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유방암 환자에서 항암화학요법 후 인지기능과 후각기능의 변화 : 예비연구
임종석(Jongseok Lim),고수진(Su-Jin Koh),조수현(Soohyun Joe) 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.2
Objectives:This study evaluated olfactory identification performance and cognitive impairment following chemotherapy in patients with breast cancer. Methods:A total of 18 patients with breast cancer who were treated with chemotherapy were included in this study. The patients were evaluated for mental status, cognitive function, and olfactory identification performance before chemotherapy and 6 months after chemotherapy. Paired t-tests were used to examine the differences in scores before and after chemotherapy sessions. Results:No statistically significant differences were found in the scores of subjective cognitive function and olfactory identification performance pre- and post- chemotherapy. None of the objective cognitive function test scores declined at 6 months after chemotherapy. Mean scores of word list delayed recall(p=0.011), trail making A(p=0.026), symbol search(p=0.032), and modified Stroop test(p=0.002) showed significant improvement after chemotherapy. Among them, modified Stroop test score showed statistically significant improvement after Bonferroni correction. Conclusion:Olfactory and subjective cognitive functions of patients were not impaired 6 months after chemotherapy. However, some cognitive function related to execution improved 6 months after chemotherapy. These improvements in cognitive function after chemotherapy could be due to either a practice effect, recovery from acute stress due to cancer treatment, or an anti-inflammatory effect of chemotherapy. It is necessary to study the persistence of this pattern of cognitive improvement in long term follow-up.
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메스암페타민 의존 환자에서 바이오피드백 훈련의 효과 : 정량화 뇌파를 이용한 예비연구
박창교(Changkyo Park),권도훈(Dohoon Kwon),조성남(Sungnam Cho),김양태(Yangtae Kim),김기성(Kiseong Kim),조수현(Soohyun Joe) 한국중독정신의학회 2012 중독정신의학 Vol.16 No.2
Objectives : In this study, authors investigated the neurophysiological effect of biofeedback training in patients with meth-amphetamine dependence using quantitative EEG (qEEG). Methods : Methamphetamine-dependent patients willing to receive biofeedback therapy were recruited in an addiction ward. qEEG measurements were conducted before and after each training session. Theta (4-8 Hz) relative power was measured and com-pared before and after biofeedback qEEG of each session. Results : A total of 49 pairs of relative power before and after bio-feedback qEEGs were obtained from 11 subjects with methamphetamine dependence. The right temporal theta relative power showed a significant decrease after biofeedback training. The right frontal theta relative power in the early biofeedback train-ing sessions showed a significant decrease compared with the later training sessions. Additionally, the right temporal theta relative power after the last-biofeedback training session also showed a significant decrease compared with the biofeedback before the first training session. Conclusion : These results suggested that the application of biofeedback training program changed brain waves and thus, could be a useful method of treat-ment for methamphetamine dependence.
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