1-MCP 처리에 의한 절화 아이리스 개화율 개선 및 수명연장

남진수(Jin Soo Nam),박인숙(In Sook Park),심성임(Sung Im Shim),임기병(Ki Byung Lim) 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.10

Flangeless Esser PET Phantom 영상 자동 분석 프로그램의 유용성 평가

남궁창경,남기표,김경식,김정선,임기천,신상기,조시만,동경래,NamGung, Chang-Kyeong,Nam, Ki-Pyo,Kim, Kyeong-Sik,Kim, Jeong-Seon,Lim, Ki-Cheon,Shin, Sang-Ki,Cho, Shee-Man,Dong, Kyung-Rae 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1

Purpose: ACR (American College of Radiology) offers variable parameters to PET/CT quality control by using ACR Phantom. ACR Phantom was made to evaluate parameters which are uniformity, attenuation, scatter, contrast and resolution. Manual analysis method wasn't good for the use of QC because values of parameter were changed as it may user and it takes long time to analysis. Ki-Chun Lim, a nuclear scientist in AMC, developed program that automatically analysis values of parameter by using ACR Phantom to overcome above problems. In this study, we evaluated automatic analysis program's usability, through the comparing SUV of each method, reproducibility of SUV when repeated analysis and the time required. Materials and Methods: Using Flangeless Esser PET Phantom, the ideal ratio of 4 : 1 hot cylinder and BKG but it actually showed a ratio of 3.89 to 1 hot cylinder and BKG. SIEMENS Biograph True Point 40 was used in this study. We obtained images using ACR phantom at Fusion WB PET Scan condition (2 min/bed) and 120 kV, 100 mAs CT condition. Using True X method, 3 iterations, 14 subsets, Gaussian filter, FWHM 4 mm and Zoom Factor 1.0, $168{\times}168$ image size. We obtained Max. & Min. SUV and SUV Mean values at Cylinder (8, 12, 16, 25 mm, Air, Bone, Water, BKG) by automatic program and obtained SUV by manual method. After that, we compared manual and automatic method. we estimate the time required from opened the image data to final work sheet was completed. Results: Automatic program always showed same result and same the time required. At 8, 12, 16 and 25 m cylinder, manual method showed 6.69, 3.46, 2.59, 1.24 CV values. The larger cylinder size became, the smaller CV became. In manual method, bone, air, water's CV were over 9.9 except BKG (2.32). Obtained CV of Mean SUV showed BKG was low (0.85) and bone was high (7.52). The time required was 45 second, 882 second respectably. Conclusions: As a result of difference automatic method and manual method, automatic method showed always same result, manual method showed that the smaller hot cylinders became, the lager CV became. Hot cylinders mean region size, the smaller hot cylinder size becomes we had some trouble in doing ROI poison setting. And it means increase in variation of SUV. The Study showed the time required of automatic method was shorten then manual method.

절화 장미의 염색에 미치는 몇 가지 요인

심성임(Sung Im Sim),남진수(Jin Soo Nam),박인숙(In Sook Park),임기병(Ki Byung Lim) 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.10

절화장미 Akito에서의 단색 및 복색 염색화를 제작을 위한 최적조건 규명

심성임(Sung Im Shim),남진수(Jin Soo Nam),임기병(Ki-Byung Lim) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.5

PET 검사에서 Iterative 재구성 방법과 True X 재구성 방법에 따른 영상의 균일성 및 대조도 비교 평가

최재민,남궁창경,박승용,남기표,임기천,Choi, Jae-Min,NamKung, Chang-Kyeong,Park, Seung-Yong,Nam, Ki-Pyo,Lim, Ki-Cheon 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1

목적 : 최근 기존의 PET 영상에 비하여 신호 대 잡음비를 높이고, 전체 가시영역에서 우수한 공간분해능을 보이는 새로운 영상 재구성 방법이 소개되었다. 본 연구는 Siemens PET/CT장비에 새롭게 적용된 True X 재구성 방법의 임상적용에 대한 유용성 평가를 위해 현재 일반적으로 사용되고 있는 Iterative 재구성 방법과의 차이를 모형시험을 통해 영상의 균일성과 대조도를 비교 평가하였다. 실험재료 및 방법 : 본 연구를 위한 모형의 제작은 열소와 배후방사능의 비율이 4:1이 되도록 F-18을 물에 혼합하여 모형에 채웠다. 영상의 획득시간은 Bed당 2분으로 하였고 영상의 재구성 조건은 Iteration은 2,3 Subset은 14로 변경하여 재구성하였다. 재구성 방법의 차이에 따른 영상의 균일성을 평가하기 위해 Iterative와 True X로 재구성한 영상에 각각 관심 영역을 설정하여 관심영역의 변이 계수를 측정 비교하였고, 대조도 평가는 열소와 배후방사능에 관심영역을 설정하여 평균섭취 계수를 측정 비교하였다. 결과 : 균일성을 평가하기 위한 변이계수는 Iterative, 2 Iteration 14 Subset에서 13.84%, 3 Iteration 14 Subset에서는 19.04%로 측정되었다. True X, 2 Iteration 14 Subset에서 6.06%, 3 Iteration 14 Subset에서는 10.76%로 측정되었다. 대조도 평가에서 재구성 방법을 Iterative, 2 Iteration, 14 Subset으로 설정했을 때 열소의 크기 25, 16, 12, 8 mm에서 평균섭취 계수비는 각각 3.08:1, 2.89:1, 2.32:1, 1.66:1로 나타났고 평균치는 2.458:1이였다. True X에서는 25, 16, 12, 8 mm에서 각각 3.65:1, 3.53:1, 2.7:1, 1.66:1이였고 평균값은 2.882:1로 나타났다. 재구성 조건을 3Iteration, 14 Subset으로 변경하였을 때 Iterative에서는 25, 16, 12, 8 mm에서 각각 3.08:1, 2.90:1, 2.47:1, 1.87:1로 평균치는 2.596:1이였고 True X는 25, 16, 12, 8 mm에서 각각 3.5:1, 3.45:1, 2.93:1, 1.83:1로 평균 비율은 3.33:1이였다. 결론 : 균일성 비교 평가에서 True X와 Iterative 재구성 방법 모두 2 Iteration, 14 Subset이 3 Iteration, 14 Subset 보다 균일한 영상을 형성하였으며, 전반적으로 True X가 Iterative 재구성 방법보다 균일성이 고르게 나타났다. 대조도는 Iterative 재구성 방법, True X 모두 3 Iteration, 14 Subset에서 2 Iteration, 14 Subset보다 실제와 가까운 평균섭취 계수비를 나타냈다. 그러나 이러한 데이터는 모형만을 이용한 방법이므로 실제 임상에서 가장 정확하고 유용한 진단적 정보를 제공하기 위한 연구를 더 해야 하며, 임상 검사에 맞는 최적의 Iteration과 Subset 조건을 찾아야 할 필요성이 있다고 사료된다. Objective: In this study, the differences between two reconstruction methods were analyzed by comparing image uniformity and contrast according to Iteration and Subset, which were altered through the Iterative method and True X method, used in Siemens' PET/CT studies. Methods: The Phantom images were obtained by exposure for two minutes per one bed. To determine the image uniformity, the Coefficient of variance was used. Also, in order to compare the contrast value, we measured and analyzed the ratio of the SUV mean of Phantom image's hot spheres and the background. Results: Under the same reconstruction conditions (Iteration and Subset) of CV, the Iterative method was higher than the True X method. In the comparison of the SUV mean ratio of the background and hot sphere, the True X method had a closer rate than the Iterative method. Conclusion: The newly developed True X reconstruction method is better than the previously used Iterative method in terms of uniformity and contrast. However, the date for this study was only obtained using the Phantom device. In order to obtain more accurate and useful information from the experiment, further research should be conducted. Also, it is necessary to find the appropriate standards for Iteration and Subset for further experimentation.

Comprehensive in vitro Proarrhythmia Assay (CiPA) 기반 Torsade Metric Score (TMS)를 이용한 TdP 발생 약물의 위험군 분류 성능 평가

윤승현 ( Seung-hyun Yoon ),남유리 ( Yu Ri Nam ),강현수 ( Hyun-su Kang ),정다운 ( Da Un Jeong ),유예담 ( Ye Dam Yoo ),임기무 ( Ki-moo Lim ),박성준 ( Seong-jun Park ),김배환 ( Bae-hwan Kim ),김기석 ( Ki-suk Kim ) 한국동물실험대체법학회 2021 동물실험대체법학회지 Vol.15 No.1

For the assessment of cardiotoxicity and Torsade de Pointes (TdP), a fatal arrhythmic symptom, ICH S7B and E14 guidelines were presented. However, focusing on hERG block, which are essential determinants of arrhythmic risk, may unexpectedly limit drug development by increasing the risk of drugs that are actually non-toxic. To compensate for these problems, the Comprehensive in vitro Proarrhythmic Assay (CiPA) project was proposed. In this study, based on the CiPA project and previous studies, the nine drugs were tested using in vitro multiple ion channel screening on both temperature conditions (room temperature and 37℃). Using the in vitro results, in silico computer simulation was performed based on the O'Hara-Rudy human ventricular myocyte model, and same as the CiPA project obtained a new biomarker, qNet. The in silico computer simulation was performed using 2000 samples of IC₅₀ values extracted by R code. The nine test drugs were associated with cardiotoxicity and TdP, and were selected by the CiPA project and previous studies. Furthermore, as in previous studies, Torsade Metic Score (TMS), the mean qNet value averaged across 1-4 × Cmax, and the threshold was calculated. As a result, the nine tested drugs using the TMS were well plotted by the risk categories and the threshold was able to well classify the risk categories by grade on both temperature conditions. In particular, the threshold 2 value confirmed to significant difference depending on the temperature conditions. The range of threshold narrowed at 37℃, which can be considered as having the ability to distinguish more finely. It shows the correlation with the CiPA project’s validity that a study should be tested at a physiological temperature of 3 7℃. In this study, using the method proposed by the CiPA project, it was possible to predict the risk groups of drugs more accurately, which could be presented as a new paradigm in the cardiotoxicity assessment.

룰드 곡면으로 된 임펠러의 5축 황삭 가공에 관한 연구

장동규(Dong Kyu Jang),임기남(Ki Nam Lim),양균의(Gyun Eui Yang) Korean Society for Precision Engineering 2007 한국정밀공학회지 Vol.24 No.7

This paper presents an efficient 5-axis roughing method for centrifugal impeller. The efficient roughing is minimization of cutting time through minimizing tool tilting and rotating motions. To minimized cutting time, machining area is divided into sub-cutting regions using control points on hub curves and shroud curves of blade used to design and analyze centrifugal impeller. For sub-cutting regions, diameters of cutting tools are determined as big as possible. Then, tool paths are generated with the tilting axis and rotating axis of 5-axis machine limited and fixed, which can give more efficient machining speed and machining stability than the conventional methods. Experimental results show that the proposed method is more efficient than the conventional methods to mill with the only one cutting tool without dividing area and the previous methods to mill with simultaneous 5-axis processing with dividing area.