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품질 보증을 위한 멸균법이 목단피의 패오놀 함량에 미치는 영향
이용수,신운섭,조소연,제금련,이효민,정춘식,Lee, Yong-Soo,Shin, Woon-Seob,Cho, So-Yean,Ze, Keum-Ryon,Lee, Hyo-Min,Jeong, Choon-Sik 대한약학회 2005 약학회지 Vol.49 No.2
The purpose of this study was to develop the best methods to sterilize Moutan Root Bark which is frequently used as a herbal medicine, and known to have high susceptibility to m icrobial contamination. We used dry heat, gamma irradiation and alcohol gas treatment for sterilization, and evaluated these methods in terms of the followings; I) the efficacy of sterilization, and ii) the chemical alteration of a major component of the harbal medicines. Treatment with dry heat effectively got rid of contaminated microorganisms, and did not significantly alter the content of paeonol. However it seriously changed the color and morphology which are an essential criterion to estimate a measure of quality of medicinal herbs. Treatment with gamma irradiation showed a strong sterilizing effect, and no alteration of the content of paeonol, color and morphology. Alcohol gas treatment resulted in similar effects as those in gamma irradiation. Collectively, these results suggest that appropriate sterilizing methods to guarantee the microbial quality of this herbal medicine may be those using gamma irradiation or alcohol gas.
품질 보증을 위한 멸균법이 수종 생약의 지표성분 함량에 미치는 영향
정춘식(Choon Sik Jeong),조소연(So Yean Cho),이용수(Yong Soo Lee) 대한약학회 2006 약학회지 Vol.50 No.6
The purpose of this study was to develop the best methods to sterilize herbal medicines which is frequently used and known to have high susceptibility to microbial contamination. We used dry heat, gamma irradiation and alcohol gas treatment for sterilization, and evaluated these methods in terms of the iollowings; ⅰ) the efficacy of sterilization, and ⅱ) the chemical alteration of index constituents of herbal medicines. Treatment with dry heat effectively eliminated the contaminated microorganisms, and did not significantly alter the content of berberine chloride, paconiflorin and amygdalin in Phellodendron Bark, Peony Root and Apricot Kernel, respectively. However, it seriously changed the color and morphology which are essential criteria to estimate a measure of quality of herbal medicines. Treatment with gamma irradiation showed a strong sterilizing effect, and no alteration of the content of index constituents, color and morphology. Alcohol gas treatment resulted in similar effects as those in gamma irradiation. Collectively, these results suggest that treatment with gamma irradiation or alcohol gas may be useful methods for sterilizing herbal medicines without a decrease in their micorbial quality.