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위내시경으로 진단된 Gastric Red Spots(GRS)의 병태생리 및 임상적 의의
박경남,이민호,강인구,양석철,조석신,함준수,이종철,기춘석,성인경 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5
The incidence of GRS in the proximal part of the stomach was investigated in patients with various liver diseases. 477 patients with biopsy proven chronic liver disease underwent endoscopic study and GRS were obaerved in 38 (20.3%) out of 187 patients with liver cirrhosis, in 21 (16.8%) out of l25 patients with chronic active hepatitis, in 9 (15. 5%) out of 58 patients with chronic persietent hepatitis, and in 12 (14.3%) out of 84 patients with other chronic liver pathologies. There were no statistical differences among the groups. The incidence of chronic liver disease among patients with normal liver function tests and abdominal ultrasonography, but exhibiting GRS upon endoscopic study, was also prospectively studied by liver biopsy. 11 of 23 such patients had chronic liver disease: 2 had liver cirrhosis, 3 with chronic persistent hepatitis, and 6 with chronic reactive hepatitis, while 12 patients with no conclusive pathology in liver biopsy in spite of minimal disarray of hepatic lobular architecture and mild inflammatory cell infiltration into periportal area. The heart to liver radioisotope uptake ratios measured by Thallium-201 scan to estimate the portal pressure were 13±3% (mean± SD) in 15 control subjects, 22±7% in 20 patients with chronic persistent hepatitis, 28±13% in 15 patients with chronic active hepatitis, 59±41% in 18 patients with liver cirrhosis, and 27±14% in 50 patients with GRS, but with normal liver function test results and normal abdomial ultrasonography. These results showed statistical difference from normal control (p$lt;0.05). It can thus be concluded that GRS in the proximal part of the stomach could be a stigma of chronic liver disease, and would also indicate the presence of high portal pressure.