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정희원,고영초,한대희,심보성,지제근 대한신경외과학회 1979 Journal of Korean neurosurgical society Vol.8 No.1
Two case of cerebral infestation with Paragonimus westermani complicating obstructive hydrocephalus are presented. The diagnosis was aided by brain CT scan and Conray ventriculogam. Both cases showed a strong positive intradermal test with relevant histories of eating crayfishes in roast form. In simple skull X-ray, one stowed characteristic shell-like calcifications over the temporo-occipital region and the otter showed multiple round calcifications over the suboccipital region. Brain CT scan demonstrated much more characteristic calcifications with marked ventricular dilatation. Conray ventriculogram disclosed obstructive hydrocephalus in both cases, one at the level of the cerebral aqueduct and the other at the level of the fourth ventricle outlet. Both patients were subjected to ventriculoatrial shunts and concommitant Bithionol therapy with marked improvement. The case involving the cerebellum and the fourth ventricle outlet was submitted to the posterior fossa exploration to be verified as a rare cerebellar paragonimiasis.
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베토벤의 후기 피아노 소나타에서 나타나는 변주 기법 연구
정희원 서울대학교 서양음악연구소 2018 음악이론연구 Vol.30 No.-
Whereas a theme-and-variations movement had been considered a less important movement in a multi-movement piece, Beethoven grants a new status to this form by concluding a large-scale work with a slow variation movement. This study focuses on the last movements of Piano Sonatas Op. 109 and Op. 111. These variation sets show that Beethoven relied on primary elements of tonal relationships for musical materials and creates large-scale movement from those basic ideas. Also remarkable is the way he unfolds variations with those materials. The variation form is transformed into a large-scale organic structure with a new level of complexity, as Beethoven integrates variations with the individual formal designs. Beethoven makes listeners participate in a dramatic procedure of the variation-set by adding the feeling of release that comes with the return of the theme. These features in the variations sets remind us of the important concept of Beethoven’s late style, continuity and synthesis. 본 연구는 베토벤의 후기 피아노 소나타 중 작품번호 109와 111의 마지막 악장에서 주제와 변주 형식이 사용된 것에 주목하여, 이 곡들에서 구체적으로 어떻게 변주 기법이 사용되었는지 고찰한다. 두 변주곡 악장에서 주목할 점은 음악 재료에 있어서 조성 언어의 매우 기본적인 요소를 택해 변주곡 전체를 발전시킨다는 점이다. 즉, 변주가 진행됨에 따라 텍스처는 달라지더라도 주제의 아이디어는 단순하고 기본적인 형태로 제시된다. 또한 이 두 변주곡의 형식적인 측면을 보면 극적인 구성이 결합되어 마지막 주제가 원래의 형태로 돌아올 때 긴장의 해결감을 준다. 이는 각각의 변주가 서로 연결될 뿐 아니라 변주곡 악장 전체가 하나의 유기적이고 극적인 구조로 짜여 있다는 것을 보여준다.
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시신경 손상없이 좌측 시신경공을 통과한 이물(알미늄제 젓가락)의 1예
정희원,차희중,한대희,심보성 대한신경외과학회 1976 Journal of Korean neurosurgical society Vol.5 No.2
A 20-year-old, male patient was admitted to the Department of Neurosurgery, Seoul National University Hospital, complaining- of painful swelling of the left orbit. Two days before admission, patient sustained piercing of an aluminium chopstick at his left upper eyelid by his friend accidentally. Fluttered friend tried to pull out the chopstick manually but only broke its proximal portion. On neurologic and ophthalmologic exam, he was fully conscious and free from neurologic deficits at all. His visual acuity was as usual and examination of fundi, extraocular muscle functions, visual field and pupillary light reflex were all within normal limit. Subconjuctival hemorrhage and chemosis were positive findings. Skull X-rays including optic foramen, view revealed broken distal part of the chopstick, about 7 ㎝ in length, which passed through the left lateral orbit and left optic foramen to reach sellar region across the midline. Emergency Kro¨nlein-Berke's lateral orbitotomy was performed and the chopstick was removed without difficulty. Postoperatively patient showed good recovery and presented quite normal and usual eve function.
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정희원,한종우,김종수,정천기,전상룡,최길수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12
The present study investigated whether organotypic spheroids derived from human fetal brain tissue, cultured at agarose-overlay media may serve as an optimal in vitro model for multidisciplinary studies in human neurobiology, particularly in the fields of tumor invasiveness and its biochemical mechanism, using light microscopy. electron microscopy and immunohistochemical staining Eight fetal brain tissues of 8-9 weeks of gestation were minced and explanted into agarose-coated culture wells. After three to five days these human fetal brain tissue fragments emerged as spheroids and could be maintained as organotypic spheroids for up to seven weeks. Light and electron microscopic studies of spheroids demonstrated that most cells were poorly differentiated and there were no definite mature neurons or glial cells after enough culture time, but some cells showed certain evidence suggestive of differentiation to neurons or glial cells immunohistochemical staining for glial fibrillary acidic protein(GFAP) and neuron specific enolase(NSE) demonstrated that NSE-positive cells were oval or spherical cells containing abundant cytoplasm and GFAP-positive cells were fibrillary cytoplasma-containing cells which showed some evidence suggestive of differentiation to glial cells by light microscopy. In future, adding some modifications in culture, this organotypic spheroids derived from the human fetal brain may serve as an optimal in vitro model for neurobiology, especially in the field of studies on tumor invasiveness through co-culture with microtumor spheroids.
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초점성 뇌허혈에서 재관류가 국소뇌혈류 변화에 미치는 영향에 관한 실험적 연구
정희원,고학종,김현집,조병규,김성완,민병구,한대희,심보성,최길수 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.3
Reperfusion into focal ischemia using a transorbital snare ligature was studied in 20 unanesthetized cats following middle cerebral arrtery (MCA) occlusion of 1 to 6 hours duration. Changes of a regional cerebral blood flow (rCBF) were investigated upon with a hydrogen clearance method in the center and periphery of the MCA territory, which were correlated with the size of infarct delineated by a 2% triphenyl tetrazolium chloride solution and with the occurrence of severe brain edema or hemorrhagic infarct. The results were as followings: 1) Post-ischemic hyperperfusion was usually found after 1 hour occlusion of MCA followed by 2 hours recirculation. Final rCBF, however, reached pre-occlusion value and little or no infarct was found. 2) In the 2 hours occlusion-reperfusion group, hypoperfusion after reopening of MCA was regularly found in both the center and the periphery of ischemia, which was well contrasted with hyperperfusion in the I hour occlusion group and was accompanied by evident but mild infarcts. 3) After 4 and 6 hours occlusion, there was usually evident post-ischemic hyperperfusion soon followed by development of severe hypoperfusion and a higher grade of infarct and hemispheric swelling was found. 4) Final hypoperfusion after transient MCA occlusion was observed only after ischemic periods lasting 2 hours or more irrespective of preceding post-ischemic hyperperfusion and was only related to the duration of the occlusion and not to the degree of blood flow disturbance. 5) Spontaneous hyperemia during occlusion was found in 3 of the 5 cats used in each of the 4 and 6 hours occlusion groups, in which there was marked hyperperfusion after reopening of MCA followed by severe hypoperfusion and transtentorial herniation associated with resulting extensive hemorrhagic infarct and marked hemispheric swelling. 6) Hemorrhagic infarcts were found in one cat of the 4 hour-occlusing group and two of the 6 hour-occlusion group, all of whom showed early hyperemia before reperfusion predictable of such a detrimental result. 7) These data indicate that potential hazard for surgical revascularization in the acute stage of ischemic stroke should be considered in case profound ischemia had already progressed for 4 hours or more and especially when hyperemia during the initial stage of severe ischemia is observed at the center and the periphery of the ischemic area expected.
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