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- 저자 : 정문현(Moon Hyoun Chung) (검색결과 2 건)
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김성민(Seong Min Kim),최윤호(Yoon Ho Choi),남택서(Taik Seo Nam),배현주(Hyun Joo Pai),오명돈(Myoung Don Oh),정문현(Moon Hyoun Chung),송영욱(Yeong Wook Song),최강원(Kang Won Choe) 대한내과학회 1990 대한내과학회지 Vol.39 No.6
N/A Polymyositis is a disorder of unknown etiology characterized by an inflammatory myopathy involving striated skeletal muscle. When characteristic skin lesions accompay the myositis, patients are diagnsed as dermatomyositis. We analyzed clinica1 and laboratory features of 100 patients with dermatomyositis polymyositis who were admitted to the Seoul National University Hospital hom January, 1981 to January, 1989. The observed results were as follows 1) The range of age was from 6 to 74 years, and the most frequent age group WBS the third decade (23.0% of all cases) and the next, the second decade (19.0% of all cases). Male to female ratio was 27:73. 2) Of the 100 patients, 32.0%. was classified as group I, 37.0% as group II, 9.0% as group III, 5.0g as group IV and 17.0% as group V. Among the patients, diagnosis was definite in 52.0% and probable in 48.0%. 3) Proximal muscle weakness was noted in 74%, myalgia 47%, arthralgia 47%, skin rash 52ii, dysphagia 20%, dysphonia 7%, alopecia 22%, Raynaud`s phenomenon 22%, and fever 48% as presenting symptoms at the time of diagnosis. 4) Serum CPK level was elevated in 62.0% SGOT 78.0%, SGPT 61.0%, and LDH 99.0%. 5) The electromyography was done in 95 patients, which revealed small polyphasic motor units (78.9%), fibrillation (63.2%), positive sharp wave (71.6%), in- creased insertion activity (11.6%), increaseed resting potential (3.2%), high frequency bizarre discharge (20.0%). A normal EMG was seen in 12.6%. 6) The muscle biopsy was done in 83 patients, which light microscopic findings were as follow: degeneration (56.6%), regeneration (10.8%), fibrosis (4.8%), necrosis (12.0%), inflammation (53.0%), vasculitis (18.1%), crossseetional diameter variation (30.1%), internalization of nuclei (16.1%). A normal pathology was noted in 8.4% 7) Antinuclear antibody was found in 19.0%, rheumatoid factor 23.8%, LE cell 9.1%, anti-ds-DNA antibody 9.3%, cryoglobulin 34.4%, false positive VDRL 1.1%, and decreased cnmplement level 8.7% ANA was noted in 70.6% of patients of group V, whereas 4.8% in patients of other group. 8) Heart involvement was seen in 36.0%. Congestive heart failure was detected in 4:0%, nonspecific ST-T change 12.0%, bundle branch block 5.0%, low voltage 9. 0%, poor R progression 3.0%, sinus arrythmia 2.0%, atrial fibrillation 2.0%, VPB 5.1%, SVPB 2.0%, and pericarditis 10.0%. Interatitial pulmonary disease was noted in 18.0% on chest X ray. FVC w as abnormal in 74:0% of 50 patients tested, abnormal DLCO was in 73.3% of 15 patients tested, and abnormal FEV1/FVC was in 18.0% of 50 patients tested. 9) Neoplasm were associated in 9 patients, 5 polymyositis and 4 dermatomyositis patients. Sites of neoplasm were stomach cancer (4 cases), colon cancer (1 case), lung cancer (1 case), nasopharyngeal cancer (1 case), lymphoma (1 case), and hepatocellular cancer (1 cancer). Mean age of the group III was 65 years, which was high relative to other group. 10) 17 patients were associated with other connective tissue disease, which were systemic sclerosis (S cases), systemic sclerosis and SLE (1 case), SLE (5 cases), RA (2 cases), hyperthyroidism (1 case), and ITP (1 case). Male to female ratio was 1:16. Polymyositis to dermatomyositis ratio was 10:7. 11) There were 14 patients who were affirmed to die. Cause of death was respiratory failure (4 cases), sepsis (3 cases), CHF (3 cases), asphyxia (1 case), sudden respiratory arrest (1 case), malignancy (1 case), suicide (1 case).
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김성민,최강원,정문현,배현주,오명돈,백경란,김양수,신형식 대한감염학회 1991 감염 Vol.23 No.3
We studied 61 cases of nosocomial pneumonia whose etiologic agents were identified by a positive bacterial culture from blood, pleural fluid, TTA material and serology. Patients were hospitalized to the Seoul National University Hospital between January, 1983 and July, 1989. Two third of the patients had aerobic gram-negative bacterial pneumonia. Klebsiella and other members of the family Enterobacteriacae predominated. Their over-all mortality was 37.7%, which were dependent on the severity of underlying disease.
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