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HT22 세포에서 Curcumin 유도체가 Heme Oxygenase-1 발현에 미치는 효과
정용관,이윤정,천현자,류일환,지연주,채권우,김영숙,손지우,강현규,이성희,안인파,정헌택,배현옥,Cheong, Yong-Kwan,Lee, Yun-Jung,Chun, Hyun-Ja,Ryu, Il-Hwan,Jee, Yeon-Ju,Chae, Gwon-U,Kim, Young-Sook,Shon, Ji-Ue,Kang, Hyun-Gyu,Lee, Sung-Hee,An, Re 대한약학회 2011 약학회지 Vol.55 No.4
Curcumin, of which a critical characteristic is the capacity of crossing the blood-brain barrier, has been reported to induce the expression of neuroprotective heme oxygenase (HO)-1. The aim of this study is to compare HO-1-inducing capacity and neuroprotective activity of curcumin, its demethoxy (demethoxycurcumin, DMC; bis-demethoxycurcumin, BDMC) and hydrogenated derivatives (tetrahydrocurcumin, THC) in mouse hippocampal HT22 cells. Curcumin attenuated glutamate-induced cell death through HO-1 expression. DMC lacking a methoxy group on one of the aromatic rings possessed slightly lower activity in HO-1 expression and neuroprotection than curcumin. Similarly, BDMC, which lacks two methoxy groups on both of the aromatic rings, showed less activity than curcumin. These findings suggest that the presence of methoxy groups on the aromatic ring is required to enhance neuroprotective HO-1 expression. The reduction of the diarylheptadienone chain of curcumin by hydrogen, as in THC, was accompanied by a complete loss of ability to induce HO-1 expression and neuroprotection, suggesting that the conjugated double bonds of the central seven-carbon chain of curcumin may be essential for its ability to induce neuroprotective HO-1 expression. Our findings may provide useful information for further development of neuroprotective HO-1 inducers.
임상연구 : 어깨 관절경 수술 후 Ropivacaine과 Fentanyl의 어깨 관절 내 지속 주입의 진통 효과
정용관 ( Yong Kwan Cheong ),손용 ( Yong Son ),송윤강 ( Yoon Kang Song ),김태요 ( Tai Yo Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.4
Background: Arthroscopic shoulder surgery can result in moderate to severe postoperative pain. This study compared the postoperative analgesic effects of an intra-articular patient-controlled analgesia (PCA) infusion of 0.25% ropivacaine used with or without fentanyl after arthroscopic shoulder surgery. Methods: Sixty patients undergoing arthroscopic shoulder surgery under general anesthesia were randomly assigned to three groups. After surgery, normal saline 21 ml (group 1; n = 20), and 0.25% ropivacaine 21 ml (group 2 and group 3; n = 20 respectively), was infused into the articular space through a PCA catheter, which was followed by an infusion of normal saline 99 ml (group 1), 0.25% ropivacaine 99 ml (group 2), or 0.25% ropivacaine 99 ml, including fentanyl 400μg (group 3) through the intra-articular PCA catheter at 2 ml/hr with a bolus dose of 0.5 ml with a lock out time of 15 minutes. The level of pain was assessed using a visual analogue scale (VAS) and a verbal pain score (VPS) 2, 4, 6, 8, 12, 24 and 36 hours after the intra-articular bolus injection. Results: The pain scores were significantly lower after 2, 4, 6 hours in group 2 and 3 than in group 1. However, after 8 hours, the pain scores were significantly lower in group 3 than in the other two groups. Conclusions: An intra-articular continuous infusion of 0.25% ropivacaine after arthroscopic shoulder surgery is more effective when used in conjunction with 400μg fentanyl. (Korean J Anesthesiol 2006; 50: 449~53)
증례보고 : Charcot-Marie-Tooth병 환자에서 발생한 Rocuronium에 의한 근이완에서의 회복 지연
정용관 ( Yong Kwan Cheong ),이철 ( Cheol Lee ),손용 ( Yong Son ),송윤강 ( Yoon Kang Song ),김태요 ( Tai Yo Kim ),김대중 ( Dea Jung Kim ),오세리 ( Se Ri O ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.1
Charcot-Marie-Tooth disease, which is also known as hereditary motor and sensory neuropathy, is a heterogenous group of inherited diseases of the peripheral nerve. The spectrum of severity varies from asymptomatic individuals to those with severe limb abnormalities requiring corrective surgery. We report two brothers who had previously been diagnosed with Charcot-Marie-Tooth disease 3 years earlier and were scheduled to undergo a correction osteotomy of both feet under general anesthesia. General anesthesia was induced with propofol 2 mg/kg, rocuronium 0.8 mg/kg and was maintained with O2-N2O-Sevoflurane. The younger brother showed no delay in recovery of the neuromuscular blockade but the elder brother showed a delay. (Korean J Anesthesiol 2007; 53: 145~9)
증례보고 : Sevoflurane 마취 후 발생한 급성 간기능 부전
손용 ( Yong Son ),정용관 ( Yong Kwan Cheong ),김대중 ( Dea Jung Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.3
We report a case of a suspected acute hepatic dysfunction after general anesthesia with sevoflurane. A 71 year old female underwent a laparoscopic appendectomy under O2-N2O-sevoflurane anesthesia. She had no history of anesthesia, allergy, hypertension, diabetes or hepatitis. Four hours after surgery, she developed a conscious disturbance and became comatose. There was a marked increase in the serum aspartate aminotransferase, alanine aminotransferase, activated partial thromboplastin time and prothrombin time level, but the platelet and eosinophil counts were within the normal range. Her hepatic dysfunction improved after conservative therapy. She recovered gradually and was discharged after 24 days of hospitalization. Sevoflurane is believed to be the possible cause of the acute hepatic dysfunction in this case. (Korean J Anesthesiol 2006; 51: 359~62)
임상연구 : 이비인후과수술을 받는 환자에서 수술 전 Dexamethasone 투여가 Profopol 정주통 및 수술 후 오심과 구토에 미치는 효과
이철 ( Cheol Lee ),김태요 ( Tai Yo Kim ),송윤강 ( Yoon Kang Song ),손용 ( Yong Son ),정용관 ( Yong Kwan Cheong ),김민수 ( Min Soo Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.5
Background: Induction with propofol has a high incidence of pain, as well as postoperative nausea and vomiting (PONV). The aim of this study was to assess the effect of a course of dexamethasone on the pain, postoperative nausea and vomiting associated with a Propofol injection, in patients undergoing otolaryngology-head and neck surgery. Methods: One hundred twenty adults, 20-60 years of age, ASA physical status I or II, were allocated to one of two groups. Either dexamethasone 5 ml (8 mg) or saline 5 ml was administered intravenously to each group. After 60 seconds, propofol was injected into the patients` hand veins over a 30 second period and the patient was asked questions regarding the injection pain after 10 seconds. Postoperative nausea, vomiting and post-tonsilectomy pain were recorded in the recovery room (1 h after surgery) and in the hospitalization area (6 h after surgery). Results: The severity and incidence of pain at the time of the propofol injection, PONV, and the level of post-tonsillectomy pain were significantly lower in the dexamethasone group than in the control group. Conclusions: The prophylactic intravenous administration of 8 mg dexamethasone is effective in reducing the severity of pain after a propofol injection and after the tonsillectomy, and decreased the incidence of PONV. (Korean J Anesthesiol 2006; 50: 490~4)
폐암의 척추 전이로 양측 하지통증이 발생한 환자에서의 척수자극술 -증례보고-
오세리 ( Se Ri O ),하수미 ( Soo Mi Ha ),정용관 ( Yong Kwan Cheong ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.3
Spinal metastasis is common in patients with cancer, as the spine is the third most common site for metastasis of lung cancer. A 58-year-old woman was suffering from pain in her both legs due to spinal metastasis of lung cancer. She was treated with various nerve blocks including lumbar epidural block, and continuous epidural block with morphine, subarachnoid alcohol block, and with opioid medication. None of these treatments were effective for the pain, but spinal cord stimulation produced excellent results. (Korean J Anesthesiol 2009; 56: 349∼52)
증례보고 : 전신마취 후 회복실에서 발생한 일과성 전기억상실증 -증례보고-
이철 ( Cheol Lee ),김태요 ( Tai Yo Kim ),송윤강 ( Yoon Kang Song ),손용 ( Yong Son ),정용관 ( Yong Kwan Cheong ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.1
Transient global amnesia is characterized by a sudden inability to form new memories (anterograde amnesia) that usually last for minutes to several hours but never longer than 24 hours. and there are no other focal neurologic signs or symptoms. Retrograde amnesia from a few hours to many years may also be associated with this condition. We report a case of a 56-year-old female patient who experienced transient global amnesia in the recovery room after general anesthesia. She repeated the same queries several times to persons nearby and appeared perplexed. A detailed neurologic examination was otherwise entirely normal. Her symptoms resolved completely the next day. (Korean J Anesthesiol 2006; 51: 130~2)
흰쥐 평활근세포에서 gliotoxin 세포독성에 대한 PKC의 효과
방현주(Hyun-Ju Bang),김진오(Jin-O Kim),오정택(Jung-Taek Oh),이한솔(Han-Sol Lee),정용관(Yong-Kwan Cheong),허정무(Jung-Mu Hur),오재민(Jay-Min Oh),최민규(Min-Kyu Choi),박승택(Seung-Taeck Park),정연태(Yeun-Tai Chung) 대한해부학회 2003 Anatomy & Cell Biology Vol.36 No.5
Gliotoxin은 Penicillium, Aspergillus, Gliocladium 및 Thermoascus와 같은 곰팡이들로부터 생성되며 여러 가지 곰팡이에 의한 질병이나 면역조절기능 같은 다양한 생리적 효과를 나타낸다. 최근에 다양한 세포주에서 gliotoxin에 의한 아폽토시스의 기전이 밝혀지고 있으며, Gliotoxin에 의한 아폽토시스 유도 시 칼슘의 농도가 증가하는 현상이 보고 되었다. 본 연구에서는 칼슘 및 칼슘과 상보적인 PKC를 전처리 한 세포에서 gliotoxin의 효과에 대하여 살펴보았다. Gliotoxin에 의한 세포의 손상에는 bcl-2 family인 bad의 발현이 증가하는 현상을 보였으며, 그와 반대로 bcl-2의 발현은 감소하였다. 또한 gliotoxin을 처리한 세포에서는 시간 의존적으로 caspase-3의 활성 증가와 DNA 분절현상이 관찰되었다. 칼슘과 PKC를 전 처리한 세포에서는 gliotoxin에 의한 세포의 손상을 억제하였으며, bcl-2의 발현이 대조군과 유사하였고 bad는 발현되지 않았다. 또한 caspase-3를 비활성화 시키고, DNA 분절을 억제시켰다. 이들 결과를 통하여 알 수 있는 것은, gliotoxin에 의한 세포의 죽음은 사립체에서 cytochrome c의 방출과 동시에 pro-apoptotic bcl-2 family의 발현을 통해서 caspase-3가 활성화되고, 그 결과 DNA 분절을 일으켜 아폽토시스를 유발시키는 것으로 추정된다. 칼슘 및 PKC를 전처리한 경우에는 사립체에서 bcl-2 family 부분에서 bad와 같은 pro-apoptotic bcl-2 family의 발현을 억제시킴으로써 그 후에 오는 caspase-3의 활성을 차단하는 것으로 사료된다. Aspergillus funigatus and other pathogenic fungi synthesize a toxic epidithi- odiopiperzine (ETP) metabolite, namely gliotoxin. Gliotoxin commonly react with sulfhydryl groups, and then, forms hydrogen peroxide. These fungal toxins induce apoptotic cell death in various cells. Apoptosis induced by gliotoxin need calcium. Effect of calcium preconditioning was not reported in gliotoxin-induced apoptosis. To examine the effect of protein kinase C (PKC) and calcium which was regulate caspase-3, PKC and calcium preconditioning before gliotoxin treatment, apoptotic agents such as bcl-2 family, caspase-3 and DNA fragmentation in A7r5 cell line from rat smooth muscle cell were studied. These results showed that gliotoxin induces the expression of bad of bcl-2 family, caspase-3 activation and DNA fragmentation in A7r5 cells. Gliotoxin treatment followed by calcium and PKC preconditioning suppress the Bad of bcl-2 family, and inhibited caspase-3 activation, respectively. These results suggest that PKC and calcium preconditioning protect the gliotoxin-induced apoptosis, through the protection of pro-apoptotic bcl-2 family in A7r5 cells.