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다배란과 수정란이식 및 체외수정기술을 이용한 소의 유전적 개량량 비교
전광주 韓國受精卵移植學會 1996 한국동물생명공학회지 Vol.11 No.1
다배란 수정란이식(MOET)과 체외수정(IVF)기술을 이용한 육종체계에서 예상되는 유전적 개량량을 여러 집단의 크기에서 비교한 결과 체외수정기술이 MOET육종기술보다 특히 개량대상 유전력이 낮을때 훨씬 효율적으로 나타났다. 그러나 유전력이 높아지면 (h=0.3, 0.5), MOET와 IVF간의 상대적 차이는 미진하게 나타났다. 체외수정을 이용한 육종기술에서 암컷의 선발 강도는 대단히 높일 수 있는 반면 난자의 회수율이 많을수록 상대적으로 수컷에 대한 선
전광주 韓國受精卵移植學會 1995 한국동물생명공학회지 Vol.10 No.1
Genetic changes from improving female's reproductive rate through in vitro fertilization of large number of oocytes were studied. The breeding scheme employed was multiple ovulation and embryo transfer of juveniles and adults. Both balanced and unbalanced matings were examined for the four closed progeny population sizes, 10, 10, 105, 106. In balanced matings, all selected sires and dams were mated to each other(cross-classified mating) while unbalanced matings allowed selected dams and sires mated partially, eg. unbalanced matings allowed averages of .5 and .25 progeny per each mating. Various numbers of selected sires and dams were also examined in both balanced and unbalanced matings. In all mating schemes, selection of males and females was restricted to he one from each fullsib family to reduce the rate of inbreeding. The model calculations were deterministic and accounted for the effects of selection and inbreeding on loss of the genetic variation in succeeding generations. Balanced rectangular mating schemes, where more donors were selected than sires, resulted in larger selection responses than balanced square mating schemes, where equal numbers of sires and donors were selected, and unbalanced rectangular mating. The first round selection responses from the balanced rectangular matings of juvenile MOET, eg. number of progeny per mating equals 2 with 10 sires selected, were 1.192, 1.406, 1.580 and 1.735 times larger than the first round selection responses from the balanced square mating schemes for the given four progeny population sizes, 10, 10, 105 and 106, respectively. Similar results were obtained in adult MOET breeding schemes. However, balanced square matings gave greater selection responses than the unbalanced rectangular matings.
회귀식을 이용한 양적형질유전자좌의 지도작성과 효과추정에 관한 시뮬레이션 연구
전광주,공홍식 한국동물자원과학회 2000 한국축산학회지 Vol.42 No.4
A simulation study was used to estimate the effect of quantitative trait loci(QTL) and its location using flanking markers by regression method. Various parameter combinations such as heritability(0.05, 0.10, 0.30), map distance between markers were used to find the relative effects of these parameters on the estimation of the parameters using regression method. The true effect of QTL additive effect was assumed 0.3 phenotypic standard deviation. The relative size of map distance between flanking markers(10cM, 20cM, 40cM), assuming the QTL being located on the middle, was found no significant effect on the estimates of true map distance. And also, the various sample size per marker genotype(50, 100, 200) was not a significant factor on the parameter estimates. The main criteria for the estimation of the QTL effects and QTL location were the minimum mean square error from the regression model by iterating the map distance from 0cM to 50cM with a small size of interval(0.05 cM). The distribution of estimated error mean squares by the regression model by iterating the map distance from 0cM to 50cM with an interval of 0.05cM followed a smooth quadratic form. In all cases, the estimated QTL location was found exactly coincided with the true QTL location and the estimated additive genetic effect of QTL was quite accurate.
Gene Flow 방법을 이용한 점근선적 선발반응 추정
전광주 ( G . J . Jeon ) 한국축산학회 1992 한국축산학회지 Vol.34 No.4
The use of the gene flow method was illustrated using a simple numerical example in this work. The main advantage of the gene flow method is an ability to monitor the entire trend of genetic progress during a given time horizon for a breeding scheme. The use of gene flow model is useful and effective for the estimation of selection response especially when a time horizon of a breeding plan is short. And the gene flow model also can be easily extended to any general breding population of all livestock species.