Coronoid view: 주두 골절의 평가를 위한 새로운 방사선 촬영법

이주엽,송주현,이한용,김동엽 대한견주관절의학회 2007 대한견주관절학회 학술대회논문집 Vol.2007 No.5

헬리코박터 파일로리와 심혈관 질환

이주엽 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.1

Since its discovery, Helicobacter pylori (H. pylori) has played a central role in the pathogenesis of gastroduodenal diseases. Additionally, there have been many studies that demonstrated the role of H. pylori infection in extragastric diseases. Many research studies have confirmed an indirect association between the prevalence of H. pylori infection and the occurrence of cardiovascular diseases (CVDs); however, the results are still conflicting. Most studies found that the involvement of H. pylori in this process was related to the chronic inflammation. This inflammation may facilitate the development of CVD-related atherosclerotic pathologies such as endothelial damage and chronic activation of coagulation cascade, etc. Furthermore, H. pylori infection is known to be associated with other vascular diseases such as cerebrovascular diseases and cardiac arrhythmias, especially atrial fibrillation. This review summarized the literature on the association of cardiovascular manifestations and H. pylori infection and provided information about the pathogenesis of this association.

화학물질 관리에 대한 이해 54 - 공정안전관리(PSM) 제도의 현황 및 개선방안

이주엽,Lee, Ju-Yeop 대한산업보건협회 2015 산업보건 Vol.332 No.-

New Oral Anticoagulants를 복용하는 환자들에서 위장관 출혈의 위험인자

이주엽 대한상부위장관ㆍ헬리코박터학회 2018 Korean Journal of Helicobacter Upper Gastrointesti Vol.18 No.4

New oral anticoagulants (NOACs) are now widely used for the prevention and treatment of venous thrombosis, and for the prevention of stroke and systemic embolism in patients with atrial fibrillation. As compared with warfarin, NOACs have the advantage of rapid onset of action and less drug interaction. However, they carry a higher risk of gastrointestinal (GI) bleeding than warfarin. The risk of GI bleeding in patients using NOACs varies according to the type and dose of the drug. By contrast, apixaban and edoxaban are reported to carry similar risks as warfarin, and the risks with dabigatran and rivaroxaban are higher than that with warfarin. In patients using NOACs, old age, impaired renal function, impaired liver function, concurrent use of antiplatelet agents, and nonsteroidal anti-inflammatory drugs are considered major risk factors of GI bleeding, and gastroprotective agents such as histamine-2 receptor antagonist and proton pump inhibitor have preventive effects. To prevent GI bleeding associated with NOACs, the characteristics of each NOAC and the risk factors of bleeding should be recognized. (Korean J Helicobacter Up Gastrointest Res 2018;18: 219-224)

안드로이드 애플리케이션 환경에서 CFI 우회 공격기법 연구

이주엽,최형기 한국정보보호학회 2020 정보보호학회논문지 Vol.30 No.5

CFI(Control Flow Integrity) is a mitigation mechanism that protects programs by verifying control flows. IFCC(IndirectFunction Call Checks) and SCS(Shadow Call Stack), CFI supported by LLVM Clang compiler, were introduced to protectapplications in Android. IFCC protects function calls and SCS protects function returns. In this paper, we propose attacks tobypass CFI on the application environment with IFCC and SCS. Even if IFCC and SCS were applied to user applications,it was confirmed that there were many code segments not protected by IFCC and SCS in the application memory. Weexecute code in CFI unprotected segments to construct 1) bypassing IFCC to call a protected function, 2) modulating returnaddress via SCS bypass. We identify code segments not protected by IFCC and SCS in Android10 QP1A. 191005.007.A3. We also implement proof-of-concept exploits to demonstrate that modulation of control flow is possible in an environmentwhere IFCC and SCS are applied. CFI(Control Flow Integrity)는 제어 흐름을 검증해 프로그램을 보호하는 기법이다. 안드로이드 환경에서 애플리케이션 보호를 위해 LLVM Clang 컴파일러가 지원하는 CFI 기법인 IFCC(Indirect Function CallChecks)와 SCS(Shadow Call Stack)이 도입되었다. IFCC가 함수 호출, SCS이 함수 복귀 시 제어 흐름을 보호한다. 본 논문에서는 IFCC, SCS을 적용한 애플리케이션 환경에서 CFI 우회 공격기법을 제안한다. 사용자 애플리케이션에 IFCC, SCS을 적용하여도 애플리케이션 메모리 내 IFCC, SCS으로 보호되지 않은 코드 영역이 다수존재하는 것을 확인하였다. 해당 코드 영역에서 공격을 위한 코드를 실행해 1) IFCC로 보호된 함수 우회 호출 기법, 2) SCS 우회를 통한 복귀 주소 변조 기법을 구성한다. 안드로이드10 QP1A. 191005.007.A3 환경에서IFCC, SCS으로 보호되지 않은 코드 영역을 식별하고 개념 증명(proof-of-concept) 공격을 구현해 IFCC, SCS이 적용된 환경에서 제어 흐름 변조가 가능함을 보인다.

Skin layer 코팅에 사용되는 Mono Methyl Ether 기반 수성 폴리우레탄의 제조 및 물리적 성질

이주엽,Lee, Joo-Youb 한국응용과학기술학회 2019 한국응용과학기술학회지 Vol.36 No.2

본 연구에서는 가죽 스킨층에 코팅용으로 사용할 수용성 폴리우레탄의 합성을 위해 polyrupopylene mono methyl ether (PM)를 기반으로 폴리 에테르 폴리올인 폴리 프로필렌 글리콜과 이소포론 디 이소시아네이트 (isophorone diisocyanate, IPDI)를 합성 하였다. 예비 중합체의 합성 후, 점도 상승을 억제하기 위해 $40^{\circ}C$에서 1M, 2M, 3M 및 4M으로 PM을 첨가하고 중화 반응 및 사슬연장 반응을 수행하여 폴리 우레탄 시료를 준비 하였다. 준비된 시료의 인장강도와 연신율, 접착강도를 측정한 결과로 인장강도는 PM 이 1M 일 때 2.109 kgf/mm2, 4M 에서 1.721kgf/mm2, 연신율은 PM이 1M일 때 496%, 4M 에서 522%, 접착력은 PM이 1M 일 때 1.114 kgf/cm, 4M 에서 0.99 kgf/cm 로 확인 되었다. In this study, polyether polyol polypropylene glycol and isophorone diisocyanate (IPDI) were synthesized based on polyrupopylene mono methyl eher (PM) for the synthesis of water - soluble polyurethane for coating on leather skin layer. After synthesis of prepolymer, PM was added at $40^{\circ}C$ to 1M, 2M, 3M, and 4M to inhibit the viscosity rise, and neutralization reaction and chain extension reaction were carried out to prepare polyurethane samples. According to the measurement results of the tensile strength, elongation and adhesive strength of the prepared sample, the tensile strength was 2.109 kgf / mm2 for PM 1M, 1.721kgf / mm2 for 4M, elongation was 496% for PM 1M, 522% for 4M, adhesion was 1.114 kgf / cm for PM 1M and 0.99 kgf / cm for 4M.

Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice

이주엽,김나영,최윤정,남령희,이선민,함민희,서지형,최윤진,이혜승,이동호 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.1

Background: The aim of this study was to evaluate the anti-inflammatory and anti-tumorigenic effect of açai berry after chronic Helicobacter felis colonization in the stomachs of C57BL/6 mice. Methods: A total of 57 four-week-old female C57BL/6 mice (18 control mice and 39 experimental mice) were used. The mice were administered orogastrically with vehicle only or vehicle containing H. felis, 5 times every other day. After inoculation of H. felis, mice were fed either a standard or an açai-containing diet and then sacrificed at 4, 24, and 52 weeks. The infection status and degree of inflammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), TNF-α, and interleukin-1β (IL-1β) were measured by ELISA. Results: At 24 weeks after inoculation, mucosal atrophy and mucous metaplasia appeared in all infected mice. At 52 weeks after inoculation, dysplastic change was noted in 10%, 25%, and 50% of mice in the H. felis-control, H. felis-açai 5%, and H. felis-açai 10% groups, respectively. The neutrophil, monocyte, atrophy, and metaplasia grades of infected mice showed no significant difference among the H. felis-infected groups. H. felis-infected mice fed with açai berry showed no significant difference compared with H. felis-infected control mice in gastric mucosal MPO, TNF-α, and IL-1β levels. Conclusions: H. felis that colonized the stomachs of C57BL/6 mice provoked inflammation, and induced mucosal atrophy, metaplasia, and dysplasia. However, açai berry did not effectively prohibit the gastric carcinogenesis which was induced by chronic H. felis infection.

Histologic Findings and Inflammatory Reactions After Long-term Colonization of Helicobacter felis in C57BL/6 Mice

이주엽,김나영,최윤정,남령희,최윤진,권용환,Kichul Yoon,서지형,Seon Min Lee,이혜승,이동호 대한암예방학회 2014 Journal of cancer prevention Vol.19 No.3

Background: The Helicobacter felis (H. felis) mouse model has been developed for the research regarding pathogenesis of chronic gastritis and gastric cancer. The aim of this study was to investigate long-term H. felis colonization in the stomachs of C57BL/6 mice and subsequent histologic findings and inflammatory reactions including pro-inflammatory cytokines. Methods: Twenty-three female C57BL/6 mice at 4 weeks of age were gavaged with H. felis, and 13 control mice served as vehicle only. The mice were sacrificed at 4, 24, and 52 weeks after inoculation. The infection status and degree of inflammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-α), and interleukin-1beta (IL-1β) were measured by ELISA. Results: The overall infection rate was 100%, as determined by the culture and histology. At 4, 24, and 52 weeks, the neutrophil and monocyte scores were significantly higher in infected mice than in control mice. At 24 weeks after inoculation, most of the infected mice showed mucosal atrophy with or without metaplasia, and a few showed focal dysplasia. Adenocarcinoma was observed in one mouse at 52 week post-infection. Gastric mucosal MPO and IL-1 levels were significantly higher in infected mice than those in control mice at 24 and 52 weeks. However, the expression of gastric mucosal TNF-α was not significantly different between the infected and control mice at any time-point. Conclusions: Long-term H. felis-infection in C57BL/6 mice provoked a severe inflammatory reaction and it progressed into atrophy, metaplasia, dysplasia and cancer. IL-1β might play an important role in the inflammatory response of mice to Helicobacter species.

경험주의적 문헌학과 이론적 해석학의 충돌: 2000년대 베케트 연구에서 발생한 펠드만-다우드 논쟁을 중심으로

이주엽 새한영어영문학회 2019 새한영어영문학 Vol.61 No.3

This study casts light on the conflict between empirical philology and theoretical criticism in the history of Western literary studies by concentrating on the Feldman-Dowd dispute which took place in Beckett Studies in the 2000s. Feldman argues that the best way to increase scholarly knowledge about Beckett is via verifiable empirical evidence which allows a falsification process. Dowd questions the legitimacy of the direct application of scientific concept of falsification to literary studies; Feldman’s narrow view of authorship; and the supposed objectivity of empirical science. He also raises concern about the restrictions that his methodological standardization might incur for critical hermeneutics. Feldman’s dogmatic position is further troubled by Uhlmann’s observation of natural limits in the interpretative methods of falsifiability related to empirical evidence. Van Hulle offers a reconciliation between philological empiricism and theoretical interpretation by classifying between exogenetics and endogenetics, as does Wittgenstein by distinguishing between cause and reason.

폴리인산 암모늄과 HMDI 기반으로 제조된 수분산 폴리우레탄 수지의 물리적 특성 연구

이주엽 한국응용과학기술학회 2020 한국응용과학기술학회지 Vol.37 No.6

본 연구에서는 폴리인산암모늄 인산염과 HMDI로 합성된 수분산 폴리우레탄수지의 물리적 특성을 필름 시료와 피혁(Full-Grain) 표면에 코팅을 하여 물리적 특성 변화를 연구하였다. 내용제성은 모든 시료에서 변확 없음을 확인 할수 있었으며, 인장강도의 경우 폴리인산암모늄이 가장 많이 함유된 DPU-AP3(1.887 kg f /㎟)가 가장 낮은 물성을 보였다. 연실율은 폴리인산암모늄 많이 함유된 시료가 548%로 측정되었다. 내마모성은 폴리인산암모늄이 많이 함유된 시료가 548 ㎎.loss로 측정되어 폴리인산 암모늄과 수분산 폴리우레탄의 블랜딩된 수지의 물성변화가 확인되었다. In this study, the physical properties of water-dispersible polyurethane resins synthesized with polyammonium phosphate and HMDI were studied by coating film samples and full-grain surfaces. Solvent resistance was found to be unchanged in all samples, and in terms of tensile strength, DPU-AP3 (1.887 kgf/㎟) containing the most ammonium polyphosphate showed the lowest physical properties. The elongation rate was measured as 54 8% in the sample containing a large amount of ammonium polyphosphate. Abrasion resistance was measured as 548 mg.loss of a sample containing a lot of ammonium polyphosphate, and it was confirmed that the physical properties of the blended resin of ammonium polyphosphate and water-dispersible polyurethane were changed.