소아의 골밀도에 관한 연구

장규태,김장현,서영민,Chang, Gyu-Tae,Kim, Jang-Hyun,Seo, Young-Min 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.1

Objectives : Osteoporosis is generally occurred in old age, especially postmenopausal women therefore, it is relatively overlook osteoporosis in children, but the authors have paid attention to bone density in children because maximizing peak bone mass of childhood is advocated as a way to prevent osteoporosis and environmental factor of childhood play role in the regulation of bone density. the present study was performed to measure bone density of children and to assess the influence of age, sex, body size, exercise, weak symptoms on bone density during the period of bone growth. Methods : We have measured bone density of calcaneus bone in 283 children (male 144 female 139, ranged from3 to 18) who visited in growth clinic of Pediatrics, Dongguk University Bundang Oriental Hospital, using quantitative ultra sound densitometry and they were divided into 3 groups by age(3-10, 11-15, 15-18 years). Pearson's correlation was used to assessed the influence of age, body size and Student's t-test was used to detect differences in sex, exercise, weak symptoms between the groups on bone density Results : The bone density correlated with age, height, weight, body mass index in this study. Bone density were significantly higher in males than in female. Digestive weak children's bone density were lower than normal children. Conclusion : Weight-bearing exercise and food rich in nutrition are necessary to increase maximizing peak bone mass in children.

황금(黃芩)이 니코틴 중독에 미치는 효과

장규태,김장현,서영민,Chang, Gyu-Tae,Kim, Jang-Hyun,Seo, Young-Min 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.1

Objective : The purpose of this study is to investigate the effect of Radix Scutellariae on repeated nicotine-induced locomotor activity and c-Fos expression utilizing Fos-like immuno-histochemistry method in the nucleus accumbens, and the striatum, one of the major projection areas of the control DA system. Methods : Male Sprague-Dawley rats were divided into untreated(normal), nicotine-treated (control), Radix Scutellariae-treated(sample) groups, RS group received Radix Scutellariae(100mg/kg, i.p.) 30minutes before injection of nicotine(0.4mg/kg, s.c.) for 7days. Rat were followed withdrawal for 3 days and one challenge for 1day. Results : Systemic challenge with nicotine produced a much larger locomotor activity and expression of c-Fos in the nucleus accumbens and the striatum. Pretreatment with Radix Scutellariae decreased in nicotine-induced locomotor activity and c-Fos expression in the core, shell, straitum area. Conclusion : These results demonstrated that reduction in locomotor activity by Radix Scutellariae may be mediated by reduction of dopamine release and of postsynaptic neuronal activity in striatum, the nucleus accumbens. Out results show neurochemical evidence for the biological effects of Radix Scutellariae that ultimately may help us to understand how Radix Scutellariae can be used to treat nicotine addiction.

용규(龍葵) 추출물이 백혈병 세포의 Apoptosis 유도에 미치는 영향

장규태,Chang, Gyu-Tae 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1

Objectives In human myeloid leukemia cells, there are no specific features of apoptosis compared with apoptosis in other cell types. Solanum nigrum L.(SNL) is a deciduous tree, which is widely distributed in Korea with reported anti-tumor, anti-inflammatory and non-specific immune-enhancing properties. Although the plant has been clinically used for treating a variety of diseases, its bioactive ingredients are unknown and its mode of action potential has never been investigated. Thus anti-tumor property of methanol extract was investigated. Methods In this study, anti-tumor property of methanol extract was investigated by determining its in vitro growth-inhibitory effects on human myeloid leukemia cells. XTT proliferation assay, DNA fragmentation, immunoblot analysis, densitometric analysis were used. Results 1. The methanol fraction of the extracts of SNL induced mitochondria-mediated apoptosis in human myeloid leukemia cells. 2. The methanol fraction exhibited relatively higher cytotoxic activity in a dose-dependent manner than chloroform, and hexane fraction. 3. Typical ladder profile of Oligonucleosomal fragments were appeared. 4. The secreted cytosolic cytochrome C level was increased by treatment of methanol fraction. Conclusions Methanol fraction of SNL is capable of inducing apoptosis in human myeloid leukemia cells.

돼지 미성숙란의 체외배양시 MAP Kinase의 활성

장규태,박미령,윤창현 한국동물생명공학회(구 한국동물번식학회) 1998 Reproductive & developmental biology Vol.22 No.3

야뇨의 병력청취 연구

장규태,김장현,오주영,Chang, Gyu-Tae,Kim, Jang-Hyun,Oh, Ju-Young 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2

Objectives : In evaluating a child with enuresis, an organized approach to the history leads to a working diagnosis and an appropriate treatment plan. but, there's no study about history taking in enuretic children. This article was undertaken to evaluate the enuretic child exactly and to study nocturnal enuresis systematically. Methods : It was conducted a computerized literature search in following database: Medline (via Pubmed), NDSL, EBSCO. Korean articles via oriental pediatric association homepage, KISS. Key words to search were 'nocturnal enuresis', 'bedwetting', 'enuresis', 'incontinence', 'management', 'evaluation', 'assessment', 'questionnaire', 'guideline', 'voiding dysfunction'. Results : Questions are grouped in eight categories: primary history(sex, age, height, weight), family history, enuresis history(primary/secondary, frequency, time of enuresis, nocturia), voiding history(average number, frequency, pattern, volume, posture, daytime enuresis), medical history, constipation/encopresis, sleep(OSA). Conclusion : A careful, complete history taking will help to plan treatment properly and to study.

전염성 단핵구증의 중의학(中醫學) 연구(硏究)에 대한 고찰(考察)

장규태,Chang, Gyu-Tae 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2

Objectives : Infectious mononucleosis is a clinical syndrome caused by Epstein-Barr virus that is particularly common in adolescents and children. This study was progressed for current oriental medical treatment of infectious mononucleosis in china. The purpose of this study is the opening oriental medical approach to infectious mononucleosis in Korea Methods : Authors conducted a literature search in data of Traditional Chinese Medical Journal. The data were extracted in a standardized, predefined manner and accessed critically. Results : The study for infectious mononucleosis consists of basic, clinical, experimental study. Basic study consists of etiology & pathogenesis and the rule of treatment. Clinical study consists of symptoms-based treatment and adequate prescription treatment. Experimental study consists of effective herbs and new traditional chinese medical injection. Conclusion : Traditional chinese medical approach using herbs works in children with infectious mononucleosis in Korea.

대한한방소아과학회지에 수록된 논문의 분석 및 고찰

장규태,김장현,서영민,Chang, Gyu-Tae,Kim, Jang-Hyun,Seo, Young-Min 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.1

Objective: Organization of articles have study design, make hypothesis, sample gathering, statical analysis and feasibility of conclusion and medical articles must be continuously published and be continuously monitored in order to raise the quality of research. Main characteristics of oriental pediatrics research in korea can be summarized as the increase of the number and the advances methodology in research. The purpose of this study was to analyze the trends and evaluate the level of oriental pediatrics. Methods: The subjects were 244 articles published during the from 1986 to 2002 in 'The Journal of Korean Oriental Pediatrics' In this study, all the articles pressed in this journal were divided into three classes, Iiteratural, experimental and clinical articles and these were surveyed their chronological and thematic distribution Results: Classifying the articles in the journal of the korean oriental pediatrics, there were 103(42.2%) literatural articles, 90(36.9%) clinical articles, 51(20.9%) experimental articles. Clinical articles is gradually increasing although Iiteratural articles is decreasing. About disease in oriental pediatrics, immunoactivity was 13, rhinitis and growth was 12, allergy was 11 and diarrhea was high frequent in literatural articles, statistics of chief complaints and rhinitis was high frequent in clinical articles, immunoactivity was high frequent in experimental articles. Conclusions: As can be seen from the above results, there has been many these published using various experimental methods and relating to oriental pediatrics on the symptoms and diseases and their treatments, but unfortunately they were not enough the transmission of meaning of theses and contribution of learning, because how to do theses was not unifonn and description was not evident. It is needed more careful attention and study in the method of theses works in order to further develop the specialty of oriental pediatrics.

사육탕가미방(四六湯加味方)이 흰쥐의 학습(學習) 및 기억(記憶)에 미치는 영향(影響)

장규태,김장현,박보경,Chang, Gyu-Tae,Kim, Jang-Hyun,Park, Bo-Kyoung 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.1

Objective: This study was conducted to find out the effect of saruktanggamibang(SRT) on memory and learning of rats. Methods: The mon·is water maze was used. It was performed Acquisition test, Retention test of water maze. After Behavioral test, it was investigated AChE cell numbers of CAI and CA3 on hippocampus. Results: of water maze revealed that acqusitive abilities of SAP+SRT group significantly improved on 3, 4, 5th day compared with SAP+Saline group. Retention test of water maze didn't reveal that retentive abilities of SAP+SRT group significantly improved comparing with another group. ChAT cell numbers of medial septum of SAP+SRT group significantly increased compared with SAP+Saline group. AChE cell numbers of CAl and CA3 on hippocampus of Sham+SRT group significantly increased compared with Sham group. And AChE cell numbers of CAl and CA3 on hippocampus of SAP+SRT group significantly increased compared with SAP+Saline group. Conclusion: Saruktanggamibang(SRT) has an effect on memory and learning of rats.

한방병원 야뇨 환아의 후향적 연구

장규태,김장현,오주영,Chang, Gyu-Tae,Kim, Jang-Hyun,Oh, Ju-Young 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.1

Objective: The aim of this study was to investigate enuretic children attending oriental hospital and classify subtypes and evaluate possible factors that enhance or hamper of continence. Methods: Children attending kyeongju dongguk oriental hospital pediatrics between January 2000 and December 2003 with chief complaint of nocturnal enuresis were enrolled. The data of present symptoms and improvement progress was collected via telephone interviews with their parents. Results: The total number of children was 61. 32 of them were male and 29 female. Sex ratio was 1.1:1. Patient under 6 years of age was 68.8%. Using acupuncture, acupressure or chimsband with herb medicine, treatment frequency was increased. Patients with nocturnal enuresis(NE) was 48, and primary nocturnal enuresis(PNE) 39, secondary (SNE) 9. 13 was impossible to diagnose. The ratio of male to female was 1:1.09. PNE was 4 times as many as SNE. Male was predominent in PNE, and female in SNE. In the progress of PNE, male and female were similiar. but SNE, male was all cured, female remained 50%. And elapsed time of male to improve was longer than that of female. In the progress of improvement, many parents mentioned that their child was improved spontaneously regardless of subtype. Conclusion: We consider age, sex distinction, subtype, bladder symptoms, frequency, time of progress as influencing factor of prognosis, but failed to verify significance. To develop guideline of NE and find influencing factor of prognosis, more prospective study through taking history carefully and using questionnaire is needed.

모 한방병원 소아과 외래 환자의 주소증에 대한 연구 ('01-'04년)

장규태,김장현,최은영,Chang, Gyu-Tae,Kim, Jang-Hyun,Choi, Eun-Young 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.2

Objective : The purpose of this study was to investigate chief complaints of pediatric outpatients .Fin the oriental hospital and search for a trend of patients and their symtoms. Method : The study was composed of 2,915 new patients aged between 0 and 20 who had been visited pediatrics in ${\bigcirc}{\bigcirc}$ university oriental hospital from 2001 to 2004. Results : The percentage of new patients decreased every year with 30.7% in 2001, 25.5% in 2002, 24.1% in 2003, 17.8% in 2004. The age distribution showed 9.9% in infancy patients, 62.6% in early childhood, 16.8% in late childhood, 10.6% in adolescence. The percentage of infants decreased every year with 13.3% in 2001, 9.4% in 2002, 8.8% in 2003, 7.1% in 2004. The percentage of adolescents increased every year with 8.0% in 2001, 9.6% in 2002, 12.8% in 2003, 13.5% in 2004. Systemic division of chief complaints was respiratory symtoms(37.6%), general symtoms(26.1%), digestive symtoms(19.2%), skin symtoms(6.8%), nervous and mental symtoms (6.1%), urinary symtoms(2.2%), musculoskeletal symtoms(1.3%) and others(0.7%) in order of frequency. The main chief complaints were nasal mucus/obstruction(17.5%), weakness(16.9%), cough(12.8%), loss of appetite(9.8%), inappropriate growth(4.3%), atopic skin problem(3.4%), repeated common cold(2.4%), abdominal pain(2.4%), vomiting (2.2%), diarrhea(2.0%) and fever (1.9%). Loss of appetite, inappropriate growth and repeated common cold increased every year. Diarrhea and convulsion decreased every year. Conclusions : The two main causes of visit of patients were respiratory problems and improvement of general condition. More data of patients should be accumulated for further study. Not only analysis according to chief complaint, but also analysis according to diagnosis will accomplish more aaccurate information about disease of childrens in the future.