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대식세포에서 폐렴구균 협막 다당류에 의한 TNF-α 및 Nitric Oxide 생성
엄성희(Sung Hee Um),엄진섭(Jin Sub Um),인상환(Sang Hwan In),문은이(Eun Yi Moon),이동권(Dong Kwon Rhee),표석능(Suhk Neung Pyo) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.1
Capsular polysaccharides (CPs) from Streptococcus pneumoniae were examined for the ability to induce secrefory responses in a pure population of peritoneal macrophages. The highly purified CPs were able to affect the macrophage, ie, secretion of tumor necrosis factor-alpha(TNF-α) and nitrite. As after stimulation with CPs, secretion of TNF-αinduced by these CPs reached its maximum within the first few hours of the interaction, while secretion of nitrite was increased with time. In addition, production of TNF-αand nitrite was increased in a dose-dependent manner. In the presence of indomethacin, CP-stimulated TNF-αproduction was not altered. In contrast, LPS with indomethacin stimulated 24.5% more TNF-αthan LPS alone, suggesting that the intracellular signaling processes for TNF production are differentially stimulated by CP and LPS. The results demonstrate that CPs are potent inducer of macrophage secretory activities.