우울증과 심혈관 질환

전태연,배치운 한국의학사 2000 診斷과治療 Vol.20 No.11

급성 및 만성 정신분열증에 있어 Chlorpromazine투여에 대한 Prolatin 값의 변화

전태연 가톨릭대학 (가톨릭신학대학) 대학원 1983 가톨릭大學醫學部 論文集 Vol.36 No.1

주요 우울장애에서 Cytotoxic T Lynphocyte Antigen(CTLA-4) 유전자의 다형성

전태연,배치운,김병균,채정호,박원명,김광수,유태열,한훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 세포의 면역 기능 조절에 관여하는 CTLA-4의 유전자 다형성을 분석하여 주요 우울장애와의 면역 유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-Ⅳ진단 기준에 따라 주요 우울장애로 진단된 환자 77명을 선정하였으며 가톨릭대학교 의과대학 조혈모세포은행에서 보유하고 있는 149명의 정상 한국인 자료를 대조군으로 사용하였다. 전혈에서 DNA를 추출하였으며 중합효소반응으로 CTLA-4유전자 exon 1 부위를 증폭한 후 SSCP방법으로 유전?? 형별 분석하였다. 결 과 : 대조군과 주요 우울장애 환자군 사이의 CTLA-4 유전자형과 대립유전자의 발현 빈도를 비교시 유의한 차이가 없었다. 결 론 : 본 연구 결과 exon 1 CTLA-4 유전자형 및 대립유전자의 발현빈도는 주요 우울장애 환자군과 정상 대조군 사이에 차이가 없어, exon 1 영역은 후보 유전자로서의 가능성이 없었다. 향후 연구에서는 다양한 변인들에 따라 대상군을 임상적으로 동질성을 지닌 집단으로 세분하여 조사대상 유전자와의 관련성에 대한 연구가 이루어져야 하겠다. Objectives : This study was carried out to explore the relationship between major depressive disorder and CTLA-4 which is related to the immunologic function such as T cell regulation. Methods : Among the korean patients diagnosed as major depressive disorder according to DSM-Ⅳ, 77 patients without neurological illness, hormonal disorder, or comorbid mental illness were selected. The stored data of 149 normal Koreans from the Catholic Hemopoietic Stem Cell Bank of Korea, were used as a normal control group. The data of Korean control group were compared with those of the studies of different ethnics. DNA was extracted from whole blood and the exon I region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed by using SSCP and then, the results were assessed. Results : There were no significant differences in genotype frquencies of CTLA-4*G/G, CTLA-4*G/A, and CTLA-4*A/A between the patients with major depressive disorder and the control group in Korean population(48.1% vs 46.3%, 41.6% vs 39.6%, 10.3% vs 14.1%, respectively).There were no significant differences in allelic frequencies of CTLA-4*G and CTLA-4*A between the patients with major depressive disorder and the control group in Korean population(68.8% vs 66.1%, 31.2% vs 33.9%, respectively). Conclusion : Considering negative result for the association of the exon I polymorphism of CTLA-4 gene with major depressive disorder in this study, the exon I polymorphism does not appear to be possible candidate gene for major depressive disorder. Moreover, further systematic researches including diverse clinical variables would required.

양극성 장애 1형에서 종양괴사인자 베타 유전자 다형성

전태연,이경욱,배치운,김원,우영섭,채정호,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : Bipolar disorder is known to have a high genetic predisposition. Recently, the main focus of etiologic studies in bipolar disorder has been concentrated on molecular genetic approach including gene polymorphism analysis. The present study was conducted to investigate whether TNFB polymorphism is associated with bipolar I disorder in the Korean population. Methods : 89 bipolar I disorder patients diagnosed by DSM-IV criteria were assigned as the patient group and 202 normal population, matched on age and sex from Catholic hemopoietic stem cell bank (Seoul, Korea), were enrolled as the control group in this study. Genotyping was performed by a polymerase chain reaction-restriction fragment length polymorphism method. All data was analyzed by x² test. Results : There were no significant differences in frequency of TNFB*1/1,TNFB*1/2 and TNFB*2/2 between bipolar I disorder patient group and normal control group. The frequency of TNFB*1 was not statistically different between bipolar I disorder patient group and normal control group. Conclusion : The difference of frequency in TNFB*1/TNFB*2 gene between the bipolar I disorder gropup and the normal contro1 could not be verified. The present result suggested that the gene polymorphism of TNFB may not play a significant role in susceptibility to bipolar I disorder. Studies with a larger number of subjects from different ethnic backgrounds, considring clinical phenotype and controlling various factors, should be launched to further determine the role of TNFB in bipolar I disorder.

진저섬망에 대하여

전태연 한국의학사 1987 診斷과治療 Vol.7 No.1

양극성 장애환자에서 HLA 대립형의 빈도와 질병연관성

전태연,Jun, Tae-Youn 대한생물정신의학회 1994 생물정신의학 Vol.1 No.1

For the purpose of evaluating the human leukocyte antigen(HLA) disease-association with bipolar disorder, HLA class I and class II allelic frequencies were assessed in 37 bipolar patients and were compared to the data from normal population. HLA class 1 typing was performed with microlymphocytotoxicity method while class II(DRB1) genotyping with reverse dot blot hybridization and sandwich method. Statistical analysis consisted of relative risk, Haldane's modified relative risk, Fisher's exact test and Bonferoni's corrected P. The results were as follows : 1) Bipolar patients showed increased allelic frequency of HLA A3 which has statistical significance. 2) Allelic frequencies of HLA B7, B14 and B54 were higher, while those of B51 and B55 were lower in bipolar patients, but they were not statistically significant. 3) Both of increased frequencies of DR2 in bipolar patients and DR15 in normal controls had statistical significance. The results of the present study suggested that some of HLA allelic types might be associated with bipolar disorder. To clarify the genetic influence of HLA to bipolar disorder, we should do consecutive study of bipolar disorder with new information about HLA system including alleles.

단순 및 연성전기충격요법에 의한 혈청 Cortisol5 Prolactin 및 성장 Hormone 값들의 변화

전태연,백인호 대한신경정신의학회 1982 신경정신의학 Vol.21 No.2

Recently it has been shown in numerous experimental studies that a series of electroconvulsive therapy (ECT) affects neurohormonal function in man, though the results of the studies have not yet confirmed the mechanisms of ECT. The authors measured serum cortisol, prolactin and growth hormone (GH) values before and after the induction of plain and softening ECT to trace if there is any significant quantitative change. The subjects consisted of 26 cases of plain ECT group and 9 cases o f softening ECT group. ECT was induced by the application of 110 volts for a period 0.3ᅳ2.0 sec., using bitemporal electrodes. Serum cortisol, prolactin and GH were measured by radioimmunoassay technique. The results were as follows; 1. It was revealed that cortisol value in the female group and the GH value in the male group increased significantly follow ing ECT, while prolactin value of both sex groups increased almost equally. 2. In plain ECT group, cortisol value and GH value increased significantly at 15,30,60 minutes follow ing the treatment. In the softening ECT group, significant increases were noted in the cortisol value at 15,30, 60 minutes follow ing the treatment and GH value at 15, 30,60 and 120 minutes following the treatment, while prolactin value increased without statistical significance. 3. It was considered that while the changes in the values of cortisol and of prolactin following ECT might be regarded as non-specific, the increase in the value of GH after ECT might have some specific meanings which may well require further verification.

정신분열병에서 Interleukin-10 유전자의 제한효소절편길이 다형성

전태연,배치운 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 중추신경계와 면역기능의 조절에 관여하는 싸이토카인 중 Interleukin-10 유전자다형성을 분석하여 정신분열병과의 면역·유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-IV에 의거하여 정신분열병으로 진단된 환자 114명을 선정하였으며 가톨릭조혈모세포정보은행에서 보유하고 있는 정상한국인 146명의 자료를 대조군으로 이용하였다. 전혈에서 DSP(direct sample preparation) 방법으로 DNA를 추출한 후 중합효소 연쇄반응(polymerase chain reaction)을 이용하여 IL-10유전자 부위를 증폭하였다. 이들 중폭산물을 제한 효소(MaeⅢ)로 분절 후 IL10*C와 IL10*T의 2가지 대립유전자에 대한 제한효소절편길이다형성을 조사하였다. 결 과 : 1) 정신분열병 군과 정상 대조군 간에 IL-10유전자형 IL-10*T/T, IL-10*T/C및 IL-10*C/C의 발현 빈도에서 유의한 차이가 없었다 (각 46.8%대 48.6%,44% 대 42.5%, 9.2% 대 8.9%). 2) 두 군간 IL-10*T와 IL-10*C 유전자 발현 빈도에는 유의한 차이가 없었다.(각 68.8%대 69.9%, 31.2% 대 30.1%). 결 론 : IL-10 유전자형 및 대립유전자의 발현빈도는 정신분열병 환자군과 정상 대조군 사이에 차이가 없었다. 향후 연구에서는 다양한 임상적 변인 등을 포함한 통합적인 조사가 이루어져야 하겠다. Objective : Recently, molecular genetic methods have been progressed, this study was to investigate the relationship between schizophrenia and immunologic aspects by analyzing polymorphism of IL-10 gene, which is involved in interaction of immunologic system and CNS. Method : 141 schizophrenic patients diagnosed by DSM-IV were included and data of 146 normal controls obtained from the Catholic Hemopoietic Stem Cell Information Bank of Korea were used in this study. DNA was extracted from whole blood, thereafter amplified by polymerase chain reaction, and digested by MaeⅢ After that procedure, we obtained and assessed RFLP of two alleles, IL-10T and IL-10C. All data were analyzed by x² test with two-tailed Fisher's exact test. Results : 1) There were no significant differences genotype frequencies of IL-10*T/T, IL-10*T/C, and IL-10*C/C in between schizophrenic patients group and control group. 2) There were no significant differences gene frequencies of IL-10*T and IL-10*C in between schizophrenic patients group and control group. Conclusion : We did not verified the frequency differences of IL-10*T/*IL-10*C gene between schizophrenic patients and normal controls, respectively. We do suggest that further systematic studies including various clinical variables should be conducted.

Prevalence of Unruptured Intracranial Aneurysm on MR Angiography

전태연,전평,김건하 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.5

Objective: To evaluate the prevalence of incidentally found unruptured intracranial aneurysms (UIAs) on the brain MR angiography (MRA) from a community-based general hospital. Materials and Methods: This was a prospectively collected retrospective study, carried out from January 2004 to December 2004. The subjects included 3049 persons from a community-based hospital in whom MRA was performed according to a standardized protocol in an outpatient setting. Age- and sex-specific prevalence of UIAs was calculated. The results by MRA were compared with intra-arterial digital subtraction angiography (DSA) findings. Results: Unruptured intracranial aneurysms were found in 137 (5%) of the 3049 patients (M:F = 43:94; mean age, 60.2years). The prevalence of UIAs was 5% (n = 94) in women and 4% (n = 43) in men, respectively (p = 0.2046) and showed no age-related increase. The most common site of aneurysm was at the distal internal carotid artery (n = 64, 39%),followed by the middle cerebral artery (n = 40, 24%). In total, 99% of aneurysms measured less than 12 mm, and 93% of aneurysms measured less than 7 mm. Direct comparisons between MRA and DSA were available in 70 patients with 83 UIAs;the results revealed two false positive and two false negative results. Conclusion: This community-hospital based study suggested a higher prevalence of UIAs observed by MRA than previously reported. These findings should be anticipated in the design and use of neuroimaging in clinical practice.

한국 자문조정 정신의학의 동향

전태연,방승규 최신의학사 1987 最新醫學 Vol.30 No.11