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Zhenlong Zheng,노미령,Junjei Piao,이지혜,김송애,김수찬,정기양 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2
Purpose: Dermatofibrosarcoma protuberans (DFSP) carries a translocation resultingin the collagen type I alpha 1 (COL1A1)-platelet-derived growth factor beta (PDGFB) fusion gene, which is responsible for PDGFB activation. The purpose of this study is to evaluate the clinicopathological, genetic, and therapeutic features of DFSP in Korean patients. Materials and Methods: Clinicopathological featuresof 37 patients with DFSP were reviewed. Multiplex reverse transcriptase-polymerase chain reaction (PCR) was carried out in 16 patients using formalin-fixed, paraffin-embedded tissues and specific primers for COL1A1 and PDGFB. Results: The mean age of 37 patients was 37.4 years old. The most common tumor location was the trunk. All patients were treated primarily with surgery: 34 (91.7%) cases with Mohs micrographic surgery (MMS) and 3 (8.3%) cases with wide local excision. The median follow-up time was 33.7 months. Two patients, one in each treatment group, demonstrated local recurrence during the follow-up period. The COL1A1-PDGFB fusion gene was expressed in 14 (87.5%) cases, demonstrated by reverse transcriptase PCR analysis. No association was found among the differentCOL1A1-PDGFB fusion transcripts, the various histological subtypes and clinical features. Conclusion: Our results support the effectiveness of MMS in treating DFSP. The COL1A1-PDGFB fusion transcript was observed in 87.5% of patients. Therefore, COL1A1-PDGFB is a useful and accurate tool in diagnosing DFSP in Koreans.
이성호(Lee Sung-Ho),정기(Zheng Qi),김선국(Kim Sun-Kuk),주진규(Joo Jin-Kyu) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.8
As industrialization, urbanization and predominance of nuclear family continue to characterize the Korean society in a drastic departure from the past, the traditional 3 generation-family in which the eldest son would live together with his parents and his kids has become a rarity while alternative households inhabited individual elderly citizen or senior couples are increasing rapidly in numbers. As the elderly become more economically active and aware of the needs to take care of themselves rather than relying on their children, public interest and desire for silver town is on the rise. Accordingly, silver town projects have sprang up in diverse configurations in response to varying needs and different income levels of the senior citizens. However, it is noteworthy that silver town projects capitalized by private sector entities seek not only social contribution but also private gains as well. Silver town projects are affected by similar factors to those impacting conventional construction and development projects and always likely to fail under the exposure to several risks common to any investment initiatives in terms of abrupt economic slowdown or tightening of government regulation, which makes it essential to analyze risk factors that make or break a project by impacting the project viability. therefore this study investigated the risk factors of silver town projects and consequence of risk factors were also evaluated. As a results, important management factors of silver town project were determined. The result of this study can provide one of the key enablers to ensure success of silver town projects.