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영지(靈芝)버섯(Ganoderma lucidum)의 소화기계(消化器系)에 대한 약효연구(藥硏究)
정명현,엄기진,이병주,임기룡,Chung, Myung-Hyun,Um, Kie-Jin,Lee, Byung-Joo,Rim, Gi-Ryong 한국생약학회 1993 생약학회지 Vol.24 No.2
This study was attempted to investigate the effect of Ganoderma lucidum extract on digestive system in experimental animals. Ganoderma lucidum water extract (GWE) was found to be promoted the charcol transport rate in the small intestine of mice. GWE exhibited the augmentation of spontaneus movement(motility) and contractile response(tension) in the ileum and colon strips of rabbit, and these action were inhibited by atropine. GWE given intraduodenaly(i.d.) exhibited the significant increase of gastric acid secretion in pylorus-ligated rats. GWE inhibited the formation of some experimental gastric ulcers(pylorus ligation ulcer i.d., indomethacin-induced ulcer p.o., i.d. and aspirin-induced ulcer p.o.) in rats, which are considered to relate to a protective action. GWE and EtOH extract(water soluble phase) were remarkably increase of bile excretion, when administration of i.d., intravenation(i.v.) and per os (p.o.) compared with normal-control group. GWE was observed antibacterial activity aginst several intestinal microoganisms and others bacteria in vitro test.
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문영희(Young Hee Moon),임기룡(Gi Ryong Rim) 한국생약학회 1995 생약학회지 Vol.26 No.1
The bark of Ulmus parvifolia Jacq. (Ulmaceae) has been used for the treatment of gonorhea, edema, scabies and eczema marginatum. Previous investigations conducted with the heartwood and leaves have demonstrated it to contain sesquiterpenes as well as fat acids from the heartwood and flavonol glycosides from leaves. However, no phytochemical work has been done on the bark parts of this plant. Investigation of the phytochemical constituents in the barks of U, paruifolia has resulted in the isolation of sterols, sterol glucoside and a catechin glycoside, (+)-catechin 7-O-α-L-rhamnopyranoside, all of which were isolated for the first time from this plant. Sterols were consisted of the three components, β-sitosterol, stigmasterol and campesterol in a ratio of 92.1 : 4.1 : 3.8, and sterol glucoside was identified as b-sitosterol 3-O-β-D-glucoside. The structure of the catechin 7-O-α-L-rhamnoside was established primarily by analysis of ¹H- and COSY-45 NMR, PIMQC and HMBC and EI mass spectra of the heptaacetate. Especially, HMBC spectrum provides effective way for the determination of the point of attachment of the rhamnosyl group to catechin moiety.
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