골종양 절제후 방사선 조사한 자가골을 이용한 재건술

이종석,전대근,김석준,이수용,양현석,Lee, Jong-Seok,Jeon, Dae-Geun,Kim, Sug-Jun,Lee, Soo-Yong,Yang, Hyun-Seok 대한근골격종양학회 1997 대한골관절종양학회지 Vol.3 No.1

PURPOSE : For the reconstruction of large bone defect after tumor resection, it is possible to reuse the bone involved by tumor with some treatment to it. Several bone-reusing methods have been reported such as autoclaving, low-heat treatment(pasteurization) and intraoperative radiotherapy. We have used extracorporeally radiated autogenous bone graft for reconstruction after tumor resection, and analyzed the periods for junctional union, functional results and complications to know the indications of this method. METHODS : From Dec. 1993 to Sept. 1995, nine patients had taken autogenous bone graft with extracorporeal irradiation. Eight cases were osteosarcoma and 1 giant cell tumor. The graft sites were 5 in femur, 3 proximal tibia and 1 femur and tibia. Stage 3 was 1 case(GCT), Stage IIB 3 and Stage IIIB 5. After wide resection, surrounding soft tissue and intramedullary and extramedullary portion of the tumor were removed. Radiation was done in 5000cGy to the resected bone. Ender nails and bone cement were inserted and filled into the medulla to prevent fracture. RESULTS : Average follow-up period was 12.3(4 to 21) months. Average junctional union period in simple X-ray was 6.5 months in 4 cases. Average functional score following Enneking's criteria was 19(12-27). Complications were as follows ; condylar fractures and femur neck fracture in 4 cases, subluxation of the knee joint 3 and infection 1. Although local recurrence was detected in 1 case, the site of recurrence was not in the radiated bone but surrounding soft tissue. At final follow-up, no recurrence was found in one case(GCT), CDF 2, AWD 2, DOD 3, and died of chemotherapy related sepsis 1. CONCLUSIONS : Extracorporeally radiated bone autograft is considered to be a method for reconstruction of the large bone defect made by tumor resection, especially in the reconstruction around the joint.

트랜치 에미터 전극을 이용한 수직형 NPI 트랜치 게이트 IGBT의 전기적 특성 향상 연구

이종석,강이구,성만영,Lee Jong-Seok,Kang Ey-Goo,Sung Man-Young 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.10

In this paper, Trench emitter electrode IGBT structure is proposed and studied numerically using the device simulator, MEDICI. The breakdown voltage, on-state voltage drop, latch up current density and turn-off time of the proposed structure are compared with those of the conventional trench gate IGBT(TIGBT) structures. Enhancement of the breakdown voltage by 19 % is obtained in the proposed structure due to dispersion of electric field at the edge of the bottom trench gate by trench emitter electrode. In addition, the on-state voltage drop and the latch up current density are improved by 25 %, 16 % respectively. However increase of turn-off time in proposed structures are negligible.

수집 ㆍ 선별업체 지원 확대해야...

이종석,Lee, Jong-Seok 한국자원재생재활용연합회 2004 재활용회보 Vol.2 No.-

Au 나노입자가 함침된 Poly (3, 4-ethylenedioxythiphene) 고분자 박막의 전기변색 특성연구

이종석,구경회,박형호,Lee, Jong-Seok,Koo, Kyoung-Hoe,Park, Hyung-Ho 한국재료학회 2009 한국재료학회지 Vol.19 No.10

The electrochromic properties of Au nanoparticles (NPs) incorporating poly (3, 4-ethylenedioxythiphene) (PEDOT) film were investigated. Trisodium citrate was used for stabilizing Au NPs to control the size. The capping molecules of the Au nanoparticles were exchanged from citrate to 2-mercaptoethanol (2-ME). Water was removed by centrifuge and Au NPs were redispersed in methanol (MeOH). Finally, we obtained ca. 11.7 nm diameter of Au NPs. The effects of 0.15 at% of Au NPs incorporation on the optical, electrical, and eletrochromic properties of PEDOT films were investigated. The electrical property and switching speed of Au/PEDOT film was slightly improved over that of PEDOT film because Au NPs play a hopping site role and affect packing density of the PEDOT chain. Through the ultra violet-visible spectra of PEDOT and Au/PEDOT films at -0.7 V (vs Ag/AgCl), blue shift of maximum absorption peak was observed from PEDOT (585.4 nm) to Au/PEDOT (572.2 nm) due to a shortening of conjugated length of PEDOT. The Au NPs interfered with the degree of conjugation and the maximum absorption peak was shifted to shorter wavelength.

출판저널 칼럼

이종석,Lee, Jong-Seok 대한출판문화협회 1987 출판저널 Vol.8 No.-

악교정 수술후 혈액학적 변화에 대한 연구

이종석,고승오,정길중,임대호,백진아,신효근,Lee, Jong-Seok,Ko, Seung-O,Jeong, Kil-Jung,Leem, Dae-Ho,Baek, Jin-A,Shin, Hyo-Keun 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.2

Moderns have desire likely to be further good-looking concomitant with a qulitative advancement of the life. Orthognathic surgery for the correction of dentofacial deformities is a common elective procedure. It's possible to occur many complication during the operations and especially, an excessive bleeding of those may be fatal and so a tranfusion is performing for the prevention and management of that. The most notable of these for reduction of blood loss is the utilization of induced hypotensive anesthetic technique to reduce the mean arterial pressure between 55 and 60 mmHb. Another method for dealing with blood loss following orthognathic surgery is the transfusion of blood obtained as an autologous tranfusion or from banked blood. Some of the disadvantage of banked blood are overcome with the use of predeposited autologous transfusion. But currently, surgeons try so that even autologous transfusion may not transfuse the patients. We made a comparative study of hematologic change and transfusion requirement based on a series of 200 patients who had an orthognathic surgical procedure at Chonbuk National University during the period 2001-2005. This study is to make a comparative analysis of an post-operative hematologic (Hemoglobin, Hematocrit, Red blood cell) change and duration of the procedure under induced hypotensive anesthesia in healthy orthognathic patients.

산학협력실 운용을 통한 수자원 연구과제 개발

이종석,한재명,김민정,Lee, Jong-Seok,Han, Jae-Myeong,Kim, Min-Jeong 한국수자원학회 2008 물과 미래(한국수자원학회지) Vol.41 No.2

PIN 다이오드 - PNP 트랜지스터 결합모델에 의한 1,700 V급 NPT 트랜치 IGBT의 해석에 관한 연구

이종석,경신수,강이구,성만영,Lee, Jong-Seok,Kyoung, Sin-Su,Kang, Ey-Goo,Sung, Man-Young 한국전기전자재료학회 2008 전기전자재료학회논문지 Vol.21 No.10

This paper presents a comprehensive mathematical analysis and simulation of trench IGBT with the help of PIN-PNP combinational model. Since trench IGBT is characteristically influenced by PIN diode, it may be almost impossible to analyze the trench IGBT using PNP-MOS modeling methods, even PIN-MOS techniques which neglect the hole current components coming into p-base region. A new PIN-PNP complementary cooperational model is developed in order to make up the drawbacks of existing models. It would allow us to make qualitative analysis as well as simulation about switching and on-state characteristics of 1,700 V trench IGBT. Moreover, if we improve the PIN diode effects through the optimization of trench structure, trench IGBT is expected to be one of the most promising devices in the not only high-voltage but also high speed switching device field.

생분해성 고형물에 흡착시켜 실험동물에 국소 투여한 홀미움- 166-키토산 복합체의 투여량, 기간 및 부위에 따른 조직의 괴사 정도와 양상

이종석,전대근,조완형,이수용,오정문,김진욱,Lee, Jong-Seok,Jeon, Dae-Geun,Cho, Wan-Hyung,Lee, Soo-Yong,Oh, Jung-Moon,Kim, Jin-Wook 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

목적: Holmium-166은 류마티스성 관절염 및 간암 치료에서 이미 임상적으로 사용이 보고된 방사성 동위원소이다. 본 연구는 holmium-166-chitosan 복합체를 외과적으로 생체에 투입하여 임상에 적용 가능한 방법을 연구하고, 투여량과 기간, 투여 부위에 따른 조직학적 반응 정도를 정성 및 정량 분석하여 임상적용의 기초로 활용하는 것이다. 재료 및 방법: Absorbable gelatin sponge에 액체상태의 holmium-166-chitosan 복합체를 50 ${\mu}l}$ 도포하여 고형제로 만들었다. 최종 삽입전에 caliberator로 측정한 방사선량은 약 1.5 mCi였다. Wistar종 흰쥐에 외과적 시술을 통하여 대퇴근육 내부와, 그리고 대퇴골에 접하게 holmium-166-chitosan 복합체가 부착된 gelatin sponge를 삽입 후 봉합하였다. 대퇴 근육내와 대퇴골에 투여한 후 2주, 4주, 6주에 육안 및 현미경 소견하에서 조직 괴사의 깊이, 조직 변화의 양상, 삽입된 gelatin sponge의 변화 등을 관찰하였다. 결과: 2주후의 현미경 소견상 holmium-166과의 접촉면에서는 정상 근육세포의 모양을 찾아 볼 수 없을 만큼 심한 괴사 소견을 보였고 근육세포의 퇴화 및 재생, 근육간 부종, 염증세포의 침윤 소견을 보였으며 유발된 괴사의 깊이는 평균 3.3 mm 였다. 대퇴골에서는 holmium-166과의 접촉면에 있는 골피질은 골소강내 골세포의 소실이 관찰되었고 골수강내의 골수 세포도 파괴되고 섬유화 또는 염증성 반응을 보였다. 괴사의 깊이는 평균 2.9 mm 였다. 4주 때 근육에서는 석회화와 보다 심해진 섬유화 소견이 추가 되었고 괴사의 깊이는 평균 3.3 mm 였다. 골조직에서도 골수강의 섬유화가 더 증가되었고 괴사의 깊이는 평균 3.3 mm였다. 경과 관찰 6주 군에는 연부 조직의 위축과 섬유화의 증가, 육아조직의 형성, 염증 소견의 소실 등이 관찰되었다. 결론: Holmium-166-chitosan 복합체를 생체 흡수 가능한 gelatin sponge에 부착시킨 후 실험동물에 삽입한 결과, 실험동물의 사망을 유발하지도 않았으며 상처의 괴사, 염증, 감염 등의 부작용이 전혀 없어, 생체에 외과적 적용이 가능하였다. 유발된 조직 괴사의 범위는 약 3 mm로 미리 예측한 정도에 근접하는 것으로 악성종양 치료에 임상적 적용이 가능할 것으로 생각한다. Purpose: The aim of this study was to find out a clinically appliable method to insert a biodegradable solid material containing holmium-166-chitosan complex into the surgical field, and to evaluate the histological changes in the normal tissues after ${\beta}$ -ray irradiation from holmium-166 according to the dose, period and type of tissues. Materials and Methods: 3.0 mCi, 50 ${\mu}l$ of the liquid state $^{166}$Ho-chitosan complex was attached to the absorbable gelatin sponge. The radiation activity measured by dose caliberator was 1.5 mCi. These $^{166}$Ho-chitosan complex containing absorbable gelatin sponges were inserted into the thigh muscles and over the femur bones of the Wistar rats. The cases were evaluated at 2 weeks after insertion, and 4, 6 weeks with respect to the histological changes of the soft tissues and bone, the depth of the tissue necrosis, and the changes of the $^{166}$Ho-chitosan complex containing absorbable gelatin sponges. Results: At 2 weeks, the muscles showed coagulation necrosis, degenerating myocytes, regenerating myocytes, intermuscular edema, and inflammatory cells. The necrosis depth was 3.3 mm. In the bones, there was no osteocyte in the lacuna of cortex (empty lacuna), marrow fibrosis, inflammation. The necrosis depth was 2.9 mm. At 4 weeks, in the muscle, calcification and increased fibrosis with necrosis depth by 3.3 mm were the additional findings. In the bone, marrow fibrosis with necrosis depth by 3.3 mm were detected. At 6 weeks, soft tissue shrinkage, increased fibrosis and granulation tissue formation, and nearly resolving inflammatory reaction were the findings. Conclusion: The local application of the $^{166}$Ho-chitosan complex attached to biodegradable gelatin material with surgery in the laboratory animals resulted in no mortality and morbidity, and satisfactory tissue necrosis. Holmium-166 can be applied to the treatment of the malignant tumor patients.

온수양생을 이용한 초고강도 콘크리트의 강도 조기 추정에 관한 실험적 연구

이종석,명로언,공민호,백민수,이영도,정상진,Lee, Jong-Seok,Myung, Ro-Oun,Gong, Min-Ho,Paik, Min-Su,Lee, Young-Do,Jung, Sang-Jin 대한건축학회 2011 대한건축학회논문집 Vol.27 No.5

In this study, prediction of later-age compressive strength of ultra-high strength concrete, based on the accelerated strength of concrete cured in hot water was investigated. Comparing other acceleration method, hot water curing method is relatively easy and intuitive to use in the real construction site. The amount of time for evaluation of the concrete strength using the hot water curing method in KS and JIS is too long to predict the strength of the ultra-high strength concrete that are used in the tall building structure. For that reason, curing temperature of 40, 50, $60^{\circ}C$ 3 levels were examined to shorten the amount of time for the evaluation of the strength. When curing in warm water, different strength characteristics are verified from the experiment. In case of F3 substituting 30% fly ash in combination, because of the curing temperature sensitivity of fly ash, differences of strength expression velocity was verified according to the curing temperature at the same age. In case of B4 substituting 40% ground granulated blast furnace slag, there were no big strength expression velocity differences of the specimen cured in 3 different level of curing temperature(40, 50, $60^{\circ}C$). The results show reliable accuracy by regression relation between 28day strength cured by standard curing method and accelerated strength of concrete cured in warm water.(y=1x-0.0002 $R^2$=0.9866) As a result, the feasibility of 3day-prediction was confirmed using warm water curing method with accelerated strength of concrete cured for three days in warm water.