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      • KCI등재
      • KCI등재

        다발성골수종 환자의 진단 및 치료효과 추적을 위한 혈청 유리형 경쇄 정량검사의 의의

        정선경,김명신1,임지향1,김용구1,한경자1,민창기2,민우성2,김명신,임지향,김용구,한경자,민창기,민우성 대한진단검사의학회 2008 Annals of Laboratory Medicine Vol.28 No.3

        Background : Free light chain (FLC) is widely used to evaluate B-cell proliferative diseases. Herein, we estimated the clinical usefulness of serum FLC in multiple myeloma (MM). Methods : Fifty-one patients were enrolled. We performed FLC analysis, protein electrophoresis (PEP), and immunofixation electrophoresis (IFE). FLC was measured using Toshiba 200 FR Neo with FREELITETM, and kappa/lambda (κ/λ) ratio was calculated. We compared these parameters in 41 patients with increased FLC before and after bortezomib treatment. Complete response (CR) was defined as the disappearance of monoclonal (M) protein in serum and/or urine as measured by IFE. Partial response (PR) was defined as ≥50% reduction of serum M protein. Early objective response (EOR) included both CR and PR. Minimal response (MR) was defined as 25-49% reduction of M protein and stable disease (SD) as <25% reduction. Results : Forty-one (80.4%) of the 51 patients studied revealed increment of FLC and the five patients with no increment revealed an abnormal κ/λratio. Especially, all of the light chain myeloma and non-secretory myeloma showed increased FLC concentrations. Among the patients with EOR, 72.4% (21/29) showed a normal or subnormal FLC concentration after the first cycle of treatment. Otherwise, PEP and IFE normalized in 24.1% (7/29) and 24.1% (7/29), respectively. The ratio of decreased FLC after the first cycle of treatment was significantly different between EOR and other response groups (MR, SD) (90.6% vs 51.8%, P=0.011). Conclusions : FLC was considered as a good diagnostic method in complement with PEP and IFE in MM, especially in light chain myeloma or non-secretory myeloma. Moreover, FLC is a useful monitoring tool because it reflects therapy results more rapidly owing to a short serum half-life. (Korean J Lab Med 2008;28:169-73)

      • KCI등재

        국민건강영양조사를 활용한 폐경 여성의 삶의 질에 영향을 미치는 요인 ; 폐경 10년 이후 여성을 중심으로

        정선경,박금옥,이윤희 한국융합학회 2022 한국융합학회논문지 Vol.13 No.4

        본 연구는 국민건강영양조사의 2014년도부터 2019년까지의 자료를 이용하여 페경 후 10년 이상 된 여성의 삶의 질에 영향을 미치는 요인을 확인하기 위한 복합표본 2차 분석연구이다. 연구대상자는 6,330명, 자료는 SPSS 25.0 프로그램으로 복합표본 빈도분석, t-test, ANOVA, 회귀분석을 실시하였다. 연구 결과, 폐경 이후 10년이 지난 여성의 건강 관련 삶의 질에 영향을 미치는 요인은 연령(F=30.625, p<.001), 교육수준(F=20.106, p<.001), 주관적 건강상태(F=187.925, p<.001, 활동제한( t=201.051, p<.001), 관절염(t=91.131, p<.001), 골다공증(t=4.709, p=.030), 악력 저하(t=22.151, p<.001), 스트레스 인지(F=32.775, p<.001), 우울증(t=20.117, p<.001)이었고 그 설명력은 35.1%이었다(F=110.393, p<.001). 폐경 이후 여성의 삶의 질을 향상시키기 위해서는 폐경 초기부터 관련 요인들에 대한 지속적인 평가와 삶의 질 향상을 위한 노력이 필요할 것으로 사료된다. This study was conducted to identify the factors affecting the quality of life of women over 10 years after menopause using data from 2014 to 2019 of the National Health and Nutrition Examination Survey. The subjects were 6,330. The data were analyzed by frequency analysis, t-test and multiple regression analysis using SPSS 25. As a result of the study, the factors affecting the health-related quality of life of women 10 years after menopause were age(F=30.625, p<.001), educational level(F=20.106, p<.001), perceived health status(F=187.925, p<.001, activity limitation(t=201.051, p<.001), arthritis(t=91.131, p<.001), osteoporosis(t=4.709, p=.030), hand grip strength(t=22.151, p<.001), perceived stress(F=32.775, p<.001), and depression(t=20.117, p<.001). The factors accounted for 35.1%(F=110.393, p<.001). In order to improve the quality of life of postmenopausal women, it is necessary to continuously evaluate and improve the factors affecting the quality of life from the early menopause.

      • KCI등재

        『聊齋志異』의 생태적 세계관과 의미 고찰 -人과 物의 관계성을 중심으로-

        정선경 동아시아고대학회 2019 동아시아고대학 Vol.0 No.55

        Looking over literary works which are filled with China’s own ecological imagination and awareness of life, I searched the values and meanings which can be shifted from classics to modern times. At this point in time when the ecological unbalance problem rises seriously and a new understanding of humanities on Human, I try to examine how humans have balanced their life with the otherness and will build complementary relations with them in the future. In this paper, ecological views projected in Ghosts and Wizards(『聊齋志異』) which is a representative collection of short stories in the Qing Dynasty Period are classified into three types and the characteristics of their awareness of life are discussed. The ecological imagination sought by Pu Songling is analyzed into what meanings were implied according to the method of relations between humans and otherness. First of all, the symbiosis consciousness and interdependency can be found from the reciprocal relationship between humans and otherness. A warning to the human cruelty and a longing for the ideal world can be found from the oppositive relationship. The pursuit of equality of life values by collapsing the disconnected boundary can be found from the inter-compatible relationship. It is necessary that we should agonize seriously over life and try to live in symbiosis at every level in order to pursue the balanced compromise point where human can coexist with nature. The reinterpretation of the relationship between humans and otherness from the viewpoint of ecological imagination must be not only an argument on life at the dimension of biology but also an effort of worth for the restoration of social and cultural relations between humans and otherness. 본 논문은 중국 고유의 생태적 상상력과 생명의식이 담겨진 작품을 살펴보면서 고전에서 현대로 변통될 수 있는 생태적 세계관과 의미를 탐색하고자 했다. 생태학적 불균형 문제가 심각하게 대두되고 ‘인간’에 대한 새로운 인문학적 이해가 시도되는 현시점에서, 인간은 타자와 어떻게 생명의 균형을 이루어 왔고 어떻게 상보적인 관계로 나갈 수 있는지 살펴보고자 했다. 『聊齋志異』는 지괴와 전기의 계통을 잇는 청대의 대표적인 문언 단편소설집이다. 『요재지이』에 투영된 생태적 세계관의 유형을 세 가지로 분류하고 생명의식의 특징을 논의했다. 포송령이 추구했던 생태적 상상력은 인간과 이물이 관계 맺는 방식에 따라 어떤 의미를 함축하고 있는지 분석했다. 먼저 인간과 이물의 호혜적 관계에서는 공생의식과 상호의존성을, 대립적 관계에서는 인간의 잔악함에 대한 경고와 이상세계에 대한 갈망을, 호환적 관계에서는 단절된 경계를 와해시켜 생명 가치의 평등함을 추구하려는 의미를 살필 수 있었다. 인간과 자연이 공존할 수 있는 균형있는 절충점을 모색하기 위하여 생명에 관해 진지하게 고민하고 공생을 위한 다각도의 노력이 필요하다. 생태적 상상력의 관점에서 인간과 이물의 관계를 재해석하는 것은 단지 생명에 대한 생물학적 차원의 논증을 넘어서 인간과 타자의 사회문화적 관계 회복을 위한 실질적인 노력의 일환이라고 할 수 있다.

      • KCI등재

        中ㆍ韓 神仙說話의 類型 및 敍事構造 比較考察

        정선경 한국중국소설학회 2002 中國小說論叢 Vol.15 No.-

        神仙思想是不死的思想. 神仙說話是將不願死去而希望成爲神仙的慾望加以形象化的文學作品. 形成神仙說話最根本的思想是神仙思想, 該思想是想從現世中追求永生的道敎形成的根本所在. 本文列擧了神仙傳記集-≪列仙傳≫和韓國最著名的神仙傳記集-≪海東異蹟≫中的神仙說話, 對其類型和敍事結構進行比較和思考, 以幇助人們加深對中國與韓國初期敍事文學的理解. 本文在說明構成神仙說話根本思想的神仙思想的理論背景後, 闡述了神仙說話在中國與韓國産生的地區、背景和發展過程. 作者以≪抱朴子≫[內篇]裏的神仙三品說爲依據進行分類, 幷說明了各類型的特點. 作者在最後章節將神仙說話分爲“得仙的敍事結構”與“≪史傳≫的敍事構造”, 敍述了初期神仙說話裏的敍事體系特征. 總之, 作爲神仙思想基礎的神仙說話, 是隨着現世中追求永生的道敎的形成與發展而變遷. 此間, 타在中國與韓國兩地朝着各自獨特的方向發展. 神仙說話如果只停留在“無聊趣味故事”的層面上, 那마타只能在特定時期和階層流行一時而消聲匿迹. 但是, 神仙說話在時間、空間、文化等逈異的環境裏得以持續發展, 是因爲타的本質是出自人類潛在意識中的無限慾望. 這就是能將神仙視爲現實與經驗之談的理由.

      • 관상동맥질환자의 퇴원 후 추후관리 내용분석

        정선경,송라윤 충남대학교 간호과학연구소 2005 충남대 간호학술지 Vol.8 No.2

        Coronary artery disease (CAD) patients are facing life-long commitment to change their health habits. It is necessary for these patients to maintain their health habits even after discharge by nursing intervention. The purpose of this study was to analyze the follow-up nursing management consisting of personal interviews and telephone coach after discharge to CAD patients. The data were collected from 35 CAD patients between June, 12, 2005 and October, 19, 2005. Data were processed by SPSSWIN V.13.0 program with descriptive statistics. The results of this study were as follows: 1. The proportion of the subjects were male patients(82.9%), married(94.3%), over high school(71.4%), having a job(71.4%), middle socio-economic state(65.7%) and everage age was 55.4 years. 2. The average hospital days for the subjects were 3.0days, with 20.31 months for the period since their diagnosis of CAD. About 85.7% of the subjects reported no family history of heart disease, while 80% is diagnosed for angina among whom 57.1% has comobity of diabetes or hypertension. 22.9% are smokers, 48.6% are drinking alcohol more than once a week, 65.7% drinks coffee, and 34.3% are doing exercise regularly. Most subjects (91.4) never receive CAD related formal education. 3. The checklists for patients' counselling areas by personal interview and telephone couch includes exercise, medication, stress management, diet, weight control, smoking cessation, glucose control, sex behavior, hospital visit schedule, and changes in their employment. 4. According to time frame for their specific counselling needs, the areas of medication, diet, weight control, glucose control, and sex behavior were the main concern during the first 2 weeks after discharge. The areas of exercise and smoking cessation was the focus of counselling during the following 2 weeks. After 4 weeks of discharge, the major concern of the subjects was about stress management. In conclusion, there were major areas of concern for CAD patients after discharge as reported by a personal interview and telephone couch, and those concerns were different according to the time frame after their discharge. There is a need to develop the formal nursing management program that can be applied easily and effectively to CAD patients at outpatient clinic after discharge according to their education needs. The study findings supported the potential cost-effectiveness of the follow-up nursing management program utilizing a nurse-led interview and a series of telephone couch.

      • KCI등재

        논문 : 한(韓),중(中) "환(幻)" 서사(敍事)의 시공간적(時空間的) 서술미학(敍述美學) ―《열선전(列仙傳)》,《태평광기(太平廣記)》,《어우야담(於于野譚)》,《해동이적(海東異蹟)》을 중심으로

        정선경 중국어문학회 2010 中國語文學誌 Vol.33 No.-

        In this paper, I reviewed the aesthetic characteristics of Korean and Chinese fantasy literature focused on time and space in the viewpoint of the culture of 21 century east asian society and discussed the meanings of them in the position of modern age. The space-time characteristics of Korean and Chinese fantasy literature was examined and the aesthetic characteristics embeded in the east asian fantasy literature was revealed by analyzing examples in the original sources. For the purpose of these, the aesthetic characteristics of both Korean and Chinese literature was investigated with " Lie Xian Zhuan(《列仙傳》)" which is the oldest tale of China on Taoist hermits with miraculous powers, "Tai Ping Guang Ji(《太平廣記》)" which is called the ocean of Chinese novelists, "Eo U Ya Dam(《於于野譚》)" which is the first Korean historical story book and "Hae Dong I Jeok(《海東異蹟》)" which is the oldest tale of Korea on Taoist hermits. Especially, "Tae Pyong Kwang Ki" has not only a tremendous value in the history of Chinese novels but also great influences on Korean stories, novels and even other east asian literature. Thus it is the most important reference and we cannot help taking a careful look at it. First of all, the origin and development of Korean and Chinese fantasy literature was examined. In the section of "Aesthetics of Description of Time in Fantasy Literature", the narrative characteristics of dissolving the physical and objective time into the personal and relative time and restructuring it with literal imaginations was considered. In the sectionof "Aesthetics of Description of Space in Fantasy Literature", It was considered that the hyper-space in a work exists in the real world where we live with psychological desire. Fantasy originates from the point where physically absent but psychologically present desire is visualized. Fantasy is a gap between reality and surreality. Fantasy is also the contact point of reality and surreality.

      • KCI등재

        신생아집중치료실 간호사의 캥거루 돌보기에 대한 인식과 장애

        정선경,김태임 한국아동간호학회 2016 Child Health Nursing Research Vol.22 No.4

        Purpose: To investigate the perception and barriers of Kangaroo-Mother Care (KMC) among nurses in Neonatal Intensive Care Units (NICU). Methods: Participants were 131 nurses working in NICU who completed self-report questionnaires which included information regarding perception, barriers, and practice of KMC. Collected data were analyzed using SPSS 18.0 program for descriptive statistics, t-test, ANOVA, and Pearson correlation coefficients. Results: Of the participants, 33.6% reported the practice of KMC in their NICU, with 75.6% wanting to receive training in KMC and 31.3% having received KMC education. Most of the participants agreed that KMC enhances attachment, parental confidence, and effective breast feeding but they reported a negative perception in providing KMC for premature infants weighing less than 1000 grams or intubated premature infants. Major barriers to practicing KMC were safety of infants, possible work overload for nurses, as well as absence of consistent guidelines. Barriers to KMC among nurses who received the KMC training were lower than nurses who did not receive the KMC training (t=-2.11, p=.037). Conclusion: Education program and standardized clinical practice protocol should be developed to foster the positive perception and to reduce nurse barriers to KMC.

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