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PMA로 자극되어진 세포에서 염증 Cytokine 발현에 미치는 Bovine Lactoferrin의 생물활성 영향
정승희,강호범,김재화,윤성식,남명수,Chung, Sung-Hee,Kang, Ho-Bum,Kim, Jae-Wha,Yoon, Sung-Sik,Nam, Myoung-Soo 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.3
유청단백질의 일종인 lactoferrin은 이미 많은 보고에 의해서 여러 가지 생리활성기능이 있는 것으로 밝혀지고 있는데, U937, NK92, 수지상세포의 분화된 상태인 mutz-3와 muDC를 이용하여 과민반응과 천식, 면역 관련 유전자의 발현에 미치는 영향을 조사 한 결과 의미 있는 결과를 도출하였다. Lactoferrin 단독 또는 면역증강물질인 PMA와 혼합하여 처리 한 경우 상승효과 작용으로 과민반응과 천식, 면역 관련 유전자의 발현을 강하게 유도하였다. 이는 유청단백질의 주요 성분 중 하나인 lactoferrin이 면역기전에 중요한 역할을 하고 있다는 결과로 사료된다. Bovine lactoferrin is well known as biological activator in defense mechanism related some cells. In this study, we was investigated about the immune modulator as a role of lactoferrin through the transcriptional regulation of genes associated with hypersensitivity such as allergy, athma and inflammatory disease. Effects of inflammatory reaction of bovine lactoferrin was carried out by RT-PCR analysis from isolated total RNA treated with lactoferrin 0, 10, 50, 100, 500 ${\mu}g/mL$ and PMA 100 ng/mL. The expression of the TYROBP, PITPNA, IL-10, SLP1, DC-stamp and ICAM-1 mRNA were increased by synergy effect of bovine lactoferrin and PMA. The results of RT-PCR showed that bovine lactoferrin and PMA had an effect of immune modulator by enhancement of TYROBP, PITPNA, SLP1, DC-stamp, IL-10 and ICAM-1 gene transcription in U937, Mutz-3 and NK92 cells, respectively. Bovine lactoferrin showed a potential of biological function which could be used for industrial applications as a material of food and pharmaceutical.
분리기술, 열역학 : 고압 아임계수 내에서 PET의 분해
정승희 ( Seung Hee Chung ),이정훈 ( Jung Hoon Lee ),심재진 ( Jae Seong Kim ),김재성 ( Jae Seong Kim ),김선욱 ( Sun Wook Kim ) 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.6
To investigate the decomposition kinetics of poly(ethylene terephthalate) the high pressure molten-polymer injector has been devised. Using the experimental apparatus equipped with batch reactor and high pressure molten-polymer injector the decomposition of PET has been performed at constant pressure of 250 bar and 300, 320, 340℃, respectively. At each temperature conditions the conversions after initial 1 minute have shown very high values such as 76-90%. As the temperature increases the conversion reaches more than 98% at 10 minutes. Based on the second order reaction model the reaction rate constants have been obtained. We can calculate the conversions within 2% errors utilizing optimized rate constants. The activation energy for the decomposition of PET at subcritical conditions has shown to be 54.4kJ/㏖.
요내반족 변형에 대한 재건수술의 임상적 및 방사선학적 결과 분석
정홍근,박재용,이동오,엄준상,정승희,Jung, Hong-Geun,Park, Jae-Yong,Lee, Dong-Oh,Eom, Joon-Sang,Chung, Seung-Hee 대한족부족관절학회 2014 대한족부족관절학회지 Vol.18 No.2
Purpose: Reconstructive surgeries for equinocavovarus foot deformities are quite variable, including hind-midfoot osteotomy or arthrodesis, soft tissue procedure, tendon transfers, etc. Comprehensive evaluation of the deformity and its etiology is mandatory for achievement of successful deformity correction. Few studies in this field have been reported. We report on the clinical and radiographic outcome of reconstruction for cavovarus foot deformities. Materials and Methods: The study is based on 16 feet with cavovarus foot deformities that underwent bony and soft tissue reconstructive surgery from 2004 to 2008. We evaluated the etiologies, varieties of surgical procedures performed, pain score, functional scores, and patient satisfaction and measured the radiographic parameters. Results: The average age at the time of surgery was 39.4 years old, with a male/female ratio of 9/4 and an average follow-up period of 23.9 months (range, 12~49 months). The etiologies of the cavovarus deformity were idiopathic 7 feet, residual poliomyelitis 5 feet, Charcot-Marie-Tooth disease 2 feet, and Guillain-Barre syndrome and hemiplegia due to cerebrovascular accident sequela 1 foot each. Lateral sliding calcaneal osteotomies were performed in 12 feet (75%), followed by Achilles tendon lengthening and plantar fascia release in 11 feet (69%), and first metatarsal dorsiflexion osteotomy/arthrodesis and tendon transfer in 10 feet (63%). Visual analogue scale pain score showed improvement, from an average of 4.2 to 0.5 points. American Orthopaedic Foot and Ankle Society ankle-hindfoot score showed significant improvement, from 47.8 to 90.0 points (p<0.05). All patients were satisfied. Ankle range of motion improved from $27.5^{\circ}$ to $46.7^{\circ}$. In radiographic measurements, calcaneal pitch angle improved from $19.1^{\circ}$ to $15.8^{\circ}$, Meary angle from $13.0^{\circ}$ to $9.3^{\circ}$, Hibb's angle from $44.3^{\circ}$ to $37.0^{\circ}$, and tibio-calcaneal axis angle from varus $17.5^{\circ}$ to varus $1.5^{\circ}$ Conclusion: We achieved successful correction of cavovarus foot deformities by performing appropriate comprehensive reconstructive procedures with improved functional, radiographic measures and high patient satisfaction.
Na Young Kim(김나영),Moo-Sang Kim(김무상),Sung Hee Jung(정승희),Myoung Sug Kim(김명석),Mi Young Cho(조미영),Joon Ki Chung(정준기),Sang Jung Ahn(안상중) 한국생명과학회 2017 생명과학회지 Vol.27 No.11
본 연구의 목적은 넙치 인지질가수분해효소(PLC- δ1) 3가지 타입의 세포내 특성을 규명하고자 하였다. 일반적으로 인지질가수분해효소(PLC)의 신호전달경로는 핵, 세포막, 세포질에 분포한다고 알려져 있으나, 핵내 위치 메커니즘은 여전히 불분명하다. PoPLC-δ1A, PoPLC-δ1B (Sf)과 PoPLC-δ1B (Lf)의 3타입의 유전자들은 각각 핵위치 신호(NLS)와 핵방출서열(NES)을 포함하고 있다. 본 연구에서는, 넙치 3가지 타입 인지질가수분해효소(PLC-δ1)의 세포내 위치이동 메커니즘 분석을 위해 GFP 벡터에 유전자를 삽입하여 ionomycin과 thasogargin처리 후 세포위치와 이동양상을 공초점 레이저 주사현미경으로 관찰하였다. PoPLC-δ1A는 PoPLC-δ1B (Lf)와 PoPLC-δ1B (Sf)가 원형질막에 국한되어 분포할때 세포질과 세포막보다 세포 소기관에 분포되어 있었다. PoPLC-δ1B (Lf) 및 PoPLC-δ1 (Sf)이 핵 세포질내 이동양상을 보이지 않을 때, PoPLC-δ1A은 ionomycin과 thapsigargin 처리에 의해 핵 내에 축적되는 양상을 나타냈다. 이런 결과는 손상되지 않은 기능적 NES 서열을 포함하는 PoPLC-δ1A가 어류에서 핵 세포질 내 왕복 및 이동의 주된 역할을 한다는 것을 보여주고 있다. The purpose of this study was to investigate the cellular characterization of phospholipase C-δ1 in olive flounders (Paralichthys olivaceus). In general, phospholipase C signaling pathways are distributed in nuclei at plasma membranes and in cytoplasms, although the pathways" nuclear localization mechanisms are unclear. P. olivaceus duplicates type-A PoPLC-δ1 (PoPLC-δ1A), which has a high similarity to the human isoform PLC-δ; type-B PoPLC-δ1 (PoPLC-δ1B [Sf]), which has a low similarity to the human isoform PLC-δ and the alternative splice variant PoPLC-δ1B (Lf), which has a nuclear localization signal (NLS) and a nuclear export signal (NES) for nuclear imports and exports, respectively. This study confirmed the effects of the cellular localization and translocation of GFP-tagged PoPLC-δ1A, PoPLC-δ1B (Sf) and PoPLC-δ1B (Lf). It administered treatments of Ca<SUP>2+</SUP> ionophore ionomycin and endoplasmic reticulum (ER)–Ca2+ pump inhibitor thapsigargin to hirame natural-embryo (HINAE) cells. A laser-scanning confocal microscope was used. GFP-tagged PoPLC-δ1A was distributed to the cellular organelles, rather than to the cytoplasms and cytomembranes, when PoPLC-δ1B (Lf) and PoPLC-δ1B (Sf) were localized at the plasma membranes. The treatments of ionomycin and thapsigargin showed the accumulation of PoPLC-δ1A in the nuclei when PoPLC-δ1B (Lf) nucleocytoplasmic shuttling and PoPLC-δ1B (Sf) nucleocytoplasmic shuttling were not observed. The results were the first evidence that PoPLC-δ1A, which contains functional, intact NES sequences, has a main role in nucleocytoplasmic shuttling and translocation in fish.