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녹용에 관한 연구(제 2 보) 녹용이 실험용백서의 성장에 미치는 영향에 대하여 (기일)
허금(Kum Haw),최숙형(Sook Hyung Choi),이해빈(Hae Bin Lee),정규찬(Kyu Chan Chung),고돈이(Don Iee Ko) 대한약학회 1960 약학회지 Vol.5 No.1
In order to know the effect on the growth of experimental rats, this, this experimental rats, this experiment was carried out on two groups of rats---a rice-diet animal group and a stock-diet animal group. Results of the growth experiment are shown in the tables 3 and 4, and growth curves are shown in the figures I and 2. The growth curves are shown in the figures 3 and 4. Based on the statistical analysis of growth rates, the male group on stock-diet was stimulated signficantly in its growth by adding antler. The female group on rice-diet was also significantly stimulated in growth by antler. The other groups are not significant but it seems likely that the growths were stimulated. As shown in table 7, the numbers of days when the body weight of the animals in each group became two times, three times, three times, and four times are discussed. This method. This method of analysis shows clearly the stimulation of growth by adding antler in each group in both sexes. It can be summarized that the antler stimulates the growth of the experimental rats but it is not discussed in this paper whether this stimulation in the growth might be due to calcium, vitamins and amino acids in antler or to an unknown growth factor.
문태철,정규찬,손건호,김현표,강삼식,장현욱 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
Tissue distributions and association of cyclooxygenase-2 (COX-2) with inflammatory have led us to search for COX-2 selective inhibitors from natural products. Conceptually, COX-2 selective inhibitors should be expected to retain anti-inflammatory efficacy by inhibition of PGs production while reducing or eliminating the gastric, renal and hemostatic side effects commonly associated with NSAIDs use. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of COX-2. To develope new COX-2 inhibitors from natural products, two-hundred crude drugs were Screened by inhibiting PGD₂ generation in bone marrow derived mast cells (BMMC). Among them, 6 methanol extracts of crude drugs such as, Bletillae rhizoma, Aconiti koreani rhizoma, Belamcandae rhizoma, Nelumbinis semen, Gleniae radix, Aurantii immatri pericarpium inhibited more than 85% of BMMC COX-2 activity at a concentration 2.5 ㎍/ml.
Flavonoids from the Aerial Parts of Lonicera japonica
Son, Kun Ho,Park, Jung Ok,Chung, Kyu Chan,Chang, Hyeun Wook,Kim, Hyun Pyo,Kim, Ju Sun,Kang, Sam Sik 영남대학교 약품개발연구소 1993 영남대학교 약품개발연구소 연구업적집 Vol.3 No.-
Seven flavonoids were isolated from the aerial parts of Lonicera japonica. Their structures were characterized as hydnocarpin 1, quercetin 2, ochnaflavone 3, ochnaflavone 4'-O-methylether 4, astragalin 5, isoquercitrin 6, and rhoifolin 7 by chemical and spectroscopic evidences.
Pinusolide from the Leaves of Biota orientalis as Potent Platelet Activating Factor Antagonist
Kim, Kyung A.,Moon, Tae Chul,Lee, Shin Woong,Chung, Kyu Chan,Han, Byung Hoon,Chang, Hyeun Wook 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
We investigated the effect of a new PAF antagonist pinusolide, isolated from the leaves of Biotα orientαlis, on PAF-induced [^(3)H]serotinin release from rabbit platelets, Hypotension and vascular permeability. Pinusolide (IC(50), about 5 × 10^(-6)M)inhibited specifically [³H]serotinin release from rabbit platelets when stimulated with PAF (5 × 10^(-8)M), but showed no effect when induced by ADP, collagen, and thrombin. It also inhibited PAF-induced hypotension in a dose-dependent manner in rats with no effect on the hypotension induced by acetylcholine, histamine and serotonin. The inhibitory effect of pinusolide on the PAF-induced vascular permeability is less specific than the induced hypotension. These results suggest that pinusolide may prove of therapeutic value in the treatment of hypotension and a molecular design of pinusolide analogues may provide the possibility of a new PAF specific antagonists.
Inactivation of Human Pleural Fluid Phospholipase A₂ by Dioscin
Beak, Suk Hwan,Kim, Sung Hwan,Son, Kun Ho,Chung, Kyu Chan,Chang, Hyeun Wook 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-
The natural product, spirostanol glycoside dioscin, was shown to directly inactivate human pleural fluid phospholipase A₂ (PLA₂). Inactivation was dose, and time dependent. The IC_(50) was estimated at 18 μM and virtually complete inactivation of the enzyme occurred at 50 μM. Using Michaelis-Menten kinetics, dioscin inactivated the enzyme by a competitive inhibitory manner, the apparent Ki value was 6.9×10^(-4)M. Reversibility was studied directly by dialysis method, the inhibition was reversible. Addition of excess Ca^(2+) concentration up to 8 mM did not antagonize the inhibitory activity of dioscin. Inactivation of several kinds of PLA₂ by dioscin, showed a broad range of PLA₂ specificity. These data suggest that inactivation of PLA₂ by dioscin is due to interaction with the active site of PLA₂ and may be a useful adjunct in the theraphy of inflammatory diseases.
문태철,박정옥,정광원,손건호,김현표,강삼식,장현욱,정규찬 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
Because of the potent effects of lipid mediators such as prostaglandins (PGs). leukotriens (LTs) and platelet activating factor (PAF) on a variety of cells and tissues. they are considered as major contributors to the process leading to inflammation and allergy. To pursue the mechanism of anti-in-flammatory activity of Lonuicerα jαponicα. we tested inhibitory effects of 7 flavonoids fron Lonicerα jαponicα on arachidonic acid cascade related enzymes. such as inflammmatory phospholipase A(2), cy-cloxygenase-1 and 2, 5-lipoxygenase, in bone marrow derived mast cells (BMMC), and lyso PAF- a-cetyltransferase in rat spleen microsomes. Anti-inflammatory activities of Lenicerα jαponicα are thought to be attributed at least in part to the inhibition of arachidonic acid cascade releated enzymes by fla-vonoids such as apigenin, luteo]in and quercetin.