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전병화(Jeon, Byeong-Hwa),김상섭(Kim, Sahng-Seop),김세훈(Kim, Se-Hoon),장석종(Chang, Seok-Jong) 대한생리학회 1990 대한생리학회지 Vol.24 No.2
The contractile action of barium (Ba<sup>2+</sup>) was investigated in the arterial strip of rabbit renal artery. The helical strip of isolated renal artery was immersed in the Tris-buffered Tyrode s solution equilibrated with 100% O<sup>2</sup> at 37℃ and its isometric tension was measured. Ba<sup>2+</sup>-induced contraction of arterial strip was dose-dependent and its maximal tension corresponded to 92.1±4.5% of tension by K<sup>+</sup>(100 mM). Ba<sup>2+</sup>-induced contraction did not show the tachyphylactic phenomenon in the normal Tyrode s solution. Ba<sup>+2</sup> induced the tonic contraction in the Ca<sup>2+</sup>-free tyrode s solution and that was increased by the extracellula addition of Ca<sup>2+</sup>. During the repeated exposure of the same dose of Ba<sup>2+</sup> (10 mM) in the Ca<sup>2+</sup>-free Tyrode s solution, Ba<sup>2+</sup>-induced contraction was progressively decreased. Even though the intracellular NE-and caffeine-sensitive Ca<sup>2+</sup> was depleted, Ba<sup>+2</sup> induced the tonic contraction. After the pretreatment of lanthnum or verapamil, Ba<sup>+2</sup> did not induce contraction. Ba<sup>2+</sup>-inducedcontraction was suppressed by extracellular K<sup>+</sup> in the normal Tyrode s solution and that was dependent on K<sup>+</sup> concentration. Suppressive effect of K<sup>+</sup> (14 mM) on the Ba<sup>2+</sup>-induced contraction was also dependent on the intracellular Ca<sup>2+</sup> concentration. From the above resuts, it is suggested that Ba<sup>+2</sup> activate indirectly the contractile process by promoting the mobilization of intracellular Ca<sup>2+</sup> and the influx of extracellular Ca<sup>2+</sup>. It is also suggested that action of Ba<sup>+2</sup> on the Ca<sup>2+</sup>-activated K<sup>+</sup> channel can result in the depolarization of cell membrane in the rabbit renal artery.
Amisulpride의 지속 투여가 생쥐의 성별에 따른 체중 및 대사에 미치는 영향
이효진,신윤오,전병화,박룡진,김정란,Lee, Hyo-Jin,Shin, Yun-O,Jeon, Byeong-Wha,Piao, LongZhen,Kim, Jeong-Lan 대한생물정신의학회 2008 생물정신의학 Vol.15 No.2
Objectives : This study was conducted to examine the effects on food intake, body weight, and metabolic parameters by amisulpride administration in male and female mice, comparing the effects of risperidone and vehicle administration. Methods : Female and male C57BL/6 mice were grouped into low dose amisulpride(1.5mg/kg), high dose amisulpride(15mg/kg), risperidone(0.1mg/kg) and vehicle. Drugs were administered once daily through intraperitoneal injection over 21days. Body weight was measured weekly and food intake was measured daily. Levels of triglyceride, glucose, insulin and prolactin were determined at the end of experiment(on day 22). Results : In the female mice, low and high dose amisulpride as well as risperidone caused significant weight gains. But weight gains in amisulpride groups were numerically smaller than that of risperidone group. In male mice, only high dose amisulpride caused significant weight gain. Among weight gain groups, only weight gain of male mice with high dose amisulpride was significantly associated with increased food intake. Weight gain group in female mice did not show significant correlation with food intake. In male mice, both amisulpride groups showed significantly high plasma insulin levels compared to vehicle. In female and male mice, low and high dose amiulpride groups showed significant high plasma prolactin levels compared to vehicle. Triglyceride level were not significantly changed in all groups. Glucose level was changed significantly only in male risperidone group. Conclusions : Administration of amisulpride caused more significant weight gains in female and male mice than controls but changes of metabolic parameters were different according to sex of mice. Our results suggest that different mechanisms of amisulpiride are likely to affect weight gain between male and female mice. 목 적 이 연구는 수컷과 암컷 생쥐에서 amisulpride를 투여하였을 때 먹이 섭취량, 체중 및 대사 지표에 대한 영향을 risperidone 및 정상 대조군과 비교하여 알아보고자 하였다. 방 법 수컷과 암컷 C57BL/6형 생쥐를 저용량 amisulpride 투여군(1.5mg/kg), 고용량 amisulpride투여군(15mg/kg), risperidone 투여군(0.1mg/kg)과 Vehicle군으로 나누었다. 약물은 21일간 매일 하루에 한 번 복강 주사를 통해 투여되었다. 체중은 일주일에 한 번씩 측정하였으며 먹이 섭취량은 매일 측정하였다. Triglyceride(TG), glucose, insulin 그리고 prolactin은 실험 종료 시에 측정하였다(실험 22일). 결 과 암컷 생쥐의 경우, 저용량과 고용량의 amisulpride 투여군에서는 유의한 체중 증가를 보였으며, risperidone 역시 유의한 체중 증가를 보였다. 그러나, 두 amisulpride군의 증가량은 risperidone군의 증가량에 비해 수치적으로 작았다. 수컷 생쥐의 경우, 고용량의 amisulpride만이 유의한 체중 증가를 가져왔다. 체중 증가를 보였던 집단 중에서, 고용량의 amisulpride를 투여하였던 수컷 생쥐만이 유의하게 증가된 먹이 섭취량과 연관성이 있었다. 암컷 생쥐에서 체중 증가를 보였던 군들은 먹이 섭취량과 유의한 상관성을 보이지 않았다. 수컷 생쥐에서, 두 개의 amisulpride 투여군 모두는 vehicle에 비해 유의하게 높은 혈장 insulin 수치를 보였다. 암컷과 수컷 생쥐에서, 저용량과 고용량의 amisulpride 투여군은 vehicle과 비교하여 유의하게 높은 혈장 prolactin수치를 보였다. Triglyceride는 모든 집단에서 유의하게 변화하지 않았으며 glucose는 수컷 risperidone 투여군에서만 유의하게 변화하였다. 결 론 Amisulpride는 암수 생쥐에서 체중 증가를 일으키지만, 대사 이상에 대한 결과는 성별에 따라 차이가 있었다. 본 연구의 결과는 amisulpride에 의한 체중 증가에 암수 생쥐에서 서로 다른 기전이 작용할 가능성을 시사한다.
수소이온농도 변화의 수축물질에 따른 가토신동맥 수축에 미치는 영향과 기전
장석종,김세훈,전병화,박해근,Chang, Seok-Jong,Kim, Se-Hoon,Jeon, Byeong-Hwa,Park, Hae-Kun 대한생리학회 1990 대한생리학회지 Vol.24 No.1
The effects of $H^{+}$ on the arterial contraction and their mechanisms were investigated in the renal artery of a rabbit. The helical strips of isolated renal artery were immersed in the HEPES-buffered or $CO_{2}/HCO_{3}^{-}$-buffered Tyrode's solution. The contractions induced by agonists (norepinephrine, histamine, serotonin and angiotensin II) or high $K^{+}$ were observed with change of extracellular or intracellular $H^{+}$ concentration. The contractions induced by norepinephrine, histamine, serotonin, angiotensin II or high $K^{+}$ in HEPES-buffered Tyrode's solution were inhibited by increase in extracellular $H^{+}$ concentration and potentiated by decrease in extracellular $H^{+}$ concentration. The degrees of these effects were most evident in the contraction induced by serotonin and angiotensin II, moderate in those by histamine and high $K^{+}$, and least in those by norepinephrine. Maximal contraction by norepinephrine, histamine and high $K^{+}$ were not influenced by change in extracellular $H^{+}$ concentration, but influenced in those contration by serotonin and angiotensin II. The attenuated contractions by an acidic pH were not returned to the level of contraction at normal pH (7.4) by elevation of extracellular $Ca{2+}$ concentration. The agonists (norepinephrine, histamine and serotonin)-induced contractions in $Ca{2+}$-free Tyrode's solution were also attenuated by increase in extracellular $H^{+}$ concentration and potentiated by decrease in extracellular $H^{+}$ concentration. Elevation of $Pco_{2}$ in the $CO_{2}/HCO_{3}^{-}$-buffered Tyrode's solution, which increase the intracellular $H^{+}$ concentration, at constant extracellular pH (7.4), increased the contraction by 30 mM $K^{+}$. From the above results, it is suggested that the decrease in contractions by increase in extracellular $H^{+}$ concentration may be resulted from that $H^{+}$ make the receptors less sensitive to agonists and cell membrane hyperpolarize and then inhibit the $Ca{2+}$ influx as well as $Ca{2+}$ release from intracellular $Ca{2+}$ storage site.
가토 신동맥 평활근에서 Strontium의 Calcium 대행역할
장윤철(Chang, Yun-Cheol),전병화(Jeon, Byeong-Hwa),장석종(Chang, Seok-Jong) 대한생리학회 1990 대한생리학회지 Vol.24 No.2
The Ca<sup>2+</sup>-substitutional$</TEX> roles of strontium for the contractile processes were investigated in the rabbit renal artery. The contractions induced by either norepinephrine or high K<sup>+</sup> in the condition which intra- and extracellular Ca<sup>2+</sup> were replaced by Sr<sup>2+</sup>, i.e. Sr<sup>2+</sup>-mediated contractions, were dose-dependent. And then the maximal amplitude of contraction, as compared with Ca<sup>2+</sup>-mediated contraction, was about 50% in norepinephrine and about 70% in high K<sup>+</sup>. The Sr<sup>2+</sup>-mediated contractions were independent in the contraction by norepinephrine 10<sup>-5</sup>M) but dependent in those by high K<sup>+</sup>(100 mM) on the extracellular Sr<sup>2+</sup> concentration. Also Sr<sup>2+</sup>-mediated contractions induced by norepinephrine were observed in the Sr<sup>2+</sup>-free Tyrode s solution. The Sr<sup>2+</sup>-mediated contractions induced by either norepinephrine or high K<sup>+</sup> were suppressed by verapamil, a Ca<sup>2+</sup>-channel blocker. By extracellular addition of Sr<sup>2+</sup>, the Ca<sup>2+</sup>-mediated contractions induced by norepinephrine 10<sup>-5</sup>M) or 40 mM K<sup>+</sup> were inhibited but those by high K<sup>+</sup>(100 mM) were increased. And the Sr<sup>2+</sup>-mediated contractions were increased by extracellular addition of Ca<sup>2+</sup> but did not reach the level of Ca<sup>2+</sup>-mediated contraction. Therfore it is suggested that in the vascular smooth muscle of rabbit renal artery Sr<sup>2+</sup> could enter the smooth muscle cells easily through the potential-operated calcium channel (POC) but not easily through the receptor-operated calcium channel (ROG), and Sr<sup>2+</sup> might be stored in the intracellular Ca<sup>2+</sup>-binding site and released by NE and induced the contraction by a way of activating directly the contractile apparatus.