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정범선,김정요,박진서 대한체질인류학회 2021 대한체질인류학회 학술대회 연제 초록 Vol.64 No.-
시상 밑 핵(subthalamic nucleus)의 대뇌심부자극술(deep brain stimulation)을 부작용 없이 정확히 시행하기 위해서, 신경외과 의사는 비스듬한 면의 자기공명영상(MRI)을 올바르게 이해해야 한다. 이 연구의 목적은 실제 빛깔의 시신 부피3차원영상(volume model)을 만들어서, 비스듬한 면의 자기공명영상을 판독하는 것을 돕는 것이다. 시신 연속절단면영상을 재구성해서, 화적소크기(voxel size) 0.5 mm × 0.5 mm × 0.5 mm를 갖는 실제 빛깔의 부피3차원영상을 만들었다. 대뇌심부자극술을 받은 환자 31명의 수술 전 자기공명영상과 수술 후 컴퓨터 단층영상을 바탕으로, 대뇌에 삽입하는 전극의 들어가는 지점과 도착하는 지점을 정하였다. 시신 부피3차원영상을 컴퓨터로 잘라서 수평, 관상, 시상 단면과 더불어 비스듬한 단면을 만들어서 중요한 해부학 구조물을 확인하였다. 전극을 잘못 넣었을 때 부작용이 생길 수 있는 구조물의 위치도 확인하였다. 구역화 영상으로도 비스듬한 단면을 만들어서 이해를 도왔다. 시신 부피3차원영상은 실제 빛깔이고 해상도가 높아서, 자기공명영상에서 확인하기 어려운 구조물도 확인할 수 있었다. 부피3차원영상을 홈페이지(neuroanatomy.kr)에서 내려 받으면 원하는 환자의 수술 정보와 비교해 봄으로써, 해부학적 이해를 도울 수 있다.
Real-Color Volume Models Made from Real-Color Sectioned Images of Visible Korean
정범선,박진서 대한의학회 2019 Journal of Korean medical science Vol.34 No.10
Background: Volume models made from magnetic resonance images on computed tomographs can produce horizontal, coronal, sagittal, and oblique planes that are used widely in clinics, although detailed structures cannot be identified. Existing real color volume models are mostly commercial and their production methods have not been released. The aim of this study was to distribute free of charge, real-color volume models produced from sectioned images with the production method. Methods: The original voxel size of sectioned images was increased appropriately so that the volume model could be handled by typical personal computers. By using Dicom Browser and MRIcroGL, the sectioned images were processed to become the volume models. Results: On the MRIcroGL, the resultant volume model with the voxel size of 0.5 × 0.5 × 0.5 mm3 could be displayed and freely rotated. By adjusting variables of the software, desired oblique planes could be produced instantly. With overlay function, a model of segmented structure can be overlapped to the entire volume models. The sectioned images with high quality and the segmentation data of Visible Korean enabled the identification of detailed anatomical structures on the planes. Conclusion: The volume models can be used by medical students and doctors for learning sectional anatomy. Other researchers can utilize the method of this study to produce volume models from their own sectioned images.
Vicious Cycle between Brain and Muscle
정범선 대한의학회 2019 Journal of Korean medical science Vol.34 No.9
Vicious Cycle between Brain and Muscle
Advanced Sectioned Images of a Cadaver Head with Voxel Size of 0.04 mm
정범선,한미란,하동환,박진서 대한의학회 2019 Journal of Korean medical science Vol.34 No.34
Background: The sectioned images of a cadaver head made from the Visible Korean project have been used for research and educational purposes. However, the image resolution is insufficient to observe detailed structures suitable for experts. In this study, advanced sectioned images with higher resolution were produced for the identification of more detailed structures. Methods: The head of a donated female cadaver was scanned for 3 Tesla magnetic resonance images and diffusion tensor images (DTIs). After the head was frozen, the head was sectioned serially at 0.04-mm intervals and photographed repeatedly using a digital camera. Results: On the resulting 4,000 sectioned images (intervals and pixel size, 0.04 mm3 ; color depth, 48 bits color; a file size, 288 Mbytes), minute brain structures, which can be observed not on previous sectioned images but on microscopic slides, were observed. The voxel size of this study (0.04 mm3 ) was very minute compared to our previous study (0.1 mm3 ; resolution, 4,368 × 2,912) and Visible Human Project of the USA (0.33 mm3 ; resolution, 2,048 × 2,048). Furthermore, the sectioned images were combined with tractography of the DTIs to elucidate the white matter with high resolution and the actual color of the tissue. Conclusion: The sectioned images will be used for diverse research, including the applications for the cross sectional anatomy and three-dimensional models for virtual experiments.