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이창행(Chang Haeng Lee),최지훈(Jee Hoon Choi),백승국(Seung Kuk Baek),우정수(Jeong Su Woo),정광윤(Kwang-Yoon Jung) 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1
Out of entire salivary tumor, 1.7% are malignant lymphoma developed in salivary gland and it is usually mucosa associated lymphoid tissue (MALT) lymphoma developed in salivary gland. In the case of Non-Hodgkin lymphoma, the most frequently involved extanodal sites of diffuse large B cell lymphoma are bone, skin, thyroid, gastrointestinal tract, and lung. Development in salivary gland is very rare. A 69 years old male patient who have found Lt. submandibular gland (SMG) mass a month ago is suspected of malignancy from his FNA result, so histologic exam by SMG resection was operated. According to histopathologic exam, large B cell lymphocyte infiltratration were generally shown as diffuse and lymphoepitheliallesion were not found. In immunostaining, CD79a showed positive and CD3, CAM5.2 showed negative which diagnosed as diffuse large B cell lymphoma. As Ann Arbor stage I, CEOP-B chemotherapy was used 3 times as treatment without any recurrence. In the case of malignant lymphoma in salivary gland, it develops as painless mass in ipsilateral side. If found in parotid gland, it is rare to have facial nerve falsy and pathologically diagnosed as lymphocytes of abnormal type of monoclonal immunostaining must be provided as evidence. Combined therapy is known as most effective treatment for intermediate grade.
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김정준,최성배,이창행,임기정,오병훈,김은중,이흥만,이상학 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.4
Background and Objectives:A heparin-binding polypeptide called midkine is a family of secreted growth/differentiation cytokines and has a role in tumor growth by enhancing endothelial proliferation, vascular density and angiogenesis. In this respect, midkine may be involved in the pathogenesis of nasal polyposis. The aim of the present study is to evaluate the Materials and Method:The total RNA was isolated from freshly disected inferior turbinate of patients who underwent rhinoplasty and from nasal polyps of chronic rhinosinusitis patients. The expresion and distribution of midkine mRNA was investigated by reverse transcriptse- polymerase chain reaction (RT-PCR) and in situ hybridization. The midkine mRNA expression in nasal mucosa and polyps were semi-quantitatively evaluated by Southern blot hybridization. Results:The expression of midkine mRNA was identified in both normal inferior turbinate and nasal polyp. Histochemistry of In situ hybridization revealed that midkine mRNA in normal inferior turbinate was intensely expressed in the surface epithelium, submucosal glands, vascular endothelium, and inflammatory cells scatered in submucosal tissues. Midkine mRNA was expressed in the nasal polyps, many inflammatory cells and newly formed vascular endothelium, but not in the newly formed glandular epithelium. In semi-quantitative southern blot hybridization, midkine mRNAs did not have diferent expresion levels betwen inferior turbinate and nasal polyps. Conclusion:These results indicate that midkine mRNA is innately expressed in human nasal mucosa, playing a role in nasal physiology. Also, the results show that midkine may be involved in the pathogenesis of nasal polyps via angiogenesis, tissue growth, and inflamatory process. (Korean J Otolaryngol 2002;45:335-40)
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김준모,김형진,최성배,이창행,백승국,권순영,정광윤 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.5
Background and Objectives:To analyze results of treatment and prognostic factors in patients with T3 supraglottic carc-inoma and to compare results of treatment in patients with T3 transglottic carcinoma with T3 pure supraglottic carcinoma. Materials and Method:postoperative radiation therapy from 1990 to 20. Neck dissection was performed in 27 patients and 24 patients received postoperative radiation therapy. Results:The 3-year overall survival rate was 81.6%. The 3-year overall survival rate of T3 pure supraglottic carcinoma and T3 transglottic carcinoma were 91.7% and 73.2%, respectively (p<0.05). The univariate analysis revealed a prognostic significance for vocal cord fixation and statistical trend to age, dyspnea, clinical and patholo-(p<0.2). T3 transglotic carcinoma was signifi-cantly correlated with vocal cord fixation. Conclusion:Surgery or surgery with postoperative radiation therapy provides acceptable rates of cancer control and survival rate for patients with T3 supraglottic carcinoma. Transglottic involvement and vocal cord fixation shown by the fiberoptic laryngoscopy were significant prognostic factors. T3 transglottic cancer needs more aggressive management. (Korean J Otolaryngol 2002;45:506-10)
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성문상부암에서 N0 경부에 대한 예방적 방사선치료의 효과
나홍식(Hong Shik Na),이창행(Chang Haeng Lee),임기정(Gi Jung Im),권순영(Soon Young Kwon),최종욱(Jong Ouck Choi),정광윤(Kwang Yoon Jung) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2
Background and Objectives: Supraglottic cancer have a great tendency to spread cervical lymph nodes and lymph node metastasis is a well known prognostic factor. However the treatment for N0 neck in supraglottic cancer is still controversial. Materials and Methods: We retrospectively analyzed our neck management of supraglottic cancer patients who present with cN0 contralateral neck from 1989 through 1997. 36 patients were eligible for analysis. The primary site was surgically removed and the neck was managed by elective neck irradiation (ENI), elective neck dissection (END), or therapeutic neck dissection (TND) with postoperative radiation therapy (PORT). Results: Our results revealed that 18 of 36 patients have clinically negative neck, another 18 patients have clinically positive neck (N1-3). In clinically negative group, 12 of 18 patients were received ENI and there was 1 failure in contralateral neck area. Remaining 6 patients were received END with PORT and there was no failure. In clinically positive neck group, 3 of 18 patients were received ipsilateral TND and an additional contralateral END with PORT. Remaining 15 patients who were received TND with PORT, developed 3 neck failure. Conclusion: ENI or ipsilateral or bilateral END can be done in the cN0 neck of supraglottic cancer however ipsilateral TND and contralateral END with PORT is reasonable for the cN(+) neck.
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