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Tamoxifen과 celecoxib가 시험관내 SK-OV-3 난소암세포주에 미치는 영향
안윤걸 ( Yun Gul Ahn ),김성수 ( Sung Soo Kim ),전완주 ( Wan Joo Chun ),정일영 ( Il Young Cheong ),송영준 ( Young Jun Song ),소은정 ( Eun Jung Soh ),황종윤 ( Jong Yun Hwang ),조준식 ( Jun Sik Cho ),이동헌 ( Dong Heon Lee ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.8
토끼의 격리된 폐 모델에서 저산소성 폐혈관 수축시 비선택성 양이온 통로 차단제 Gadolinium 의 역할
안원식,김종성,김성덕,김희수,정일영,오아영 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.2
The Effects of NOnspecific Cation Blocker Gadolinium on Hypoxic Pulmonary Vasoconstriction in the Isolated Rabbit Lung Seong Deok Kim, M>D., Chong Sung Kim, M.D., Hee Soo Kim, M.D., Won Sik Ahn, M.D. Ah Young Oh, M.D., and Il Young Cheong, M.D.?? Department of Anesthesiology, Colege of Medicine, Seoul National University and ??Kangwon University, Korea Background: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation. Recent hypotheses have emerged indicating that O_2 levels per se can regulate ion channel activity. The modulation of both cation channels differs according to the conduit or resistance pulmonary vessel type. However, it is not yet studied that the cation channel blocker has the same effect in an animal experimental model, which can exclude several factors that may influence on HPV. The purpose of the present study was, therefore, to determine the effect of nonspecific cation blocker, Gadolinium, on HPV in a rabbit model of isolated lung perfusion. Methods: In adult white rabbits (n = 6), lungs were isolated and perfused with the constant pulmonary perfusate flow. Acid-base status and electrolytes of perfusate also constantly maintained. Thirty minutes after, baseline hypoxic pulmonary vasoconstriction (HPV) was measured as the difference of pulmonary artery pressure between a period of 21% normoxic gas inhalation and that of 3% hypoxic gas inhalation. After another thirty minutes, Gadolinium 50 ㎍ were mixed to the perfusate, and then HPV were measured three times. After then Gadolinium 100, 200, 400 ㎍ were mixed to the perfusate and HPV were measured. Results: Gadolinium decreased the HPV response according to the dose. The ED_50 of the response was 143 ㎍/100 ml. Conclusions: The regulation of HPV is based on the cation channel in the isolated rabbit lung. (Korean J Anesthesiol 2001; 41: 222~228)
개에서 sevoflurane 마취중에 diltiazem 투여가 폐내 션트에 미치는 영향
김종성,정일영 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.4
The effects of sevoflurane and subsequent administration of diltiazem on intrapulmonary shunt and oxygenation were studied in pentobarbital anesthetized dogs. After inhalation of 1MAC of sevoflurane and subsequent intravenous administration of clinical dose of diltiazem (loading dose 0.2 mg/kg, maintenance dose 0.01 mg/kg/min), there were no changes in cardiac output, arterial oxygen tension, mixed venous oxygen tension, oxygen transport, oxygen consumption, intrapul-monary shunt ratio, pulmonary vascular resistance, alveolar-arterial oxygen difference. After intravenous administration of diltiazem with bolus (0.4 mg/kg) and maintenance dose (0.02 mg/ kg/min), pulmonary vascular resistance was significantly decreased (p$lt;0.05) but the other parameters indicating pulmonaruy hemodynamics and oxygenation were unchanged. These results suggest that concomittent use of the two classes of drugs is not induce significant changes in pulmonary hemodynamic and oxygenation, and can be used safely in patient with normal cardiopulmonary function when clinical concentration of both were used.
가토의 유리폐에서 체온의 변화가 저산소성 폐혈관 수축에 미치는 영향
함병문,정일영 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.6
Background : We studied the effects of body temperature changes and repeated hypoxic stimulation on hypoxic pulmonary vasoconstriction (HPV). Methods : We isolated lungs from 15 rabbits and perfused them at a constant flow of 30 ml/kg/min with a 3% albumin-physiologic salt solution containing autologous blood. After a 30-minute stabilization, the temperature of the perfusate was changed from 38oC to 32oC gradually. The lungs were ventilated for 15 minutes with a hyperoxic gas mixture consisting of 95% oxygen and 5% carbon dioxide and then for 5 minutes with a hypoxic gas mixture consisting of 3% oxygen and 5% carbon dioxide with the balance being nitrogen. We repeated the hypoxic stimulation 3 times at the same temperature. The mean pulmonary artery pressure changes and ventilation-related parameters were measured at each hypoxic stimulation. Results : With the first hypoxic stimulation, the hypoxic pressure response at the end of the 5-minute hypoxic period decreased significantly at 32oC. With the second and the third hypoxic stimulations, the hypoxic pressure responses at the end of the 5-minute hypoxic period decreased significantly at both 34oC and 36oC. With repeated hypoxic stimulations, the hypoxic pressure responses potentiated significantly at all temperatures. The baseline mean pulmonary artery pressure increased significantly below 34oC. Conclusions : The HPV decreased with the reduction in body temperature and was potentiated by repeated intermittent hypoxia; also, the pulmonary vascular resistance increased with the reduction in the body temperature. (Korean J Anesthesiol 1999; 37: 1117∼1124)
수술후 노인 환자에서의 자가 통증 조절시 진통 효과와 수술후 인식 장애
김명원,정일영,이지희,장호조 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.36 No.6
Background : Since postoperative cognitive impairement is common in elderly patients and normal cognitive function is important for proper use of patient controlled analgesia (PCA), we compared the efficacy, adverse effect and postoperative cognitive impairment among postoperative elderly patients given the PCA morphine, fentanyl and meperidine. Methods : Forty-five elderly patients were randomly allocated to receive patient-controlled analgesia with either morphine, fentanyl or meperidine following upper abdominal surgery. Patients were evaluated for used doses, adverse effects, visual analogue scale, the satisfaction for analgesia during postoperative 2 days and the Mini Mental Status Examination (MMSE) and the Short Portable Mental Status Questionnaire (SPMSQ) at posoperative 1 day. Results : Patients receiving the PCA fentanyl used more opioid based on a dose expressed as morphine equivalents using the putative potency ratios of 1:10:0.01 (morphine/meperidine/fentanyl). But adverse effects, visual analoe scale, and the satisfaction for analgesia were not statistically different between groups. The decrease in MMSE in the PCA-meperidine group was significantly greater than that seen in the PCA-fentanyl group and the PCA-morphine group. SPMSQ were not statistically different between groups. Conclusions : The present result suggest that PCA is effective method in posterative elderly without serious complications. But PCA meperidine may be avoided in the elderly because it can contribute to decrease postoperative cognitive function. (Korean J Anesthesiol 1999; 36: 1017∼1025)