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자국경부선암에서 Fragile Histidine Triad (FHIT) 단백의 발현과 임상병리학적 예후인자와의 관계에 대한 연구
이택상 ( Taek Sang Lee ),서동훈 ( Dong Hoon Suh ),강순범 ( Soon Beom Kang ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8
Objective: To investigate the expression of fragile histidine triad (FHIT) protein and the possible relationship between FHIT expression and clinicopathological indices in cervical adenocarcinoma. Methods: FHIT protein expression was examined in 40 cases of cervical adenocarcinoma stage Ia to IIa and 28 cases of corresponding normal endocervical tissue by immunohistochemical method. We analyzed the relationship between the reduction of FHIT protein expression and several prognostic factors such as histological grade, lymph node metastasis, tumor size, cervical invasion depth and parametrial invasion. We used Fisher`s exact test for statistical analysis. Results: The FHIT protein expression was positive in 77.5% (31/40) of cervical adenocarcinoma tissue, and reduced its expression in 22.5% (9/40) whereas positive in 100% (28/28) cases of adjacent normal endocervical gland. The FHIT expression was decreased in 14.3% (4/28) of cancers without lymph node metastasis but 55.5% (5/9) of those with metastasis (p=0.023). And the reduction of FHIT expression was found in 34.8% (8/23) of grade II and III cancers and only 6.3% (1/16) of grade I (p=0.056). Conclusion: Loss of FHIT protein expression may be associated with metastasis and poor prognosis of cervical adenocarcinoma.
이택상 ( Taek Sang Lee ),( Smita Kothari-talwar ),( Puneet K Singhal ),( Karen Yee ),( Amit Kulkarni ),( Nuria Lara ),( Montserrat Roset ),( Anna R Giuliano ),( Suzanne M Garland ),( Woong Ju ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objectives: To estimate self-reported human papillomavirus (HPV) disease-related psychosocial impact among male and female patients in South Korea. Design: In this multicentre cross-sectional study, psychosocial impacts were estimated using a onetime survey capturing HPV Impact Profile (HIP) results, CuestionarioEspecifico en Condilomas Acuminados (CECA; in Spanish)―‘Specific questionnaire for Condylomata Acuminata’ and the EuroQol-5 Dimension (EQ-5D) surveys. Student’s t-tests or Mann-Whitney U tests were used for continuous comparisons; χ<sup>2</sup> or Fisher’s exact tests were applied for categorical comparisons. Setting: 5098 clinics throughout Seoul, Busan, Daegu, Kwangju and Daejeon (South Korea). Participants: Patients with and without genital warts (GW) (males) and selected HPV diseases (females) visiting primary care physicians, obstetricians/gynaecologists, urologists and dermatologists with 2-30 years experience. Results: Of 150 male and 250 female patients, HIP scores showed 85.3% of male patients with GW and 32.0% without reported moderate psychological impact (p<0.0001). In categorised total scores, 88.5% of female patients with and 66.0% without selected HPV-related diseases reported moderate or high psychological impacts (p=0.0004). In the CECA questionnaire, male patients had mean (SD) scores of 10.51 (3.79) in ‘emotional health’ and 15.90 (6.13) in ‘sexual activity’. Female patients with GW reported lower scores in both dimensions with mean scores of 7.18 (4.17) in ‘emotional health’ and 10.97 (5.80) in ‘sexual activity’ (p<0.0001), indicating worse health-related quality of life (HRQoL). For the EQ-5D, male patients with GW reported lower mean Visual Analogue Scale (VAS) scores than those without (75.1 vs 81.13, p<0.0135). Mean VAS score and utility values were lower for females with HPV-related diseases than those without (72.18 vs 76.86 and 0.90 vs 0.94, respectively). Conclusion: In South Korea, GW in men and HPV-related diseases in women negatively impact patient well-being and HRQoL scores. Among women, those with GW suffered a greater psychosocial impact than those with other selected HPV-related diseases.
김성일(Sung Il Kim),한수연(Soo Yeon Han),윤형동(Hyung Dong Yoon),천은경(Eun Gyung Chun),이택상(Taek Sang Lee),이지영(Jee Young Lee),박중신(Joong Sin Park),전종관(Jong Gwan Jeon),윤보현(Bo Hyun Yoon),신희철(Hee Chul Shin) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.12
Korea is an endemic area for hepatitis B virus infection, so incidence of hepatocellular carcinoma resulting from liver cirrhosis is higher than in western countries. But pregnancy is rarely encountered in women with hepatocellular carcinoma, since hepatocellular carcinoma usually develops after childbearing ages. Additionally severe menstrual irregularity and infertility with disturbance of estrogen metabolism often accompany cirrhosis that is a most common underlying disease of primary hepatocellular carcinoma. Whether hepatocellular carcinoma progresses abruptly in pregnancy remains equivocal, because the experiences are lack. Anyway, early diagnosis by maternal serum AFP and abdominal sonography offers the potential for prevention of the disease progression and longer survival. Thus, we report 3 cases of primary hepatocellular carcinoma first detected on prenatal check during pregnancy with brief review of the literature.
강순범 ( Soon Beom Kang ),이택상 ( Taek Sang Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.6
Recently, multicenter clinical trials have been getting more popular inside and outside of the country. The disease pattern of our country is somewhat different from that of western countries in terms of its incidence, clinical feature. Therefore, the results of clinical studies in US or European countries cannot be properly applied without consideration of trial design features and intertrial comparisons. Therefore, the conduct of multicenter trial with our own population is necessary. Well organized multicenter trials having competitive power will make it possible to develop new treatment modalities, frame a reasonable policies for its clinical applications and ultimately contribute to improve national healthcare services.
임신중절에 대한 사회적 여건 변화에 따른 임신 중기 양수검사의 감소
전혜원 ( Hye Won Jeon ),이택상 ( Taek Sang Lee ),배광범 ( Kwang Bum Bai ),황규리 ( Kyu Ri Hwang ),김병재 ( Byung Jae Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.12
Objective: To investigate the effect of alteration of social conditions towards pregnancy termination on the acceptance of genetic amniocentesis. Methods: Retrospective review of medical records was conducted for women (<20 weeks` gestation, singleton pregnancy) who visited our outpatient department between February 1, 2009 and August 31, 2010. Acceptance of genetic amniocentesis was compared between two groups of women: one from February 1, 2009 to November 30, 2009 (2009 group) and the other from December 1, 2009 to August 31, 2010 (2010 group) after strict regulation of pregnancy termination. The acceptance rate of those who were referred to our center for genetic amniocentesis in same time period was also evaluated. Results: Overall, 19 of 101 (19%) women in the 2009 group and 10 of 93 (11%) in the 2010 group, opted for invasive diagnostic methods (P=0.16). Women > 35 years in the 2010 group (5/30, 17%) were less likely to accept genetic amniocentesis than 2009 group (15/30, 50%; P=0.01). Similar results were observed in those who were indicated for genetic amniocentesis. (9/35, 26% vs 19/34, 56%; P=0.02). Acceptance rate of genetic amniocentesis was increased for those who were referred from private clinic, but without statistical significance (15/21, 71% vs 13/14, 93%; P=0.20). Conclusion: After strict regulation of pregnancy termination, acceptance rate of genetic amniocentesis was significantly decreased among women who had increased risk for chromosomal abnormalities or neural tube defect at our center. Whereas, there were no significant change in acceptance rate for those who were referred for amniocentesis from private clinic.