Study on the Effect of Air Circulator on Temperature Distribution in an Oyster Mushroom Farm

정원근,임학규,김태한 한국농업기계학회 2013 바이오시스템공학 Vol.38 No.2

Purpose: Recently, domestic and abroad consumption of mushroom has been increasing. Especially, oyster mushroom has been the most consumed product, sharing one third of the mushroom market. The air temperature differences between relative positions of the mushroom farms were needs to be minimal. However, in reality, the air temperature differences ranged from 2 to 5℃. Because of this, the mushrooms are non-uniform growth as well as decrease in both quality and quantity. Although air circulators have been employed by oyster mushroom farms to minimize air temperature differences,no experiments have been performed to illustrate the effect of the air circulators. Methods: This experiment is designed to analyze the effect of the air circulation by constructing a prototype air circulator and measuring the air temperature when the circulator was position at different heights (50 cm, 150 cm, 200 cm) from the floor in the center. Result: The horizontal plane air temperature of the first growing bed when the air circulator was installed 50cm above the floor in the center, once not using the air circulators and the other time using the air circulators, yielded the air temperature differences of 8.6℃ and 1.8℃ and deviations of 2.82 and 0.60, respectively. The third growing bed's air temperature differences were 10.0℃, 1.6℃and deviations 3.28, 0.64, each respectively. These outcomes proved that the use of air circulators minimized the air temperature difference and deviation. The use of air circulators helped minimize the air temperature differences and the derivations in oyster mushroom farm. Conclusion: The use of air circulators helped balance the air temperature distribution in oyster mushroom farm.

젓가락에도 상처가 핀다

정원근 천년의시작 2004 (계간)시작 Vol.3 No.3

Value of imaging study in predicting pelvic lymph node metastases of uterine cervical cancer

정원근,박경란,이경자,김규보,이지혜,정송미,김이준,김지영,윤혜전,강병철,구혜수,성순희,조민선,박상희 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.4

Purpose: To evaluate the diagnostic accuracy of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) in predicting pelvic lymph node (LN) metastases in patients with cervical cancer. Materials and Methods: From January 2009 to March 2015, 114 patients with FIGO stage IA1-IIB uterine cervical cancer who underwent hysterectomy with pelvic lymphadenectomy and took CT, MRI, and PET/CT before surgery were enrolled in this study. The criteria for LN metastases were a LN diameter ≥1.0 cm and/or the presence of central necrosis on CT, a LN diameter ≥1.0 cm on MRI, and a focally increased FDG uptake on PET/CT. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for pelvic LN metastases were estimated. Results: The sensitivity, specificity, PPV, NPV, and accuracy for detection of pelvic LN metastases were 51.4%, 85.9%, 41.3%, 90.1%, and 80.3% for CT; 24.3%, 96.3%, 56.3%, 86.8%, and 84.6% for MRI; and 48.6%, 89.5%, 47.4%, 90.0%, and 82.9% for PET/ CT, respectively. The sensitivity of PET/CT and CT was higher than that of MRI (p=0.004 and p= 0.013, respectively). The specificity of MRI was higher than those of PET/CT and CT (p=0.002 and p=0.001, respectively). The difference of specificity between PET/CT and CT was not statistically significant (p=0.167). Conclusion: These results indicate that preoperative CT, MRI, and PET/CT showed low to moderate sensitivity and PPV, and moderate to high specificity, NPV, and accuracy. More efforts are necessary to improve sensitivity of imaging modalities in order to predict pelvic LN metastases.

Displacement of Surgical Clips in Patients with Human Acellular Dermal Matrix in the Excision Cavity during Whole Breast Irradiation Following Breast-Conserving Surgery

정원근,김규보,백남선 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose The purpose of this study was to investigate the displacement of surgical clips in the excision cavity during whole breast irradiation following breast-conserving surgery (BCS) with or without acellular dermal matrix (ADM) insertion, and to analyze clinicopathologic factors associated with the displacement of surgical clips. Materials and Methods From 2016 to 2017, 100 consecutive breast cancer patients who underwent BCS with the placement of surgical clips (superior, inferior, medial, lateral, and deep sides) in the tumor bed were included in this study. All patients took first planning computed tomography (CT) scan (CT 1) before whole breast irradiation and second CT scan (CT 2) before boost irradiation. Between two sets of planning CT, the displacement of surgical clips was calculated from the !X (lateral–medial), !Y (anterior–posterior), !Z (superior–inferior), and threedimensional (3D) directions. Patients were divided into two groups according to the breast volume replacement with ADM: group A with ADM and group B without ADM. Results The means and 1 standard deviations of 3D displacement for superior, inferior, medial, lateral and deep clips were 5.2±2.9, 5.2±3.2, 5.6±4.5, 5.6±4.3, and 4.9±4.9 mm in entire cohort (n=100); 5.6±2.6, 6.0±3.5, 6.7±5.8, 6.7±5.7, and 6.1±7.4 mm in group A (n=38); 4.9±3.1, 4.8±3.0, 5.0±3.5, 5.0±2.9, and 4.3±2.8 mm in group B (n=62), respectively. The 3D displacements of group A were longer than those of group B, but only significant difference was observed in lateral clip (p=0.047). Conclusion This study demonstrated displacement of surgical clips during whole breast irradiation in patients with ADM insertion. For patients who had breast volume replacement using ADM, adaptive boost planning should be considered.

수종 한국산 식물성분의 항종양시험에 관한 연구

정원근 대한약학회 1973 약학회지 Vol.17 No.4

Four main components of plants produced in Korea were subjected to the screening test of antineoplastic activity against Ehrlich ascites carcinoma, SN 36 leukemia and sarcoma 180. Of the four components, bilobol showed comparatively active survival effect.

數種韓國産 植物成分의 抗腫瘍 試驗에 관한 硏究

정원근 國立保健硏究院 1973 국립보건연구원보 Vol.10 No.-

s-Triazine의 Ring Transfromation에 의한 Pyrimidopyrimidine의 합성

정원근,김상기,천문우,김득준 대한약학회 1984 약학회지 Vol.28 No.2

We have investigated the feasibility of using cyclic ambident nucleophiles in s-triazine ring transformation reaction and found that they can replace the $N_{1}-C_{2-N_{3}$ fragment of s-triazine directly in basic conditions, yielding the corresponding bicyclic products. In this paper, we described the reaction and mechanistic aspects of s-triazine to pyrimidopyrimidine transformation by 6-aminouracil derivatives. This type of ring transformation is supposed to be first attempt that deals with the successful s-triazine to bicyclic heterocycle transformation.

s-Triazine의 Ring Transformation에 의한 5-FU의 합성

정원근,정진현 대한약학회 1982 약학회지 Vol.26 No.1

We had reported that s-triazine can readily be converted into the corresponding 5-substituted pyrimide. In order to develop new synthetic method of 5-fluorouracil, we tried to replace eliminating fragment, 1, 3-dimethylurea, by fluoroacetamide, which was expected to undergo nucleophilic attack by proton extraction of both .alpha.-hydrogen and aminohydrogen by lithium diisopropylamide (LDA). We found that 5-fluorouracil could be transformed from s-triazine under strong base condition like LDA as well as other 5-substituted pyrimidines.

Analysis of Air Circulation in Oyster Mushroom Farm

정원근,김태한,임학규 한국농업기계학회 2012 바이오시스템공학 Vol.37 No.2

Purpose: Oyster mushroom farm which could not meet optimum temperature range yields non-uniform sized, low quality products. Thus, this study, utilizing STAR CCM+, one of the computational fluid dynamics (CFD) programs, analyzed the impact of air circulation and temperature distribution. Methods: After we visited numerous mushroom farms, we measured the temperature at the discharge ports of heaters, fan capacity, and the locations of the air circulators in the farms. According to the data, most mushroom growers installed the heaters near the entrance and discharge ports of the heaters at the third growing bed on the same height as the heaters in the entrance. The temperature at the discharge port of heater was 26°C, and the fan capacity was 4,500 m3/hr. The air circulator was placed in the center of the mushroom farm 50cm above the ground, and its capacity of inlet port was 1,100 m3/hr and discharge port 1,600 m3/hr. The mushroom farm was insulated. Results: According to the analysis of the temperature distribution in the vertical plane of the entrance side, no air circulation causes the high temperature zone of 296~299K at the discharge port of the heater to take up 34% of area while the operation of air circulators causes it to occupy only 9%. This means that not using air circulators leads to a concentration of high temperature at the discharge port near the entrance. In addition, with the results of the analysis of the temperature distribution in the vertical planes of the center, no air circulation causes the temperature zone of 295~298K at the discharge port of the heater to take up 48% of area while the operation of air circulators causes it to occupy 80%. This shows that the high outlet port temperature disseminated to the center. Conclusions: After ninety minute operation of both heater and air circulator, the interior temperature became stabilized in the mushroom farm. Air circulation made the high temperature at the discharge port disseminate to the center and exit in the farm and equalize the temperature distribution.

에르릿히 복수암에 있어서 $C^{14}$-초산염 대사

정원근,이상돈,Chun, Won-Kun,Rhee, Sang-Don 대한생리학회 1970 대한생리학회지 Vol.4 No.2

Tissue homogenates of Ehrlich ascites tumor tissues and several normal tissue of mice were incubated separately in medium maintaining $C^{14}$_acetate concentrations of 5, 10, 20, 30, 40, 50 and 60 mg%, in order to determine maximum oxidative rates of acetate. In every incubation experiments, respiratory $CO_2$ samples rapped by alkaline which was placed in the center well of the incubation blask were analyzed for total $CO_2$ Production rates and their radoactivies. The fractions of $CO_2$ from medium acetate to total $CO_2$ production rate were obtained with relative specific activities (RSA) which were calculated by ratio between specific activities (SA) of $CO_2$ and medium $CO^{14}$_acetate and $CO_2$ production rates from medium acetate were calculated from RSA and total $CO_2$ production rates. Maximum plateau values of oxidative rates described above were determined at incubation experiments of various concentrations of medium acetate and compared the oxidative rates of acetate of tumor with those of normal tissues such as kidney, brain and liver. Maximum plateau values of total $CO_{2}$ Production rates were obtained at acetate concentration of 20 mg% and represent $25.0{\pm}0.54\;{\mu}M/hr/gm$ in the brain, $16.3{\pm}2.5$ in the kidney, $9.1{\pm}1.78$ in the liver and $11.5{\pm}3.2\;{\mu}M/hr/gm$ in the ascites tuners. Substancial $CO_2$ yield was observed in the tumor tissues as in the normal tissues. On the other hand, plateau values of RSA were $25.7{\pm}1.04%$ in thee brain, $9.1{\pm}0.72%$ in the kidney, $2.5{\pm}0.73%$ in the liver and $0.51{\pm}0.12%$ in the tumor tissues. $CO_2$ yields from the medium acetate, were 4.19 in the kidney, 2.28 in the brain, 0.228 in the liter and $0.059\;{\mu}M/hr/gm$ in the tumor tissue. These show wide range even in the normal tissue but remarkable decrease in the tumor tissue. This fact means that further oxidation of acetate was inhibited remarkably in the tumor tissue.