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임신 전 체질량지수와 사산, 조산 및 저출생제중아 출산 위험
전병화,오희철,한영자,이상욱 한국모자보건학회 2012 한국모자보건학회지 Vol.16 No.1
Objective: To explore whether women with overweight or underweight before pregnancy would be at higher risk of adverse birth outcomes. Methods: A retrospective study was conducted on 41,975 mothers who received health examination in 1997, and delivered a singleton live baby in 1999 or a singleton stillbirth from 1999 to 2000. Odds ratio (OR) and 95% confidence interval (CI) for stillbirth, preterm birth, and low birth weight (LBW) according to pre-pregnancy body mass index (BMI, kg/m2) by 3 or 7 groups, were adjusted for maternal age at delivery, socio-economic status, diabetes and parity using logistic regression model. Results: The adjusted ORs for preterm birth and LBW were 1.39 (95% CI 1.09~1.79), and 1.38 (95% CI 1.05~1.81) in overweight (BMI≥25) women compared to normal weight women (BMI 18.5~24.9), and 2.37 (95% CI 1.60~3.52) and 1.56 (95% CI 0.94~2.59) in obese (BMI≥27.5) women compared to women with middle normal weight (BMI 21~ 22.9), respectively. Obese women had a increased risk on very LBW (OR 6.2, 95% CI 1.99~19.3) compared to middle normal weight women. Moderately to severely thin women (BMI<17) also had a increased risk on LBW (OR 1.65, 95% CI 1.21~2.24) and moderately LBW (OR 1.72, 95% CI 1.26~2.35) compared to middle normal weight women. Conclusion: Overweight, especially obese women were at higher risk on preterm birth including moderately preterm birth, and very LBW. Moderately thin women also had a increased risk on LBW including moderately LBW. It may be beneficial for women with overweight and moderate to severe thinness to have desirable birth outcomes by weight control such as physical activity and diet control.
고혈압백서 대동맥에서 Ca에 의한 수축에 미치는 Na/Ca교환기전의 영향
전병화,김국성,박경숙,김주석,김세훈,장석종 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
We investigated the contraction by sodium-calcium(Na-Ca) exchanges in the aortic strips of spontaneously hypertensive rats(SHR) and Wistar-Kyoto (WKY) rats. Resting tension of aortic strips in SHR was decreased by the removal of extracellular Ca and those were recovered by the addition of Ca. However, resting tone of aortic strips in WKY was not changed by Ca removal or Ca addition. Ca-induced contraction after exposure to Ca-free solution was suppressed by verapamil 10^-6M to 90% or more. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, the reduction of extracellular sodium concentration([Na]o) from normal(158 mM) to 0 mM(replaced by choline chloride) caused the contraction(Ca entry by Na-Ca exchange). The amplitude of contraction was more greater in SHR than in WKY rats. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, aortic strips were not contracted by Naand Ca-free solution, but was contracted by the addition of Ca. In the presence of verapamil 10^-5M and phentolamine 10^-6M and ouabain 10^-5M, Ca did not induce contraction after exposure to Ca-free Tyrode ' s solution, but in the presence of verapamil 10^-5M and phentolamine 10^-6M and monensin 10^-5M a sodium ionophore, Ca induced a little contraction in the aortic strips of SHR. These observations suggest that Na-Ca exchange does not contribute the development of Ca-induced contraction after exposure to Ca-free Tyrode ' s Solution in the presence of normal extracellular Na concentration. However, Na/Ca exchange in vascular smooth muscle is increased in SHR and may be involved in the mechanism for hypertension in SHR.
임신전 혈색소 농도가 사산, 조기출산, 저제중아출산에 미치는 영향
전병화,오희철,한영자,이상욱 한국모자보건학회 2009 한국모자보건학회지 Vol.13 No.1
Objective : To examine the influence of the maternal pre-pregnancy hemoglobin concentration on the perinatal outcome. Methods : Population based retrospective cohort study was conducted on 41,975 mothers who received health examination in 1997, and delivered a singleton live baby in 1999 or a singleton stillbirth in 1999. Rate and odds ratio of stillbirth, preterm birth, and low birthweight in accord with the level of pre-pregnancy hemoglobin level was examined. Results were adjusted for maternal age at delivery and pre-pregnancy body mass index using logistic regression model. Results : Adjusted odds ratio of stillbirth was found to be 4.25 times higher for mothers with less than 100 g/L hemoglobin concentration (95% CI, 1.82~9.92) and subsequently 1.79 times for those with 150 g/L or above (95% CI, 1.02~3.16) compared to those with 130~139 g/L. Adjusted odds ratio of preterm birth was higher among mothers with 100 g/L(Odds ratio: 2.10, 95% CI, 1.35~3.27) and 100~109 g/L (Odds ratio: 1.51, 95% CI, 1.10~2.07). Moreover, risk was not significantly elevated with mothers with high hemoglobin concentration. Adjusted odds ratio of low birthweight was 1.86 times, 1.48 times, and 1.07 times higher for the mothers with less than 100g/L (95% CI, 1.16~ 2.98), 100-109 g/L (95% CI, 1.07~2.05), and 150 g/L or above (95% CI, 0.82~ 1.39), respectively than for those with the 130~139 g/L pre-pregnancy hemoglobin level. Conclusion : A U-shape relationship between pre-pregnancy hemoglobin concentration and stillbirth was observed in this study. Low maternal pre-pregnancy hemoglobin concentration rather than high hemoglobin concentration increases the risk of preterm birth and low birthweight.
전치부 개방교합과 정상교합자의 근활성도에 관한 비교연구
전병화,김광원 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.1
This study was undertaken to compare the activity of masticatory muscle between normal occlusion and anterior openbite. 33 subjects without the experience of orthodontic treatment, missing teeth and the symptom of T. M. disorders were selected for this study : 25 subjects were normal occlusion and 8 subjects were anterior openbite. The ten items were measured from the cephalometric headplates, and EMG recordings of the anterior temporal and masseter muscle were taken at rest position and during maximum clenching at centric occlusion. All data were analyzed and processed with the computer statistical method. The following results were obtained : 1. At rest position, the muscle activities of both temporal and masseter muscle were higher in anterior openbite than in normal occlusion. 2. During maximum clenching, the muscle activities of both temporal and masseter muscle were prominently lower in anterior openbite than in normal occlusion. 3. At rest position, the temporal muscle of anterior openbite showed the highest activity, but showed the lowest muscle activity during maximum clenching. 4. Anterior openbite showed closer interrelationship between facial morphology and the muscle activity, and the muscle activity was more influenced by the form of mandible than that of maxilla.