FK506이 T 림프구 사멸에서 활성산소 생성에 미치는 영향

이호균(Ho Kyun Lee),정상영(Sang Young Chung),최수진나(Soo Jin Na Choi) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.5

Purpose: Tacrolimus (FK506) has been widely used as an immunosuppressant in organ transplanted recipients to suppress organ rejection phenomenon. We investigated the role of oxidative stress and heme oxygense-1 by FK506 on human Jurkat T cells. Methods: The cells viability was examined by DAPI stain, enzyme activity of caspase family proteins, and western blotting for Baks, PUMA, iNOS, HO-1. Cells were cultured in the absence or presence of CoPPIX or ZnPPIX and the fluorescence intensity was analyzed using a flow cytometry. Results: Treatment with FK506 increased the generation of reactive oxygen species (ROS), including hydrogen peroxide and superoxide anion, and NO in Jurkat cells in a dose-dependent manner. Immunohistochemistry and Western blot analysis data revealed the hemoxygenase-1 (HO-1) was induced by the addition of FK506 in Jurkat cells. Induction of CoPP, HO-1 inducer, resulted in decreased intracellular H₂O₂ and NO concentrations. Instead ZnPP, an HO-1 competitive inhibitor did it reversely. In addition, ZnPP regulates iNOS protein synthesis by inhibition of HO-1. Conclusion: Increase of HO-1 expression would induce to decrease the intracellular H₂O₂ and NO concentrations. Also, HO-1 would regulate iNOS protein synthesis. Consequently, we can expect the regulation of HO-1 expression with concomitants use of FK506 to suppress organ rejection phenomenon by enhancing apoptosis.

도시철도 유지보수 예방정비체계 구축 방법론에 관한 연구

이호용(Ho-Yong Lee),한석윤(Seok-Youn Han),박기준(Kee-Jun Park),배철호(Chul-Ho Bae),서명원(Myung-Won Suh) 한국철도학회 2004 철도저널 Vol.7 No.3

The safety of staff, customers and of general Public in general viewed as one of the most important requirements in the urban transit. The maintenance computerization system for car of urban transit is a part of standardization and development of urban transit system, and We have been performed the establishment of maintenance computerization system from 2001 to 2005. The RAMS (reliability, availability, maintainability and safety) estimation for maintenance computerization system are utilized in a variety of computerization system for user's convenience and safety in maintenance. Ever since its inception though, the urban transit has searched for ways to improve reliability, availability, maintainability and safety of the railway subsystem. Provision of a reliable maintenance system include RAMS of the vehicles plays a very important role in achieving a safe system.

구연발표 : 5-Amirosalicylic acid가 Deoxycholate 로 유발된 대장 점막의 O2- 및 산화효소제에 미치는 영향

이호심(Ho Sim Lee),김호정(Ho Jung Kim),장세경(Sae Kyuong Chang),박실무(Sil Mu Park),김종숙(Jong Sook Kim) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

사출압축성형을 이용한 자동차용 도어그립 필름인서트성형

이호상(Ho Sang Lee),유영길(Young Gil Yoo),김태안(Tae An Kim) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-3

물리식 기반 동적 재결정 모델을 이용한 열간 단조 공정의 미세조직 변화 예측

이호원(Ho Won Lee),이영선(Young Seon Lee),강성훈(Seong Hoon Kang) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-3

대학의 산학협력 무역인력 양성이 중소기업 수출성과에 미치는 영향

이호형(Ho-Hyung Lee) 한국통상정보학회 2015 통상정보연구 Vol.17 No.2

대학 무역교육에 현장실무지식과 현장실습을 접목하는 교육 방식이 활성화되고 있는 현상은 무역인력의 질적 수준 향상에 큰 기여를 하고 있다. GTEP, LINC, 학과 또는 강의 단위 산학협력형 무역교육 등을 전부 조사하여 분석한 결과 해외전시회 참가를 중심으로 중소기업의 수출성과 확대에 실질적인 기여를 하고 있다. 산학협력을 경험한 학생이 졸업 후 해당 기업에 취업하면서 청년취업 문제가 해소되고 중소기업에 맞춤형 무역인력을 공급할 수 있는 연쇄적인 성과도 나타나고 있다. 산학협력 무역교육을 경험한 대학생 100명을 대상으로 설문조사를 실시한 결과 정보화 능력, 외국어 능력이 가장 높게 나타났고 제품/기술에 대한 지식이 가장 낮은 것으로 나타났다. 산학협력을 통해 해외시장에 진출한 50개 기업을 대상으로 조사한 결과 수출성과 달성에는 산학협력 방식의 대학생 무역교육 후 수료생의 역량 향상이 성공요인으로 나타났다. Trade education methods that combine practical knowledge and on-site job training have significantly contributed in improving abilities of trade experts. For instance, GTEP and LINC have contributed to a substantial expansion of SME export performane. Moreover, students’ cooperation experience have led to employment outcomes as SMEs can employ customized trade workers. I have conducted a survey to 100 students about university-industry collaboration. Results show that ICT skills and foreign language ability are the highest required conditions of employment while production and technology knowledge are the lowest. Furthermore, 50 companies operating in foreign markets responded that through industry-university cooperation, capabilities of university graduates have improved and trade education cooperation scheme is a success.

우리나라 목재산업 및 시장 동향

이호상 ( Ho Sang Lee ),김철상 ( Chul Sang Kim ),김동현 ( Dong Hyeon Kim ),전현선 ( Hyon Sun Jeon ),윤나영 ( Na Young Yoon ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-

2013년 목재 및 나무제품 제조업의 생산량은 증가하였지만, 국내 건설경기의 불황이 지속되면서 재고량이 증가하고 있다. 펄프, 종이 및 종이제품 제조업은 2013년 2월 이후 10개월 연속 출하량 이 증가가 이어져오고 있다. 2013년 목재수급량은 2012년 27,819천㎥보다 332천㎥ 증가한 28,151천㎥으로 나타났다. 국산재 생산량(벌채수집 기준)은 5,038천㎥로 전년대비 6.2% 감소하였고, log 수입량은 3,757천㎥로 전년도 대비 1.9% 증가하였다. 뉴질랜드산 라디에타 소나무는 원목 총 수입량의 72%를 점유하였다. 뉴질랜드산 Radiata Pine(A-grade, C&F)의 2013년 연평균 수입 가격은 145$/㎥로 중국의 원목 수입량이 크게 증가하여 전년대비 14$/㎥ 상승하였다. 남양재 원목은 산지의 부존자원과 기후의 영향으로 생산량이 감소하고 중국 등 수입국의 수요 증가로 가격은 상승세가 지속될 것으로 보인다. 목재제품 중 제재목 수입량은 1,756천㎥로 전년대비(1,623천㎥) 8.2% 증가하였다. 이는 최근 우리나라 목재류 수입의 특징으로 원목수입량은 감소하는 반면, 1차 가공품의 수입량이 증가하고 있기 때문이다. 또한 plywood, MDF, PB 생산량은 0.6~2.8% 감소하였고 수입량은 2.4~15.3% 증가하였다. 목질 보드류의 수입량이 증가하는 것은 국내업체의 생산 능력과 원자재 수급 및 제품의 가격 경쟁의 한계로 분석되었다. While the production volume of 2013 increased in lumber and wood product manufacturing, the total stock has also been growing as the economic recession and stagnation in construction continue. Also, the shipment of pulp, paper and paper product manufacturing has continuously risen for 10 months since Feb 2013. The amount of wood supply and demand of 2013 was 28,151,000㎥, 332,000㎥ up from 27,819,000㎥ of 2012. The domestic lumber production (as of felling and collection volume) was 5,038,000㎥, falling by 6.2% from the previous year and the amount of log imports increased by 1.9% year on year to 3,757,000㎥. Radiata pine accounted for 72% of the total import volume. Its annual average import price of 2013 increased by 14$/㎥ from the previous year to 145$/㎥, as the import from China largely increased. The amount of Oceania timber production, however, has decreased due to the affect of the natural resources and climate while its price is expected to show rising trend. Meanwhile, the import amount of sawing lumber among wood products increased by 8.2% to 1,756,000㎥ from 1,623,000㎥ of the previous year. This reflects the national import trend of the wood products in which while the import amount of lumber continued to decrease, that of primary processed goods increased. Also, the amount of plywood, MDF, and PB production decreased 0.6~2.8% and their import amount increased by 2.4~15.3%. The limitation of the ability of domestic business to produce, the supply and demand of raw materials and the competitive prices were pointed as some reasons of the trend that the amount of imported woodboard products has continuously increased.

한방병원 유형화 분석

이호정 ( Ho Jung Lee ),김경성 ( Kyung Sung Kim ),박상준 ( Sang June Park ) 한국항공경영학회 2009 한국항공경영학회지 Vol.7 No.3

The oriental hospitals in Korea has entered into ultimate competition. Since suffering from long run of financial crisis after the currency devaluation, they have been getting worse due to the exponential increase in the number of the oriental hospitals. Consequently the oriental hospitals have tried to differentiate them from competitors, but only a few of them have found their differentiated positions. In this study, we figure out the present situations and the current state of the oriental hospitals by analyzing the Korean medical market. Based on the financial data of oriental hospital, additionally, we classify them into the several groups in which each hospital has the same strategy and then derive some managerial implications on differentiation strategies for the oriental hospitals. We believe that this study might be helpful in trying to enhance survival possibilities of the oriental hospitals in Korea.

수성탐사 역사 및 베피콜롬보 현황

이호형(Lee, Ho-hyung) 한국항공우주연구원 2017 항공우주산업기술동향 Vol.15 No.1

수성탐사에서는 수성이 태양에 매우 가까이 있기 때문에 수성까지 도달하는데 어려움이 있었고, 태양 가까이 수성 주위에서의 혹독한 온도환경을 이겨 내는 것이 어려운 문제였다. 지금까지 수성탐사는 미국항공우주국(NASA)에 의하여 마리너 10과 메신저 우주선으로 2회 수행된 바 있다. 유럽에서는 유럽 최초의 수성탐사 프로젝트이자 세계에서 세 번째 수성탐사 프로젝트인 베피콜롬보가 1993년 제안되어 2018년 10월 발사를 목표로 하고 있다. 본 논문에서는 이전의 수성탐사 관련 내용을 간단히 소개하고, 베피콜롬보 프로젝트에 대해서 상세히 소개했다. In Mercury exploration, because the Mercury is very close to the Sun, it was difficult to travel to the Mercury, and overcoming the severe thermal environment around the Mercury near to the Sun was a difficult problem. Until now, Mercury exploration was performed twice by NASA by using Mariner 10 and Messenger spacecrafts. In Europe, the first European mission to Mercury, which is the third mission to Mercury in the world, BepiColombo, had been proposed in 1993 and is scheduled for launch in October 2018. In this paper, previous Mercury missions will be briefly introduced, and the details of the BepiColombo mission will be presented.

사출성형에 의한 디스크의 복굴절

이호상(Ho Sang Lee) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5