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고효율 항생제 감수성 검사를 위한 미세유체소자 내 선형적 항생제 농도구배 형성
김승규(Seunggyu Kim),이석훈(Seokhun Lee),전성윤(Jessie S. Jeon) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
To determine the most effective antimicrobial treatments of infectious pathogen, high-throughput antibiotic susceptibility test (AST) is critically required. However, the conventional AST requires at least 16 hours to reach the minimum observable population. Therefore, we developed a microfluidic system that allows maintenance of linear antibiotic concentration and measurement of local bacterial density. Based on the Stokes-Einstein equation, the flow rate in the microchannel was optimized so that linearization was achieved within 15 minutes, taking into account the diffusion coefficient of each antibiotic in the agar gel. As a result, the minimum inhibitory concentration (MIC) of each antibiotic against P. aeruginosa could be immediately determined 6 hours after treatment of the linear antibiotic concentration. In conclusion, our system proved the efficacy of a high-throughput AST platform through MIC comparison with Clinical and Laboratory Standards Institute (CLSI) range of antibiotics.
근세포의 물성 분석을 위한 in situ 테스팅 시스템 구축
김재상(Jaesang Kim),오인종(Injong Oh),Zhuo Feng Lee,심기동(Gi-Dong Sim),전성윤(Jessie S. Jeon) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
To develop an effective system for analyzing the mechanical property of cells, a silicon specimen that carries skeletal muscle cells is fabricated by MEMS process. Fabrication of micro-scale specimen includes backside photoresist patterning, reactive ion etching (RIE), and potassium hydroxide (KOH) etching. As-fabricated specimens provide opportunities for cell growth in a freestanding form. Afterward, by culturing skeletal muscle cells on the specimen, the biocompatibility of the specimen is verified. Ongoing measurements of the mechanical property of skeletal muscle cells using the developed testing system will also be presented.