11.9±5.7 to 16.6±7.4 kg), protein intake (57.0±32.5 to 68.7±39.2 g/day), and energy intake (1,521±690 to 1,724±879) were increased. Serum CRP and IL-6 decreased without statistical significance. No significant adverse effects were observed in all patients who had completed study. Conclusion: Low dose MA can improve the nutritional status, inflammation, and anorexia in maintenance HD patients.