정맥용 면역글로불린 투여 후 발생한 무균성 수막염 3례

이준호,송은경,이진아,김남희,김동호,박기원,최은화,이환종,Lee, Joon Ho,Song, Eun Kyoung,Lee, Jin A,Kim, Nam Hee,Kim, Dong Ho,Park, Ki Won,Choi, Eun Hwa,Lee, Hoan Jong 대한소아감염학회 2005 Pediatric Infection and Vaccine Vol.12 No.2

IVIG 투여에 의해 무균성 수막염은 그 기전이 밝혀지지 않았으나 IVIG 투여와 관련된 신경학적 부작용 중 가장 중한 합병증의 하나이다. 저자들은 서울대학교 어린이병원에서 2003년부터 2004년까지 3명의 환아에서 확인된 IVIG 투여와 관련된 무균성 수막염 4례를 경험하여 보고하였다. 3명의 환아는 ITP, 가와사키병, 중증 근무력증으로 기저질환은 각각 상이하였으나 기저질환에 대한 치료를 위해 모두 고용량의 IVIG를 투여받았으며, IVIG를 투여받은 후 1~2일 이내에 심한 두통과 뇌막자극 징후를 보였다. 척수액 소견상 백혈구 수는 $100/{\mu}L$ 미만에서부터 $1,000/{\mu}L$ 이상까지 다양하였으나 주로 다핵구로 구성된 척수액 백혈구 분포를 보였고(66~98%), 세균 배양검사와 장바이러스 배양과 PCR 검사에서 음성 결과를 보였다. 3명의 환아 모두 수막염 발생 2일 후까지는 증상이 호전되었으며, 후유증 및 장애가 없었다. Intravenous immune globulin(IVIG) is widely used for immune thrombocytopenic purpura (ITP), Kawasaki disease and other autoimmune neuromuscular disease. Aseptic meningitis was one of the most serious neurologic complications reported following the use of IVIG. We experienced 4 episodes of aseptic meningitis associated with IVIG usage in 3 patients from 2003 to 2004. Underlying disease of each patients was ITP, Kawasaki disease and myathenia gravis and all of them received high dose IVIG treatment for their underlying disease. Within a days, they started to complain severe headache and diagnosed meningitis by cerebrospinal fluid analysis. Cerebrospinal fluid leukocyte counts varied from 92 to over a thound per microliter with dominance of polymorphonuclear leukocytes. Microbiologic studies revealed no organisms. All of them were free from headache within 2 days and did not suffer any neurological sequelae.

2001년 경상북도에서 발생한 콜레라 유행에 관한 역학조사

이준호,이관,김준철,이상원,고운영,양병국,이종구,김문식,임현술,Lee, Jun-Ho,Lee, Kwan,Kim, Jun-Chul,Lee, Sang-Won,Go, Un-Yeong,Yang, Byung-Kuk,Lee, Jong-Koo,Kim, Moon-Sik,Lim, Hyun-Sul 대한예방의학회 2002 예방의학회지 Vol.35 No.4

Objectives : This study was carried out to investigate the cause, magnitude and transmission route of the cholera outbreak in 2001 Methods : The study population were those persons who ingested foods at the restaurant, were confirmed as cholera patients, had symptoms of diarrhea and sewed as workers at the restaurant. A questionnaire survey and microbiological examinations on the microbes isolated from rectal swabs were conducted. Of the cases, 316 food histories were surveyed by an analysis of the restaurant menu. Results : There were 139 confirmed cases of cholera reported in Korea in 2001. Of these, 104 were related to the restaurant. By region, Gyeongsangbuk-do had the highest incidence with 91 cases. Of these 91 cases, 74 had ingested foods at the restaurant, 2 were employees and 3 were secondary infection cases within the families. The results of the odds ratio analysis of the 316 persons having ingested foods at the restaurant were as follows: sandwiches 5.07 (95% CI, 1.85-14.59), soybean curd 2.45 (95% CI, 1.09-5.56), noodles 2.34 (95% CI, 1.24-4.42), steamed squid 2.01 (95% CI, 1.17-3.47) and vinegared rice 1.82 (95%, CI, 1.08-3.09). It was certain the restaurant in question was the cause of the 2001 outbreak. Conclusions : We suspected that more than one restaurant employee contaminated foods served at the restaurant. In addition, eating raw fishes purchased at the Pohang Fisheries infected the employees of the restaurant. There is a possibility that these raw fishes were themselves contaminated by cholera bacilli in the sea.

Experimental Evaluation of Q-Parameterization Control for the Imbalance Compensation of Magnetic Bearing Syatem

이준호,김현기,이정석,이기서,Lee, Jun-Ho,Kim, Hyeon-Gi,Lee, Jeong-Seok,Lee, Gi-Seo 대한전기학회 1999 전기학회논문지A Vol.48 No.3

This paper utilizes the method of Q-parameterization control to design a controller which solves the problem of imbalance in magnetic bearing systems. There are two methods to solve this problem using feedback controal. The first method is to compensate for the imbalance forces by generating opposing forces on the bearing surface (imbalance compensation). The second method is to make the rotor rotate around its axis of inertia (automatic balancing);in this case no imbalance forces will be generated. In this paper we deal with only imbalance compensation. The free parameter of the Q-parameterization controller is chosen such that these goals are achieved. After the introduction of a model of the magnetic bearing system, we explain the Q-parameterization controller design of the magnetic bearing system with emphasis on the rejection of sinusoidal disturbance for imbalance compensation design. The design objectives are formulated as a linear equations in the controller free paramete Q. Finally, simulation and experimental results are presented and showed the robustness and effectiveness of the proposed controllers.

A 37Ch Visible Adaptive Optics System for Wavefront Compensation

이준호,Byung Tae Choi,Eung Cheol Kang,Hae Seog Kho,Ho Jung Cheon,Jae Il Lee,Joon Won Kim,Kyung Muk Lee,Sung Jin Kim,Young Cheol Lee,Young Il Cho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

A visible adaptive system was developed to compensate for phase distortions of a visible (He-Ne) laser. The visible adaptive optics (AO) system consists of 5 subsystems: a Shack-Hartmann wavefront sensor, a deformable membrane mirror of 15 mm with 37 actuators, a high-speed tip/tilt mirror of 20 mm, a position sensor and a control & display unit. The lab-developed Shack-Hartmann sensor was experimentally shown to have a measurement accuracy of better than RMS /50 at 0.6328 μm over the maximum phase distortion that the deformable mirror could generate, i.e., approximately /4. The adaptive optics system operated the deformable mirror at 10 Hz and the tip/tilt mirror at 30 Hz, which were, respectively, closed by the Shack-Hartmann sensor and the position sensor. The closed adaptive optics system was demonstrated to compensate for time-varying wavefront aberrations of PV (Peak-to-Valley) 1.2 μm with a time frequency of 1.4 Hz. The residual RMS wavefront error was shown to be smaller than 0.014 μm, i.e., /45 at 0.6328 μm.

국내 도시하천에 대한 식수허가지도의 적용성 검토

이준호,윤세의,Lee, Joon-Ho,Yoon, Sei-Eui 한국방재학회 2005 한국방재학회논문집 Vol.5 No.3

도시하천의 관리와 계획에 있어 식수에 따른 수리학적 특성의 변화는 명확히 분석되어야 한다. 본 연구에서는 도시하천의 식수기준을 분석하고, 도시하천의 고수부지내 식수가 가능한 지역을 표시한 식수허가지도 제작 방법을 검토하였다. 또한 식수에 따른 수리학적 영향을 준2차원 수치모형, HEC-RAS, FESWMS 모형을 활용하여 분석하였다 중랑천의 장안교부터 군자교까지의 구간을 대상으로 선정하여 100년 빈도 홍수량에 식수허가지도를 제작한 결과, 교목의 식수시에는 하천의 우안에 $0.5{\sim}1$본/ha 정도의 식수가 가능하였으며, 관목의 경우에는 좌안 및 우안의 중요수방구간을 제외한 지역에 식재가 가능하였다. 또한 관목의 식재에 따른 수리학적 영향은 약 12cm 정도의 수위상승 결과를 나타내었다. 따라서 대상구간에 식수에 따른 수위 상승은 적은 것으로 판단되므로 식수허가지도에 따라 식수가 가능할 것으로 판단된다. In order to design and manage the urban streams, the change of hydraulic characteristics by vegetation must be analyzed clearly. Planting criteria of vegetation in a urban stream were investigated and the design method of vegetation permission map was analyzed in this study. In addition, variations of water level due to vegetation are calculated by quasi two dimensional numerical model, HEC-RAS model and FESWMS model. Joongrang stream(Gunja bridge${\sim}$Jangan bridge reach) was selected as the case study stream. According to the criteria of vegetation, it is decided that vegetation density was $0.5{\sim}1.0$ tree/ha for selected tall tree in right floodplain and shrubs can be planted in the right and left floodplain area except the important hydraulic structures site. The selected shrubs planting simulations with three models show that water level in selected floodplain area increase approximately 12cm for the 100 year return period flood. The applicability of vegetation permission map in Korean urban stream was analyzed in this paper.

하천복원을 위한 하천평가기법의 적용성 연구

이준호,강태호,성영두,윤세의,Lee. Joon-Ho,Kang. Tae-Ho,Sung. Young-Du,Yoon. Sei-Eei 한국방재학회 2003 한국방재학회논문집 Vol.3 No.4

본 연구의 목적은 하천 관리자들에게 하천의 자연성 증진의 중요성을 이해시키고, 하천을 자연스러운 상태로 되돌리는 과정에서 하천이 처한 상황에 대한 진단과 처방을 위한 하천자연도 평가 방법을 개발하는 것이다. 본 연구에서는 하천의 자연도평가와 그 적용성의 확인을 위해 수로의 발달, 종방향, 횡방향, 하상구조, 저수로변 구조, 하천주변, 수질 등 7가지 자연도 평가기법의 항목을 제안하였다. 자연도평가를 위해 복하천을 대상하천으로 선정하였다. 복하천에서 자연도지수는 <TEX>$2.2{\sim}3.8$</TEX>정도였고, 평균지수는 3.1로 대부분이 3등급을 나타내었다. 7개 지수 중에서 횡단면이 가장 높은 등급이었고, 수로의 발달이 가장 낮은 등급이었다. 본 연구에서는 하천의 자연도 등급을 통해 하천의 자연성을 파악할 수 있었으며, 복원해야 할 하천의 선택과 훼손된 하천의 복원구간 및 방법을 결정할 수 있었다. The purpose of this study was to develop a new method for evaluation of stream naturalness in order to promote stream managers` understanding on importance of improving stream naturalness, and in order to appraise and prescribe for streams effectively in the process of ecological restoration of stream corridors. In order to analyze the evaluation method of stream naturalness and its applicability to streams, stream naturalness index(SNI) which has seven factors such as channel development, longitudinal profile, lateral section, stream bed structure, low flow channel structure, stream surroundings and water quality was suggested in this paper. For case studies, Bokha stream was selected for the evaluation of stream naturalness. At the Bokha stream, the scores of SNI factors were in range of <TEX>$2.2{\sim}3.8$</TEX>, and the average of SNI was 3.1, and the most frequent grade of SNI factors was grade 3. Among the 7 factors, the best was lateral section, and the worst was channel development. In this study, SNI grade can represent the characteristics of stream naturalness well and select the streams which will be restored, and can also decide the segment and the method of restoration for deteriorated streams.

방위각을 이용한 신호원 위치 추정 알고리즘의 성능 비교

이준호,김민철,조성우,진용기,이동근,Lee, Joon-Ho,Kim, Min-Cheol,Cho, Seong-Woo,Jin, Yong-Ki,Lee, Dong-Keun 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.4

In this paper, we present the performance of the LOB(line of bearing) - based emitter localization algorithm. The linear LSE(least-squared error) algorithm, nonlinear LSE algorithm and Stansfield algorithm are considered. In addition, we focus on the performance improvement of the weighted estimation compared with the unweighted estimation. Each estimation algorithm is briefly introduced, and the performance of the algorithm is illustrated using the numerical results.

링크식 격발기구 설계에 관한 연구

이준호,여운주,최의중,Lee, Joon-Ho,Yeo, Woon-Joo,Choe, Eui-Jung 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.3

In the traditional percussion locks of small arms, a firing pin is struck by a hammer rotating on a single center of rotation, which makes the percussion mechanism simple and reliable. In order to strike the firing pin by the hammer, however, the firing pin should be located within the radius of rotation of the hammer. As the distance between the striking point of the firing pin and the center of rotation of the hammer becomes longer, the radius of rotation of the hammer should also be increased, which results in the increase of the volume and weight of the small arms because the hammer needs the more space for its operation inside of the small arms. In this paper, a link type percussion lock was newly proposed in order to overcome the limitation of designing small arms when using traditional percussion locks, as mentioned above. The link type percussion lock was modeled by using multi-body dynamics software and designed to satisfy the requirements such as striking force level of the hammer exerting on the firing pin enough to detonate the percussion cap of ammunitions and the safety on the accidental drop. It was applied to the newly developed dual-barrel weapon system, in which the weight and overall length are important design factors, and verified by durability test and drop test on the ground.

Vibrio vulnificus에 의한 감염성 근염의 자기공명영상소견: 증례 보고

이준호,나재범,Lee, Jun-Ho,Na, Jae-Beom 대한영상의학회 2003 대한영상의학회지 Vol.48 No.3

비브리오 패혈증은 간질환의 병력이 있는 해안가 주민에서 해산물을 섭취한 후 발생하며, 대부분 피부, 피하지방과 근막으로 염증이 생기며 하지로부터 몸통과 상지 쪽으로 퍼져나가며 패혈증으로 사망하게 된다.비브리오 패혈증의 감염성 근염은 매우 드물고, 자기공명영상 소견은 보고된 적이 없다. 저자들은 Vibrio vulnificus에 의한 양측하지의 감염성 근염 증례를 1예 경험하였기에 자기공명영상 소견과 함께 보고하고자 한다. Vibrio vulnificus infection is a fatal disease occurring after the consumption of seafood in patients with underlying liver disease. Inflammation of the skin, subcutanous fat and fascia disseminates from the lower extremity to the trunk and upper extremity Infectious myositis caused by vibrio vulnificus is rare, and its MR imaging findings have not been reported. We report these in a case of infectious myositis caused by vibrio vulnificus involving both lower extremities.

전기비저항 탐사 기반 TBM 터널 굴진면 전방 위험 지반 예측을 위한 실내 토조실험 연구

이준호,강민규,이효범,최항석,Lee, JunHo,Kang, Minkyu,Lee, Hyobum,Choi, Hangseok 한국터널지하공간학회 2021 한국터널지하공간학회논문집 Vol.23 No.6

터널 굴진면 전방 위험 지반 예측은 TBM (Tunnel Boring Machine) 굴진 성능 및 안정성 확보에 필수적이다. 국내·외에서 굴진면 전방 예측을 위한 전기비저항 탐사법에 대한 연구가 다수 이루어졌으나, TBM 터널 굴진을 고려한 전기비저항 탐사의 실내 실험 모사가 어렵기에 이와 관련된 실험 연구가 매우 부족한 실정이다. 따라서 본 연구에서는 전기비저항 탐사법의 터널 전방 위험 지반 예측 적용성을 분석하기 위한 TBM 굴진을 모사한 실내 축소 모형 실험을 수행하였다. 터널 굴진면 전방의 단층 파쇄대, 해수 침수대, 토사-암반 변화구간, 암반-토사 변화구간을 축소 모사하여, 굴진 중 전기비저항의 변화를 측정하였다. 본 연구에서는 실제 시공 조건을 재현하기 위해 화강암 블록을 사용하여 모형 지반을 모사하였다. 실험 결과, 터널이 굴진하면서 단층 파쇄대에 근접할수록 전기비저항이 감소하였으며, 해수 침수대도 동일한 경향을 보였으나, 단층 파쇄대와 비교하여 측정된 전기비저항이 크게 감소하였다. 토사-암반 변화구간의 경우, 전기비저항이 상대적으로 높은 암반에 터널 굴진면이 다가갈수록 전기비저항이 증가하는 양상을 보였다. 이와 반대로 암반-토사 변화구간의 경우, 전기비저항이 낮은 토사 지반에 굴진면이 근접할수록 전기비저항이 감소하였다. 실험 결과를 통해 전기비저항 탐사 굴진면 전방 위험 지반(단층 파쇄대, 해수 침수대, 토사-암반 변화구간, 암반-토사 변화구간)의 예측이 가능하다고 판단된다. Predicting hazardous ground conditions ahead of a TBM (Tunnel Boring Machine) tunnel face is essential for efficient and stable TBM advance. Although there have been several studies on the electrical resistivity survey method for TBM tunnelling, sufficient experimental data considering TBM advance were not established yet. Therefore, in this study, the laboratory-scale model experiments for simulating TBM excavation were carried out to analyze the applicability of an electrical resistivity survey for predicting hazardous ground conditions ahead of a TBM tunnel face. The trend of electrical resistivity during TBM advance was experimentally evaluated under various hazardous ground conditions (fault zone, seawater intruded zone, soil to rock transition zone, and rock to soil transition zone) ahead of a tunnel face. In the course of the experiments, a scale-down rock ground was provided using granite blocks to simulate the rock TBM tunnelling. Based on the experimental data, the electrical resistivity tends to decrease as the tunnel approaches the fault zone. While the seawater intruded zone follows a similar trend with the fault zone, the resistivity value of the seawater intrude zone decreased significantly compared to that of the fault zone. In case of the soil-to-rock transition zone, the electrical resistivity increases as the TBM approaches the rock with relatively high electrical resistivity. Conversely, in case of the rock-to-soil transition zone, the opposite trend was observed. That is, electrical resistivity decreases as the tunnel face approaches the rock with relatively low electrical resistivity. The experiment results represent that hazardous ground conditions (fault zone, seawater intruded zone, soil-to-rock transition zone, rock-to-soil transition zone) can be efficiently predicted by utilizing an electrical resistivity survey during TBM tunnelling.