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Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form
전태진,류성언,치엔,전하정 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1
Protein tyrosine phosphatase sigma (PTP) plays a vital role in neural development. The extracellular domain of PTP binds to various proteoglycans, which control the activity of 2 intracellular PTP domains (D1 and D2). To understand the regulatory mechanism of PTP, we carried out structural and biochemical analyses of PTP D1D2. In the crystal structure analysis of a mutant form of D1D2 of PTP, we unexpectedly found that the catalytic cysteine of D1 is oxidized to cysteine sulfenic acid, while that of D2 remained in its reduced form, sug-gesting that D1 is more sensitive to oxidation than D2. This finding contrasts previous observations on PTP. The cysteine sulfenic acid of D1 was further confirmed by immunoblot and mass spectrometric analyses. The stabilization of the cysteine sulfenic acid in the active site of PTP suggests that the formation of cysteine sulfenic acid may function as a stable intermediate during the redox-regulation of PTPs.
전태진,홍창권,노병인 ( Tae Jin Chun,Chang Kwun Hong,Byung In Ro ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6
N/A The authors performed a clinical study of 255 patients with εlopecia areata retrospecitively in order to evaluate the clinical manifestation and the effect of treatment with intralesional injection of triamcinolone acetonide suspension from August, 1986 to February, 1991. The results were as follows : 1. The age distribution showed a peak incidence in the third decade(15.5%, 116/255) and average age was 29.6 years. 2. The most common site of involvement was the occipital region(54.1%) in males and the temporal region(51.0%) in females. 3. The effect of treatment in the group treated with intralesional injection of triamcinolone acetonide revealed no significant difference from the group treated with intralesional injection of tramcinolone acetonide and topical application of minoxidil solutior. 4. The area of the bald patch revealed statistically significant correlation with effect of treatment. But the other factors such as sex, age, history of pervious episode, duration and number of lesions were not contributory. These findings suggested that alopecia areata predominantly developed in male and showed excellent therapeutic effect in cases of bald areas less than 5㎠
전태진,김명남,송계용,노병인 ( Tae Jin Chun,Myeung Nam Kim,Kye Yong Song,Byung In Ro ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5
Verrucous hemangioma is a variant of a capillary, carvernous, or mixed hemangioma which undergoes a reactive proliferative epidermal change. We report two cases which showed clinical and histopathologic findings of verrucous hemangioma. In both cases, reddish hemangiomatous lesions were present since birth and were verrucous crusty lesions of the right lower extremity. Skin biopsy revealed hyperkeratosis, acanthosis, and papilomatosis of the epidermis and proliferation and dilatation of capillaries in the upper dermis in addition to the capillary hemangioma in the deep dermis and subcutis.