文化컨텐츠産業 發展을 위한 政策方向 硏究

이중엽(Lee Jung Yeup) 한국디지털디자인학회 2003 디지털디자인학연구 Vol.6 No.-

모바일엔터프라이즈 서비스 발전동향과 정책적 시사점

이중엽(Lee Joong-Yeup),권형진(Kwon Hyung-Jin),정지범(Jung Ji-Bum) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.6

동결 해동한 포배 이식에 있어서 동결시기가 임신결과에 미치는 영향

김현정,김충현,이중엽,권재희,황도영,김기철,Kim, Hyun-Jung,Kim, Chung-Hyon,Lee, Joong-Yeup,Kwon, Jae-Hee,Hwang, Do-Yeong,Kim, Ki-Chul 대한생식의학회 2010 Clinical and Experimental Reproductive Medicine Vol.37 No.1

목 적: 배양 환경과 동결 기술이 발달함에 따라 동결 포배의 해동-이식의 빈도가 증가하고 있으며, 신선 주기와 마찬가지로 해동-이식 주기에서도 질 좋은 배아를 선별하는 것은 임신 성공 여부를 결정하는 아주 중요한 과제이다. 본 연구는 동결 당시 포배로의 발달 속도가 임신 결과에 미치는 영향을 알아보기 위하여, 수정 후 5일 및 6일째 동결한 포배의 해동-이식 후 임신율을 비교 분석하였다. 연구방법: 2006년 1월부터 12월까지 5일째 또는 6일째 동결한 포배를 해동하여 2007년 6월까지 융해 이식한 87명, 93주기를 대상으로 하였다. 동결법은 ethylene glycol과 DMSO를 이용한 유리화 동결법을 이용하였으며, 팽창 포배는 인위적인 수축을 시행 후 동결하였다. 해동 과정은 이식 전날 시행하여 15~18시간 배양액에서 배양 후 재팽창 여부를 확인하였다. 결 과: 5일째 동결한 포배를 해동-이식한 52주기와 6일째 동결한 포배를 해동-이식한 41주기에서 환자의 나이, 이식한 배아의 수, 해동 배아의 생존율 등 임신 결과에 영향을 미칠만한 요인들의 차이는 없었다. 그러나 생화학적 임신율, 임상적 임신율, 진행 임신율, 착상율 등은 5일째 동결한 포배를 해동-이식한 주기에서 높게 나타났다. 결 론: 5일째 동결한 포배를 해동-이식했을 때의 임신율은 6일째 동결한 포배를 해동-이식했을 때의 임신율보다 2배 이상 높았으며, 이는 신선 주기와 마찬가지로 해동-이식 주기에서도 동결 전 배아의 발달 속도의 차이를 임신 성공 예측의 중요한 지표로 사용할 수 있음을 시사한다. Objectives: Likewise fresh cycle, it is also important to select right blastocysts for transfer in purpose of improving the pregnancy and implantation rates in frozen-thawed embryo transfer (ET) cycles. To investigate the relationship between the developmental velocity at the time of cryopreservation and pregnancy rates, we compared pregnancy rates between the day 5 cryopreservation group and the day 6 cryopreservation group. Methods: Transfers of frozen-thawed blastocysts which had been cryopreserved by vitrification on day 5 or day 6 were performed between January 2006 and June 2007. Ethylene glycol, DMSO, and pull and cut straws were used for vitrification and artificial shrinkage was done in expanded blastocysts. Thawing was performed on the day before transfer and thawed blastocysts were cultured in for 15~18 hrs in Quinn's blastocyct media. Blastocyst survival was assessed before transfer and post-thaw survival was defined as >50% of cells remaining intact and blastocoele re-expansion by the time of transfer. Results: Transfers of thawed blastocyst had been cryopreserved on day 5 were 52 cycles and 41 transfer cycles were cryopreserved on day 6. Patient characteristics, the number of transferred embryos and the survival rate of thawed blastocysts were not different in each cryopreservation day. But the biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and implantation rate were significantly high in transfer of frozen-thawed blastocyst which were cryopreserved on day 5. Conclusions: The clinical pregnancy and implantation rate of day-5 blastocyst showed significantly higher than those of day-6 blastocyst in frozen-ET cycles. This result indicated that developmental rate of blastocyst at cryopreservation time in frozen-thawed cycle is discriminative marker of pregnancy outcome as like in fresh cycle.

포배기 배아의 동결보존후 이식시 자궁내막 준비를 위한 자연주기법과 외인성 호르몬투여법의 비교 연구

박혜은 ( Hye Eun Park ),이정렬 ( Jung Ryeol Lee ),최영식 ( Young Sik Choi ),이중엽 ( Joong Yeup Lee ),정재훈 ( Jae Hoon Jung ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),김기철 ( Ki Chul Kim ),민응 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.4

Objective: The objective of this study was to compare the outcomes of cryopreserved-thawed blastocyst transfer (CT-BT) in natural or programmed cycles using exogenous steroid hormones. Methods: A total of 221 CT-BT cycles were included and divided into two groups according to endometrial preparation protocols. In natural cycle group (n=116), monitoring was performed by transvaginal ultrasonography to detect ovulation. In programmed cycle group (n=105), oral estradiol valerate, 6 mg/day, was started on the third day of the menstrual cycle and administered continuously, and progesterone in oil 100 mg i.m. daily injection was started on cycle day 15. CT-BTs were performed on five days after ovulation in natural cycles and five days after the initiation of progesterone administration in programmed cycles. Pregnancy rates, implantation rates, and other clinical characteristics of the two groups were compared. Results: Clinical characteristics of study subjects did not differ between the two groups. Post-thaw survival rates, number of transferred blastocysts, and number of good-quality blastocysts were not different. There were no statistically significant differences in implantation rates (21.1% vs. 19.4%), clinical pregnancy rates (36.2% vs. 36.2%), and ongoing pregnancy rates (28.4% vs. 27.6%) between the two groups. Conclusions: No statistically significant differences were found in pregnancy rates and implantation rates between the two protocols. Our results suggest that both protocols are equally effective for endometrial preparation in CT-BT cycles.

폐경이행기 여성에서 폐경 예측지표로서 혈중 anti-Mullerian hormone, follicle-stimulating hormone, 초음파상의 동난포 개수 및 임상적 증상들의 유용성 평가

김선미 ( Sun Mie Kim ),김석현 ( Seok Hyun Kim ),이정렬 ( Jung Ryeol Lee ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),이중엽 ( Joong Yeup Lee ),김기철 ( Ki Chul Kim ),황도영 ( Yeong Hwang ),김정구 ( Jung Gu Kim ),문신용 ( S 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2

Objective: To assess the efficiency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical findings as predictive markers of menopause in late reproductive-aged Korean women. Methods: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. Results: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed significantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were significantly associated with the occurrence of menopause. Conclusion: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.

圓住針狀形 Fin 群에서의 强制對流 熱傳達 特性

鄭仁基,金重燁,李判錫 嶺南大學校 工業技術硏究所 1981 연구보고 Vol.9 No.2

Experiments on forced convection of air for the cylindrical pin-fin arrays were performed for a Reynolds number range of 210.5 to 1052.6. The effect of interfin spacing, ?//d×??/d=2×2 and 3×3, was investigated for in-line and staggered pin-fin arrays. Data were also obtained for changing of the pin-fin height. The experimental data were utilized to compare with the values calculated for the tube banks. The results were as follows; 1) The average heat transfer coefficients for staggered array are higher than those for in-line array. Those for both pin-fin arrays more affected are more affected in Reynolds number than tube banks, and lower pin-fin arrays. 2)The heat-transfer rate for staggered array in the same interfin spacing are higher than those for in-line array, and the heat transferred increases as the spacing of pin-fins becomes narrow. 3)The fin efficiency of pin-fin arrays decreases as the Reynolds number increase, and this situation is more in lower pin-fin arrays. The fin efficiency for in-line arrays is higher than that for staggered arrays.