대장 및 직장암 289예에 대한 임상적 고찰 -5년 생존율에 영향을 미치는 요소-

장문영,김종훈,유희철,박철웅,황용 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.4

체위보완간호가 수술 후 체위와 관련된 통증에 미치는 영향 : 유양 돌기 절제술 환자를 중심으로

장문영,이윤아,정수경,민경양,김정은,김계숙,최옥진,임유경 병원간호사회 2000 임상간호연구 Vol.6 No.1

The pain after surgery, one of main complaints of patients, is directly related to how much nerve at tissue has been hurt on surgical area. However, the pain not on the surgical area is related to the inappropriate performance of different surgical positions during surgeries. This kind of pain of patient after a long surgery can be prevented so suitable positional care is essential. This research will show you how suitable positional care using cotton pad and VAC-PAC^(®) is effective to reduce the pain occurred from an inappropriate surgical position after a long surgery. We picked 40 adult patients who had mastoidectomy as volunteers at a general hospital in Seoul and divided them 4 groups with 10 members. All information had been gathered from the 19th of May, 1999 to the 26th of August, 1999. Cotton pad and VAC-PAC^(®) were used to group Ⅰ and group Ⅱ, respectively. First information was gathered from patients at recovery room and then 5 O/R nurses had visited them to measure the degree of pain relating to surgical position with using information-gathering tools for 4 days after surgery. The result of this research following the above steps will be as fallow 1. The difference of the age, sex, height and weight of patients, anesthetic time, surgical time, surgeon and so on could not significantly affect the research result among groups(p<.05). 2. There was big difference among groups at how much patients felt shoulder pain at the 2nd day after surgery(p<.05). Patients at group Ⅱ felt smallest pain and patients who were not taken care of by suitable positional care felt biggest pain among groups. 3. There was important difference among groups at the degree of pain not on surgical area at 3rd day after surgery (p<.05). The degree of the pain of group Ⅱ was the lowest among groups. 4. There was a big difference between group Ⅰ and group Ⅱ at the degree of the pain at 3rd day after surgery. However, there was a little difference between two groups at the other factors as time went. We couldn't control the amount of analgegics to reduce pain from 1st to 3rd day after surgery and couldn't control the error come from 5 different information collectors. Despite of this kind of limitation, we can partially support the two assumptions: Assumption Ⅰ. The degree of the pain of group Ⅰ and Ⅱ that received suitable positional care should be lower than that of the other groups. Assumption Ⅱ. The degree of pain of group Ⅱ using VAC-PAC^(®) is lower than that of group Ⅰ using cotton pad. The pain not on the surgical area occurring from an inappropriate surgical position during a long surgery can be prevented so we can conclude that suitable positional care is essential.

초발 정신증 환자에서 Mismatch Negativity를 이용한 1년 간의 예후 예측 연구

장문영,김민아,이탁형,권준수 대한조현병학회 2017 대한조현병학회지 Vol.20 No.1

Objectives : It has been shown that early intervention is crucial for favorable outcome in patients with schizophrenia. However, development of biomarkers for predicting prognosis of psychotic disorder still requires more research. In this study, we aimed to investigate whether baseline mismatch negativity (MMN) predict prognosis in patients with first episode psychosis (FEP). Methods : Twenty-four patients with FEP and matched healthy controls (HCs) were examined with MMN at baseline, and their clinical status were re-assessed after 1 year. Repeated-measures analysis of variance was performed to compare baseline MMN between the two groups. Multiple regression analysis was used to identify factors predicting prognosis in FEP patients during the follow-up period. Results : MMN amplitudes at baseline were significantly reduced in patients with FEP compared to healthy controls. In the multiple regression analysis, baseline MMN amplitude significantly predicted later improvement of performances on digit span and delayed recall of California Verbal Learning Test. However, baseline MMN did not predicted improvement of clinical symptoms. Conclusion : These results indicate that MMN may be a possible predictor of improvement in cognitive functioning in patients with FEP. Future study with larger sample and longer follow-up period would be needed to confirm the findings of the current study.

Strategy for the Customized Mass Screening of Genetic Sensorineural Hearing Loss in Koreans

장문영,최병윤 대한청각학회 2014 Journal of Audiology & Otology Vol.18 No.2

Hearing loss is one of the most common sensorineural disorder. More than half of congenital bilateral profound deafness cases have been estimated to be attributed to genetic cause. Identification of genetic cause can provide valuable information. We developed new diagnostic strategy combining phenotype-driven candidate gene approach and targeted exome sequencing to find out the causative mutation of hearing loss. The causative mutation detection rates of this strategy were 78.1% and 54.8% in Korean multiplex families and sporadic severe to profound hearing loss families, respectively. The most frequent causative genes of Korean multiplex families were SLC26A4 and POU3F4. The other causative genes were MRNR1, WFS1, COCH, TECTA, MYO6, COL11A2, EYA4, GJB3, OTOF, STRC, MYO3A, and GJB2. The most frequent causative gene of Korean sporadic severe to profound hearing loss families was SLC26A4 followed by GJB2, CHD7, and CDH23. Based upon the results, the value of this strategy as a diagnostic tool seems to be promising. Although whole genome and exome sequencing have advanced as the development of next-generation sequencing, this new strategy could be a good screening and diagnostic tool to find the causative mutations.

(1) 늑막염, (2) 맹장염, (3) 쓰림 험방

장문영,Jang, Mun-Yeong 대한한약협회 1998 大韓漢藥 Vol.2 No.-

신체장애인들의 보조기기 사용이 일상생활활동 수행 능력과 삶의 만족도에 미치는 영향

장문영,황기철,안덕현 대한작업치료학회 2005 대한작업치료학회지 Vol.13 No.2

목적 : 본 연구는 신체장애인들이 사용하는 보조기기가 일상생활활동 수행 능력과 삶의 만족도에 미치는 영향을 알아보기 위한 것이다. 연구방법 : 본 연구는 경상남도 김해시에 거주하는 신체장애인 40명을 대상으로 2004년 8월 1일부터 동년 8월 31일까지 각 가정을 방문하여 일상생활활동 능력 평가 및 설문조사를 실시하였다. 자료 수집을 위해 사전 지도와 FIM 평가에 대한 훈련을 받은 6명의 연구원들이 장애인과 개별적 면접을 통해 시행하였다. 설문지는 장애인의 일반적인 특성 9문항과 보조기기관련 7문항, 5점 척도의 재활의료서비스, 가족 지지정도, 지역사회참여 정도에 대한 만족도 항목 3문항으로 구성되었다. 결과 : 보조기기 사용 유무에 따른 신체장애인의 일상생활활동 수행 능력은 차이가 없었다. 재활의료서비스 만족도는 보조기기 사용집단과 미사용집단 간에는 통계학적으로 유의한 차이가 없었다. 가족지지 만족도와 지역사회참여 만족도는 보조기기 미사용집단보다 사용집단에서 모두 높은 만족도를 보였다(p<0.05). 결론 : 신체장애인들이 보조기기를 사용한 경우 가족지지와 지역사회참여 만족도에서 보다 높은 만족도를 보였다(p<0.05). 보조기기 사용유무에 따른 일상생활활동 수행 능력과 재활의료서비스 만족도에서는 통계학적으로 유의한 차이가 나타나지 않았다. 앞으로의 연구에서는 지역별 특성을 고려하여 여러 지역의 많은 장애인을 대상으로 보조기기 사용 특성에 대한 연구가 이루어져야 할 것이다. Objective : The purpose of this study is to determine the impact of assistive device on the perform in ADL and life satisfaction. Methods : From August 1 through August 31 in 2004, the researchers visited forty physical disability people who reside in Gyeong-nam Gimhae-si to evaluate ADL using survey. The six researchers, who already finished all of FIM(functional independence measure) evaluation, individually interviewed the subject. The survey consists of 9 general character questions, 7 assistive device questions, and 3 satisfaction of life questions. Especially, the satisfaction of life questions based on 5 point scales by rehabilitation medical service, family support level, and participation level in the country. Results : Whether the subjects use assistive device or not, there was no difference to the subject's ADL skills. According to the subject who do not use the assistive device, there were statistically no difference at all in their satisfaction of rehabilitation medical service. However, according to the subject who use an assistive device with family support and participation in the country, they all showed high satisfaction (p<0.05). Conclusion : When the people with physical disabilities use the assistive device, family support and participation in the country highly effected in their satisfaction (p<0.05). Therefore, future study should investigate more people with physical disabilities who use an assistive device by considering regional characteristic.

작업치료 중재가 노인의 복지용구급여 서비스 만족도에 미치는 영향

장문영,정혜영 대한작업치료학회 2010 대한작업치료학회지 Vol.18 No.4

목적 : 노인장기요양보험 중 복지용구급여 서비스 과정에서 작업치료 중재 유무에 따른 대상자의 만족도를 비교, 분석하여 복지용구급여 서비스 체계 내에서 작업치료사의 전문적 역할을 모색하고자 한다. 연구방법 : 본 연구는 복지용구급여 서비스 과정에서 작업치료 중재를 받은 5명과 작업치료 중재를 받지 않은 5명을 대상으로 복지용구급여 서비스 만족도를 측정하였다. 자료 수집은 작업치료사가 면담을 통하여 실시하였으며, 자료 수집기간은 2009년 9월부터 12월까지였다. 대상자의 만족도 측정을 위해 Quebec User Evaluation of Satisfaction With Assistive Technology(QUEST) 2.0을 사용하였고, 대상자의 기능을 평가하기 위해 International Classification of Functioning, Disability and Health (ICF) 체크리스트를 사용하였다. 결과 : 작업치료 중재 집단이 작업치료 비중재 집단 보다 더 높은 만족도를 보였으며, 복지용구 기기에 대한 항목 중 효과성은 통계학적으로 유의한 결과를 보였다(p=.01). 복지용구 서비스에 대한 항목에서는‘수리와 유지관리 서비스’항목(p=.02)과‘전문가 서비스의 질’항목(p=.01)이 통계학적으로 유의한 결과를 보였다. 결론 : 본 연구를 통해 복지용구급여 서비스에서 작업치료 중재가 대상자의 만족도를 향상시킬 수 있음을 확인하였 다. 본 연구 결과는 복지용구급여 서비스 전문가로서 작업치료사의 필요성에 대한 근거를 제시할 수 있다. 또한 본 연구를 기초로 복지용구급여 서비스 전문가로서 작업치료사의 역할에 대한 체계를 구성할 수 있을 것이다.

Comparison of Free-Beam- and Fiber-Type CO2 Laser Delivery Systems in Stapes Surgery

장문영,최현석,이상엽,구자원 대한청각학회 2017 Journal of Audiology & Otology Vol.21 No.2

Background and Objectives: A free-beam-type CO2 laser, which use a micromanipulatormounted on a microscope as the delivery system, has the merit of not being affected byhand tremor at the time of shooting. However, this delivery system has several disadvantages,including a restricted operation range and a risk of incorrect focusing. A fiber-type CO2 laseruses a hand-held delivery system and has the opposite merits and demerits. We comparedthe results of stapes surgery with free-beam and fiber type delivery systems. Subjectsand Methods: The study enrolled 36 patients who underwent stapedotomy with free-beam-(n=26) or fiber- (n=10) type CO2 lasers. The air-bone (AB) gap closure, bone conduction (BC)change, and operating time were evaluated. The AB gap closure was calculated by subtractingthe preoperative BC thresholds from the postoperative air conduction thresholds. The BC change was calculated by subtracting the postoperative BC thresholds from thepreoperative BC thresholds. Results: The mean operating time was significantly (p=0.035)shorter in the fiber-type group (72.5±8.2 min) than in the free-beam-type group (80.5±11.4min). The mean AB gap closure did not differ significantly (p=0.297) between the free-beamandfiber-type groups (5.8±10.1 and 1.4±6.8 dB, respectively). The mean BC change didnot differ significantly (p=0.873) between the free-beam- and fiber-type groups (2.4±6.9 and2.8±5.3 dB, respectively). The hearing outcomes did not differ significantly between the twogroups. Conclusions: Operating times were significantly shorter using the fiber-type CO2 laser,while hearing outcomes did not differ significantly between the two groups.

The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1

장문영,이지혜,김신혜,김영호 대한이비인후과학회 2018 Clinical and Experimental Otorhinolaryngology Vol.11 No.1

Objectives. Local administration of 3-nitropropionic acid (3-NP) to the inner ear induces sensorineural hearing loss. Several studies have shown the otoprotective effects of ginkgo biloba extract EGb 761. Moreover, EGb 761 has been reported to activate Sirtuin 1 (SIRT1). The present study was designed to investigate whether EGb 761 prevents 3-NP-induced sensorineural hearing loss and determine its effects on the expression of SIRT1. Methods. Sprague Dawley rats were divided into four experimental groups: control group receiving vehicle of 3-NP, EGb group receiving EGb 761, 3-NP group receiving 3-NP, and EGb+3-NP group receiving EGb 761 and 3-NP. EGb 761 was given orally for 5 days. The 3-NP solution was injected into the tympanum 3 days after the start of EGb 761 administration. The auditory brainstem response was recorded before and after the injection. At 4 weeks after the administration of 3-NP or vehicle of 3-NP, cochleae were harvested, and hematoxylin and eosin staining and immunohistochemistry for SIRT1 antibody were performed. Results: EGb+3-NP group showed significantly lower threshold shifts than 3-NP group. There was a significant preservation of type II fibrocytes and spiral ganglion cells in EGb+3-NP group than in 3-NP group. In EGb+3-NP group, there was a significantly greater number of SIRT1 immunopositive type II fibrocytes and spiral ganglion cells than in 3-NP group. Calculating the percentage of SIRT1 immunoreactive type II fibrocytes and spiral ganglion cells in viable type II fibrocytes and spiral ganglion cells, respectively, EGb+3-NP group showed significantly higher SIRT1 immunoreactive cells than 3-NP group. Conclusion. These results suggest that EGb 761 may prevent hearing loss induced by 3-NP in an acute ototoxic animal model, which appears to be related with SIRT1 expression.

체위보완간호가 수술 후 체외와 관련된 통증에 미치는 영향 -유양 돌기 절제술 환자를 중심으로

장문영,이윤아,정수경,민경양,김정은,김계숙,최옥진,임유경 병원간호사회 2000 임상간호연구 Vol.6 No.1