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ATP 의존성 K+ Channel 차단작용이 있는 Glibenclamide 가 개의 신장기능에 미치는 영향
고석태(Suk Tai Ko),임광남(Kwang Nam Yim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.3
Glibenclamide(GLY)(1.0 and 3.0 mg/kg), an ATP-dependent K^+ channel blocker, when given into the vein in dogs, produced the diuretic action accompanied with the increase of osmolar clearance(C_(osm)), urinary excretion of Na^+ and K^+ (E_(Na+), E_K), and with the decrease in reabsorption rates for Na^+ and K^+ in renal tubules (R_(Na), R_K), and then ratios of K^+ against Na+ (K^+/Na^+) were decreased. GLY did not affect mean arterial pressure at any doses used. At a low dose(0.1 mg/kg), GLY injected into a renal artery brought about the diurectic action in both experimental and control kidney, however at a higher dose(0.3 mg/kg), GLY appeared significant diuretic action in the control kidney, but not in experimental kidney and the decrease of glomerular filtration rates(GFR), renal plasma flow(RPF), E_K, and the increase in E_(Na+). In the control kidney, these changes in renal function exhibited the same aspect as shown in intravenous experiments. In experiments given into carotid artery of GLY(0.5 and 1.5 mg/kg), changes in all renal function included the increase in urine volume were the same pattern as shown in intravenous experiments. The above results suggest that glibenclamide produces diuretic action through central function and the action site of the GLY in kidney is the renal distal tubules in dogs.
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