MIM에 의한 WC-12%Co 초경합금의 제조

장홍선,이완재,김경배,김찬영 한국분말야금학회 1999 한국분말야금학회 학술대회논문집 Vol.1999 No.1

Concurrence of segmental vitiligo and facial palsy associated with acoustic schwannoma

장홍선,이정수,김미리,오상호 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

The role of metal allergen in the intrinsic atopic dermatitis

장홍선,노성민,배병기,박창욱,이광훈 대한피부과학회 2011 초록집 Vol.49 No.20

Unusual Manifestation of Molluscum Contagiosum: Eruptive Papules on the Face and Neck of an Immunocompetent Patient

장홍선,오상호 대한피부과학회 2013 Annals of Dermatology Vol.25 No.3

없음

비전문적 피부미용시술로 인한 합병증과 치료 방법의 고찰

장홍선 ( Hong Sun Jang ),정기양 ( Kee Yang Chung ),오병호 ( Byung Ho Oh ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4

Background: As the desire to maintain a youthful appearance escalates nationwide, the numbers of patients presentingwith complications subsequent to cosmetic treatments performed by non-professionals are increasing. Objective: The purpose of this study was to overview complications from cosmetic therapeutic attempts by nonprofessionals,and to discuss their management from a dermatologist’s point of view. Methods: During the period January 1st, 2011 to December 31st, 2013, a total of 24 patients who visited the SeveranceHospital at Yonsei University for complications that developed after cosmetic treatments by oriental doctors,non-medical personnel, and general practitioners were enrolled in this study. Patient clinical characteristics, pasthistory, diagnosis, biopsy results, and treatment information were collected. Results: The most common complication was a granulomatous foreign body reaction (n=15, 62.5%), followed byskin necrosis (n=8, 33.3%), and misdiagnosis and malpractice by non-professionals (n=5, 20.8%). Three patients hadmore than 2 complications combined. Patients with granulomatous foreign body reactions were usually managed withconservative treatments or excisions, while those with skin necrosis were managed with debridement and secondaryintention healing. Conclusion: As the number of cosmetic therapeutic attempts made by non-professionals increases, dermatologistsneed to understand the potential complications that can arise following these procedures, and should take an activerole in managing the patients.

WC - Ni3Al 초경합금의 미세조직

이종일,장홍선,이완재 대한금속재료학회 1993 대한금속재료학회 학술대회 개요집 Vol.1993 No.0

Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions

이의형,김지은,장홍선,박규현,오병호,신상준,정기양,노미령,라선영 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between primary and metastatic melanoma in Korean melanoma patients, we evaluated several well-known genetic alterations of melanoma. In addition, to elucidate the clinical relevance of each genetic alteration and heterogeneity between primary and metastatic lesions, clinical features and patient outcome were collected. Materials and Methods In addition to clinical data, BRAF, NRAS, GNAQ/11mutation and KIT amplification data was acquired from an archived primary Korean melanoma cohort (KMC) of 188 patients. Among these patients, 43 patients were included for investigation of tumor heterogeneity between primary melanoma and its corresponding metastatic lesions. Results Overall incidence of genetic aberrations of the primary melanomas in KMC was 17.6% of BRAF V600, 12.6% of NRASmutation, and 28.6% of KIT amplification. GNAQ/11mutation was seen in 66.6% of the uveal melanoma patients. Patients with BRAF mutation were associated with advanced stage and correlated to poor prognosis (p < 0.01). Among 43 patients, 55.8% showed heterogeneity between primary and metastatic lesion. The frequency of BRAF mutation and KIT amplification significantly increased in the metastatic lesions compared to primary melanomas. GNAQ/11mutation showed 100% homogeneity in uveal melanoma patients. Conclusion Our data demonstrated heterogeneity between primary melanomas and corresponding metastatic lesions for BRAF, NRAS mutation and KIT amplification. However, GNAQ/11 mutation was genetically homogeneous between primary and metastatic melanoma lesions in uveal melanoma.

춘천 중도 유적에서 출토된 원삼국시대 토기 탄착물에 대한 화학적 분석

강소영,지상현,김윤지,장홍선 한국문화재보존과학회 2013 보존과학회지 Vol.29 No.4

춘천 중도 유적에서 출토된 원삼국시대 경질무문토기 내부의 탄화된 물질에 대한 화학적 분석을 실시하였다. 가스크로마토그래피-질량분석과 퓨리에변환적외선분광분석을 이용하여 부착물에서 유래한 유기물의 정성분석을 수행한 결과, 지방산, 스테롤 등 지방 성분이 검출되지 않았다. 탄소와 질소 안정동위원소 분석 결과 부착물을 구성하고 있는 탄소 안정동위원소 비는 평균 -14.7±2.8‰ (-8.7‰~-18.4‰, n=9), 질소 안정동위원소 비는 평균 6.2±1.1‰(-4.4‰~-7.6‰, n=9)로 나타났는데 이 결과는 부착물이 조리된 음식물에서 유래되었음을 추정할 수 있는 과학적 근거라고 할 수 있다. 본 연구결과는 안정동위원소 분석을 조리용 토기 내 탄화된 잔존물 분석에 적용한 국내 첫 사례로서 당시의 토기 용도와 식생활 습관에 대한 중요한 정보를 제공할 것으로 기대된다.

부뚜막취사의 실험고고학적 검토

오승환,장전신시(庄田愼矢),정종태,장홍선,정수옥,한지선,허진아 한국고고학회 2008 한국고고학전국대회 발표문 Vol.- No.32

삼국시대의 취사형태 복원을 위한 기초연구 - 시루와 장란형토기를 이용한 취사실험

오승환,정종태,한지선,정수옥,장홍선,허진아 한국문화유산협회 2009 야외고고학 Vol.0 No.6

식문화탐구회에서는 지난 2008년 부뚜막에 장란형토기를 걸어 삼국시대의 취사 형태를 복원하기 위한 실험을 실시한 바 있다. 실험 결과 밥은 완성되었지만, 고고자료와의 비교를 통해 장란형토기는 주로 물을 끓이는 용도였음을 알게 되었다. 이에 이번 2009년에는 장란형토기와 시루를 결합한 형태를 대상으로 실험을 실시하여 삼국시대의 취사형태를 복원해보고자 하였다. 실험을 위해 2008년에 제작된 부뚜막을 보수하고 시루와 장란형토기를 지역적 특징에 따라 서울경기권과 호서호남권으로 나누어 제작하였다. 곡물은 삼국시대의 유적에서 주로 확인되는 쌀(현미), 콩, 팥, 조를 일정 비율로 섞어 사용하였다. 실험은 동일한 조건으로 6차례에 걸쳐 진행하였으며, 다채널 온도측정기를 사용하여 시간대별 시루와 장란형토기 내·외면 온도변화, 시루 내 곡물의 온도변화를 측정하였고, 곡물과 수분의 증감 등을 관찰하였다. 그리고 실험이 종료되면 밥의 완성도와 함께 시루와 장란형토기의 내·외면을 실측하여 취사흔적을 살펴보았다. 처음 4차례의 실험에서는 밥이 설익거나 수분이 부족하고 찰기가 없어, 일상적인 밥의 형태가 되지 않았다. 이에 최근까지도 이어져오는 전통적인 방법인 수분보충방식에 착안하여, 마지막 2차례의 실험에서는 밥을 짓는 도중 시루 안에 정기적으로 물을 뿌려주었다. 그 결과, 완성된 밥에서 찰기와 수분이 어느 정도 유지되었다. 하지만 이러한 수분보충 방식은 하나의 형태에 불과할 뿐 보편적인 일상 취사방식으로 판단하기는 어렵기 때문에 또 다른 취사방식에 대해서도 검토할 필요가 있다. 그리고 밥을 짓는 횟수가 늘면서 점차 완성도가 높아지므로, 실험자의 숙련도 역시 밥 짓기에 있어서 매우 중요한 요소임을 알게 되었다. 아울러 취사형태를 이해하기 위해서는 여러 변수에 대비할만한 더 많은 실험과 분석이 필요함을 절감하였다. 이번 실험을 통해 삼국시대 취사형태에 대한 명쾌한 결론은 제시되지 못했더라도 이를 바탕으로 한국고대의 취사 및 음식문화 연구가 한걸음 더 나아가는 계기가 되었다고 생각한다. This research clarifies that the siru (steam pot) may have been used for making rice in the Three Kingdoms Period. The reason for this experiment was because last year we concluded that the egg-shaped pot (長��Ñ��Ñ形土器) was used only for boiling water. Therefore, the experiment aims to prove that the siru, instead of the egg-shaped pot, was used to make rice in the Three Kingdoms period. The experiment was conducted on the cooking stove used last year, and the siru and egg-shaped pots were each divided into those of the Seoul-Gyeonggi region and Hoseo-Honam region. The experiment was conducted six times using rice, millet, beans, and red-beans, which are mainly found at sites of the Three Kingdoms period. Up to the fourth experiment, the rice was half-cooked due to lack of moisture. However, during the last two experiments, the lid of the siru was opened and the rice was watered during cooking. As a result, we succeeded in making rice. The method of adding moisture, however, merely made it possible to make rice in another way and cannot be considered as a definite method of rice making. Accordingly, the method of adding moisture should be examined further. Meanwhile, it may be possible that charcoal was used for rice making in the Hoseo-Honam region. This is because the bottom of egg-shaped pots appear to have been heated with charcoal, rather than firewood. In addition, the cooking stove of the Hoseo-Honam region is too small to have burned firewood. Just like last year, this experiment proves that the quality of rice making increases with the number of attempts. We thus concluded that people in the Three Kingdoms period used the cooking stove and siru for rice making. It also became clear that more experiments and analyses are needed for discovering various cooking methods. This experiment is merely a beginning because we cannot present more evidence compared to that of archaeological features and pottery.