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β-sheet mediated self-assembly of poly(aspartamide) grafted with oligo(L-valine)
정나슬,한사라,정재현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Nano-sized self-assemblies formed with amphiphilic block and graft copolymers have been extensively studied for targeted drug delivery. This study reports novel strategy to prepare self-assemblies with unique morphology by varying packing structure of beta sheets. Specifically, the amphiphilic graft copolymers composed of poly(2-hydroxyehtyl aspartamide) (PHEA) as the hydrophilic backbone and oligo(L-valine) as the grafted hydrophobic chain were synthesized by a ring-opening polymerization of the Val-NCA to backbone polymer. Then, the effect of degree of substitution (DS) and polymerization (DP) on self-assemblies of PHEA-g-oligo(L-valine)s were investigated in an aqueous solution. This study discovered that the beta-sheets of polymers are formed favorably by increasing of DS, while the structural transition of self-assemblies is influenced dominantly by DP.
한사라,정나슬,지윤숙,정재현 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Nano-sized self-assemblies formed with amphiphilic graft copolymers have been extensively studied for drug delivery. This study reports a novel strategy to prepare biomimetic self-assemblies by varying packing of α-helix and β-sheet which are secondary structures. Specifically, the amphiphilic graft copolymers, PHEA-g-oligo(L-leucine) composed of poly(amino acid)s derivative and oligo(L-leucine) which to form α-helix as the grafted hydrophobic chain were successfully synthesized. In parallel, PHEA-g-oligo(L-valine) was also synthesized to form β-sheet of the grafted hydrophobic chain. The self-assembly ratio of α-helix and β-sheet formed in PHEA-g-oligo was simulated equal to the secondary structure content of EGF, and its contents were 2.9 % and 28.5 %, respectively. Finally, EGF was introduced with PHEA-g-oligo and applied to cosmeceuticals to efficiently deliver EGF to the human skin. This strategy would applicable to prepare cosmeceutical system.
Sponge-like lipophilic gel cross-linked with poly(aspartamide) designed for VOCs absorbing
신성규,정나슬,조성우,정재현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
The lipophilic gel has been studied for absorbent for various organic solvents. In this study, we present an engineered lipophilic sponge gel consisting of silicon back bone cross-linked with poly(succinimide) grafted methacrylates for absorbing volatile organic compounds (VOCs). The absorption behavior of the lipophilic gel was examined by varying of degree of substitution of acrylates in the cross-linker. The swelling behavior of the lipophilic gel in VOCs solution such as toluene could be controlled with expansion ratio (S) and elastic modulus (E) of the gel. In addition, VOCs vapor absorbency of lipophilic sponge gel was analyzed using residual VOCs vapor by GC. Overall, this new strategy to prepare the super lipophilic gel using the graft cross-linking polymer would be directly used for designing effective VOCs absorbing material.
A soft mask pack enhanced adhesion strength by self-transforming
임준우,정나슬,권혜진,정재현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Previous studies of mask packs have focused on the carrying and release behavior of functional materials to be delivered. Recently, functional mask pack researches have been studied to emphasize the convenience of users and the new fiber polymer materials. Particularly, the 4D mask pack products have been developed by improving facial adhesion by incorporating techniques such as incision, hook and slip prevention. A hydrogel-based soft material similar to the physical properties of extracellular matrix (ECM) has been studied as a facial mask material. In this study, the hydrogel mask was designed to 4D self-transform using a multi-layered and compartmented hydrogel.
Tuning the mechanical properties of a functional alginate microgel for stem cell-instructed Delivery
오승주,정나슬,임준우,한사라,정재현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
The cell-instructed delivery system was designed to control the release behavior, according to the cell traction force by tuning the mechanical properties of the cell delivery carrier. First, alginate molecules were substituted with methacrylates and mixed with pure alginate to prepare microgel crosslinked with Ca2+ ions. Then, the interpenetrating covalent cross-links were incorporated in an ionically cross-linked gel. Controlling the amount of chemical cross-links tuned the microgel with varying of stiffness and toughness. Finally, the stem cells were introduced in the microgel functionalized with sulfates molecules for recapitulating the heparin structure. The stem cells differentiated were hatching and released in the functional alginate microgel with the designated work to fracture and elastic modulus. Overall, this results will be useful in designing cell-instructed delivery by systematically controlling the mechanical properties of the gel and the activity of growth factors.
β-Sheet 구조를 갖는 폴리아미노산 유도체의 자기조립 현상
박일우,정나슬,한사라,오승주,김희진,정재현 한국고분자학회 2019 폴리머 Vol.43 No.4
양친매성 공중합체로 형성된 자기조립 나노입자는 치료 효능을 최대화하기 위한 효과적인 약물전달체로 활발하게연구되고 있다. 본 연구에서는 베타 시트 구조의 패킹 정도를제어하여 다양한 형태의 생체모방 자기조립체를 제조하였다. 친수성 폴리아미노산 유도체에 베타 시트 구조를 형성할 수있는 발린 분자를 접목하여 그래프트 공중합체, PHEA-g-oligo (L-valine)를 합성하였다. 이렇게 합성한 그래프트 폴리아미노산 공중합체는 수용액상에서 나노미터 크기를 갖는 안정한자기조립체를 형성하였다. 자기조립체의 베타 시트 함량은 발린 분자의 접목도(DS)에 주도적으로, 자기조립체의 형태는 중합도(DP)에 주도적으로 영향을 받는 것이 확인되었다.
베타시트 구조가 도입된 폴리아미노산 유도체의 피부활성에 관한 연구
신성규,한사라,정나슬,지윤숙,정재현 한국응용과학기술학회 2020 한국응용과학기술학회지 Vol.37 No.6
본 연구에서는 발린분자가 접목된 고차구조 폴리아미노산 자기조립체를 활용하여 피부성장인자의 피부활성에 관한 연구를 진행하였다. 친수성 폴리아미노산 유도체에 베타-시트를 형성할 수 있는 발린 분자를 접목하여, 접목도(degree of substitutes)와 중합도(degree of polymerization)가 조절된 양친성 폴리 아미노산을 합성하였다. 고차구조 폴리아미노산과 함께 자기조립 되었을 때 상피세포성장인자는 프로콜라겐 생합성이 20% 향상되었고 티로시나아제 활성 저해능은 6.5배 증가함을 확인하였다. 고차구조 폴리아미 노산 자기조립체를 활용하면 다양한 단백질 성장인자의 구조 안정성을 확보하여 효과적인 피부개선이 가능한 기능성 화장품 물질뿐만 아니라 나아가 의약품으로도 사용 가능하리라 기대된다. In this study, a synthesized poly(amino acid) self-assembly grafted with valine molecules was investigated on the skin activity of skin growth factors. The amphiphilic grafted poly(amino acid) derivatives were successfully synthesized by varying of degree of substitutes(DS) and polymerization(DP) with valine molecules forming a β-sheet structure. Then, the pro-collagen biosynthesis of EGF(epidermal growth factor) was improved by 20%, and the inhibitory ability of tyrosinase activity was increased by 6.5 times by self-assembling of EGF with the poly(amino acid)s having β-sheet structures. This strategy of preparing protein self-assembly with poly(amino acid) derivatives will help improve the stability of protein growth factors and use it in medicals as well as cosmeceuticals through skin improvement.