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정희정(Hee Jeong Jeong)이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),김지훈(Ji-Hoon Kim),정영인(Young-In Chung) 대한신경정신의학회 2018 신경정신의학 Vol.57 No.3
Objectives This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and those without psychosis (AD-P). Methods Overall, 31 AD+P patients and 29 AD-P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. AD-P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD-P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. Results The hippocampal volume in AD+P was smaller than that in AD-P. Conclusion These findings suggest that AD+P is associated with a reduced hippocampal volume.
이정진(Jeong Jin Lee),문은수(Eunsoo Moon),박제민(Je Min Park),이병대(Byung Dae Lee),이영민(Young Min Lee),정희정(Hee Jeong Jeong),최윤미(Yoonmi Choi),정영인(Young In Chung) 대한생물치료정신의학회 2014 생물치료정신의학 Vol.20 No.1
Objectives:It is important to examine factors affecting problem drinking to prevent social drinking from proceeding alcohol addiction. As the factors associated with problematic drinking are various according to age and gender, we aimed to investigate whether several clinical factors are associated with drinking behavior according to age and gender in general population. Methods:291 participants without experience of psychiatric diagnosis and treatment were recruited. Problematic drinking behavior was evaluated by Alcohol Use Disorder Identification Test(AUDIT). Depression, bipolarity, anxiety and impulsivity were measured using Beck Depression Inventory(BDI), Bipolar Spectrum Diagnostic Scale(BSDS), State-Trait Anxiety Inventory(STAI) and Barratt impulsiveness scale(BIS), respectively. The authors analyzed the effects of clinical factors on drinking behavior according to age and gender using univariate linear regression. Results:In younger group, there was no correlation between clinical variables and problematic drinking behavior. In middle aged group, however, BSDS total scores were significantly correlated with AUDIT scores(p=.006). Problematic drinking behaviors in middle-aged men were significantly associated with STAI-state(p=.027), total score and mania subscore of BSDS(p=.006 ; p=.001) and BIS(p=.011), but those in middle-aged women were associated with BDI (p=.022), STAI-state and trait(p=.027 ; p=.010), total score and mania subscore of BSDS(p=.031 ; p=.037), as well as depression subscore of BSDS(p=.012). Conclusion:These results suggest that factors associated with problematic drinking are different according to age and gender. Therefore, consideration on difference of gender and age effect on problematic drinking behavior is important to establish strategies for decreasing problematic drinking.
정희정(Hee Jeong Jeong),이영민(Young Min Lee) 대한노인정신의학회 2013 노인정신의학 Vol.17 No.2
Secondary mania is closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, play a major role in the affective, motor and cognitive symptoms of secondary mania. In this paper, we present the three main frontal-subcortical circuits : the dorsolateral prefrontal circuit, which mediates executive functions (i.e., the organization of information to facilitate a response) ; the anterior cingulate circuit, which is involved in motivated behavior ; the orbitofrontal circuit, which has medial (i.e., integration of visceral-amygdalar functions with the internal state of the organism) and lateral divisions (i.e., integration of limbic and emotional information into contextually appropriate behavioral responses). Impaired executive functions, apathy, disinhibition and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. The various neuropsychiatric manifestations of secondary mania may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.
알츠하이머병에서 초조/공격성과 신경해부학적 영역의 연관성
정민수(Min Soo Jung),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),정희정(Hee Jeong Jeong) 대한노인정신의학회 2013 노인정신의학 Vol.17 No.2
Objectives:The aim of this study is to identify the association between agitation/aggression and atrophy in specific brain areas in Alzheimer’s disease (AD). Methods:Fifty six patients with mild or moderate AD participated in this study. Cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE), and Clinical Dementia Rating (CDR). Agitation/aggression symptoms were measured using the Korean version of the Neuropsychiatric Inventory (K-NPI). Atrophies of brain were analyzed using Voxel Based Morphometry (VBM). Results:Higher scores of agitation/aggression were correlated with the atrophy of left middle temporal, left fusiform, right middle temporal, left inferior temporal, right inferior temporal, left superior temporal, left middle occipital, right orbitofrontal, right superior frontal, left angular and right middle frontal gyrus (p<0.001, uncorrected for multiple comparisons, extent threshold=200 voxel). Conclusion:Agitation/aggression was correlated with specific neuroanatomical changes in mild or moderate AD.
기분장애 환자에서 성별에 따른 일주기유형과 문제음주행동과의 관련성
공자영(Ja Young Kong),강태욱(Tae Uk Kang),문은수(Eunsoo Moon),박제민(Je-Min Park),이병대(Byung-Dae Lee),이영민(Young-Min Lee),정희정(Hee-Jeong Jeong) 대한생물치료정신의학회 2018 생물치료정신의학 Vol.24 No.3
Objectives:Some studies have reported that chronotypes, among several factors, could contribute to problematic drinking. However, there is little evidence confirming this relationship between chronotype and problematic drinking based on gender differences in mood disorder. This study is to investigate the difference of the relationship between chronotype and problematic drinking according to gender differences in mood disorder. Methods:Two hundred fifteen patients with mood disorder were recruited. Problematic drinking and chronotypes were assessed by the Alcohol Use Disorder Identification Test in Korea(AUDIT) and the Korean translation of composite scale of morningness(KtCS). We analyzed the correlation between KtCS and AUDIT using Pearson’s correlation, and compared AUDIT scores according to chronotypes classified by KtCS between male and female patients using analysis of variance(ANOVA). Results:There was no significant difference in AUDIT scores between the male and female patients(t=0.91, p=0.183). In female patients, eveningness had significantly higher AUDIT scores than other chronotypes(F=0.199, p=0.033). Meanwhile, in male patients, there was no significant difference in AUDIT score among chronotypes(F=0.008, p=0.933). Conclusion:This study suggests that eveningness might be associated with problematic drinking in female patients who suffer from mood disorder. It also suggests that chronotherapeutical treatment might be able to help improve the course in female patients with mood disorder. In the future, a large-scale prospective study is needed to confirm these results.
뇌혈관질환이 없는 노년기 우울증 환자에서 피질 두께의 감소
이강윤(Kang Yoon Lee),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),정희정(Hee Jeong Jeong),정영인(Young-In Chung),김지훈(Ji-Hoon Kim) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). Methods:Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal compari-son subjects : n=26) underwent 3-tesla MRI. Results:Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. Conclusion:Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.
한국인 조현병 집단에서 에스트로겐 대사(ESR1, COMT) 유전자의 가족연합분석: 예비연구
이연수(Soo Yeon Lee),이병대(Byung Dae Lee),박제민(Je Min Park),이영민(Young Min Lee),문은수(Eunsoo Moon),정희정(Hee Jeong Jeong),정우영(Woo Young Jung),서화규(Hwagyu Suh),김경원(Kyungwon Kim) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.3
Objectives:A recent study of a European sample implied that the 14 genes previously known to be related with schizophrenia may play little roles. But much work remains before dismissing these genes from their connection to schizophrenia. This is a pilot study for family based association test (FBAT) analysis of estrogen metabolism gene in a Korean population with schizophrenia. Methods:27 probands with schizophrenia were recruited with their parents and siblings. The subjects were interviewed using Korean versions of diagnostic interview for genetic studies and family interview for genetic studies. We analyzed 2 single nucleotide polymorphism (SNP) of ESR1, COMT gene. We performed FBAT and linkage disequilibrium analyses for each individual SNP. Results:We found a significant SNP of ESR1 gene in chromosome 6 for the qualitative phenotype of schizophrenia. That result was replicated for the quantitative phenotype of apparent onset, apparent onset of psychosis, and first treatment age. We also found a significant SNP of ESR1 gene in chromosome 6 for the quantitative phenotype of any delusions. Conclusions:Our results show that quantitative traits such as age of onset, any delusions, and any hallucinations could be continuous with qualitative trait in schizophrenia. But we should be very cautious because there are clear limitations in some nominal number of SNPs and the small incomplete pedigrees. In the future, FBAT analyses in families with subtyped schizophrenic probands according to personality, working memory, cognition will facilitate fine mapping analyses for searching candidate genes of schizophrenia.
손제현(Je Hyun Sohn),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),김지훈(Ji-Hoon Kim),정영인(Young-In Chung) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2
Objective:The purpose of this study is to investigate the difference on regional volume in temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and Alzheimer’s disease patients without psychosis (AD-P). Methods:Altogether, 24 AD+P and 25 AD-P matched age, gender, and clinical dementia rating sum of box (CDR-SOB) were include from a Memory impairment clinics of Pusan National University Hospital in Korea. AD+P were diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. Grey matter volume of temporal lobe was measured with 3-tesla magnetic resonance imaging and freesufer analysis. Analysis of variance was used to investigate the association between temporal lobe and AD+P after controlling age, gender, education years, CDR-SOB and total intracranial volume. Results:We found an association between AD+P and reduced grey matter volume in total temporal lobe as well as in specific temporal regions such as left middle temporal lobe, left inferior temporal lobe, both hippocampus and both fusiform. Conclusion:Our findings suggest that AD+P are associated with reduced grey matter volume of temporal lobe.
태아기 성호르몬이 여성의 알츠하이머병의 발병에 미치는 영향 : 2D/4D 손가락 길이 비율을 이용한 단면 연구
강태욱(Tae Uk Kang),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eunsoo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),서화규(Hwagyu Suh),정영인(Young-In Chung) 대한노인정신의학회 2020 노인정신의학 Vol.24 No.2
Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.