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흰쥐 두개골결손을 이용한 황산칼슘 및 탈회골 복합충진재의 골재생 촉진효과 연구
이은정 ( Eun Jung Lee ),전성현 ( Seong Hyun Jeon ),채지화 ( Ji Hwa Chae ),허재원 ( Jae Won Heo ),강계원 ( Ke Won Kang ),김진 ( Jin Kim ),김경표 ( Kyoung Pyo Kim ),이광원 ( Kwang Won Lee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Calcium sulfate is widely used for bone grafts as binder and expander. It was also reported that carboxymethylcellulose(CMC) can improve chemical characteristics for clinical applications when it is used as binder of calcium sulfate and demineralized bone matrix(DBM) for particulate bone grafts. DBM is an osteoinductive material which has been used to reconstruct bone tissue in maxillocraniofacial surgery, periodontics, and orthopedics. In this study, the effects of CMC-based putties containing DBM and/or calcium sulfate hemihydrate were evaluated in rat skull defects. Radiographs and histological evaluation of defect area after a period of time showed healing progress and new bone appeared greater for the treatment of CMC-based calcium sulfate hemihydrate putty compared to the untreated defect. When DBM was added to the putty, the most prominent bone regeneration effect was observed. We conclude that fast-resorbing CMC-based calcium sulfate hemihydrate putty containing DBM is effective for healing from the defective bone. CMC-based calcium sulfate may be used as a carrier and binder of bone graft materials for the restoration of bony defects.
연골 재생을 위한 젤라틴과 젤란검을 혼합한 하이드로젤 평가
송정은(Jeong Eun Song),송야성(Yah Seong Song),전성현(Sung Hyun Jeon),최일남(Il Nam Choi),김초민(Cho Min Kim),강길선(Gilson Khang) 한국고분자학회 2017 폴리머 Vol.41 No.4
천연 다당류인 젤란검은 내열성, 내산성, 내효소성이 우수하여, 널리 조직공학적으로 응용을 위해 사용된다. 그러나 젤란검은 낮은 세포 부착력을 갖는 단점이 있다. 따라서 본 연구에서는 연골 세포 부착 효율을 증진시키기위해, 젤란검 무게당 0, 10, 20 및 30 wt%의 젤라틴이 포함된 젤라틴/젤란검(G/GG) 하이드로젤을 제작하였다. 제작된 G/GG 하이드로젤의 물리적, 화학적 특성을 평가하기 위해, 압축강도, SEM, FTIR을 평가하였다. 또한 하이드로젤에서 연골 세포의 세포 부착력 및 기능적 유지를 관찰하기 위하여, MTT, RT-PCR을 수행하였다. 그 결과, 21일에 20 wt% G/GG 하이드로젤의 연골 세포 증식률은 0, 10, 및 30 wt%의 G/GG 하이드로젤보다 1.058, 1.051 및 1.04배 높게 나타났으며, 타입 2 콜라겐 유전자 발현 역시 각각 1.35, 1.21 및 1.16배로 관찰되었다. 그러므로, 20 wt% G/GG 하이드로젤은 연골 재생을 위한 생체재료로 활용할 수 있을 것으로 기대된다. Gellan gum is a natural polysaccharide with good heat, acid and enzymes resistance, and widely used for tissue engineering application. However, one of the drawbacks of gellan gum is lower cell attachment. Hence, in this study, gelatin/ gellan gum (G/GG) hydrogels containing 0, 10, 20, and 30 wt% of gelatin per gellan gum weight were prepared for improvement of chondrocyte attachment efficiency. The mechanical and chemical properties of prepared G/GG hydrogel were evaluated using compression strength, scanning electron microscopy and FTIR. Also, the cellular proliferation and functional maintenance of chondrocytes in hydrogel was assessed by MTT analysis, and RT-PCR. The results showed that 20 wt% G/GG hydrogel was 1.058, 1.051 and 1.04 folds higher chondrocyte proliferation compared to 0, 10 and 30 wt% and Type-II collagen gene expression was 1.35, 1.21 and 1.16 folds at 21 days, respectively. Thus, 20 wt% G/GG hydrogel can be envisioned as a useful biomaterial for future cartilage regeneration applications.