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치주조직 재생용 플루르비프로펜 함유 키토산 비드의 제조 및 용출특성
이수진,박윤정,이승진,정종평 ( Su Jin Rhee,Yoon Jeong Park,Seung Jin Lee,Chong Pyoung Chung ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A With the aim of improving periodontal regeneration efficacy, as a biodegradable local drug delivery device, drug releasing chitosan beads were prepared. Chitosan beads were prepared through the formation of intermolecular or intramolecular ionic interaction between chitosan and sodium tripolyphosphate and were loaded with flurbiprofen. The mean diameter of the beads was 250 ㎛. Drug loading efficiency was improved by regulating the pH of tripolyphosphate solution. The drug release kinetics mainly depended upon the hydrophobic properties of the flurbiprofen, that is, the release of flurbiprofen showed initial burst with rapid release for the first day followed by a levelling off of the release rate. However, the release rate could be controlled by the formulation factor including the pH, concentration of the tripolyphosphate solution, gelation time, drug contents. From these results, flurbiprofen loaded chitosan beads were anticipated as biodegradable local drug delivery devices for periodontal regeneration.
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치주조직 재생용 플루르비프로펜 함유 키토산 비드의 제조 및 용출특성
이수진,박윤정,이승진,정종평 梨花女子大學校 藥學硏究所 1998 藥學硏究論文集 Vol.- No.7
With the aim of improving periodontal regeneration efficacy. as a biodegradable local drug delivery device. drug releasing chitosan beads were prepared. Chitosan beads were prepared through the formation of intermolecular or intramolecular ionic interaction between chitosan and sodium tripolyphosphate and were loaded with flurbiprofen. The mean diameter of the beads was 250 ㎛. Drug loading efficiency was improved by regulating the pH of tripolyphosphate solution. The drug release kinetics mainly depended upon the hydrophobic properties of the flurbiprofen. that is, the release of flurbiprofen showed initial burst with rapid release for the first day followed by a levelling off of the release rate. However, the release rate could be controlled by the formulation factor including the pH. concentration of the tripolyphosphate solution. gelation time, drug contents. From these results. flurbiprofen loaded chitosan beads were anticipated as biodegradable local drug delivery devices for periodontal regeneneration.
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