국어교육과 학교도서관

이종록,Lee, Jong-Rok 한국도서관협회 1966 圖協月報 Vol.7 No.1

현호색(玄胡索)과 초초현호색(醋炒玄胡索)의 여드름균에 대한 항균효과 비교

이종록,박숙자,김영우,조일제,변성희,김상찬,Lee, Jong-Rok,Park, Sook-Jahr,Kim, Young-Woo,Cho, Il-Je,Byun, Sung-Hui,Kim, Sang-Chan 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.3

Objectives : Corydalis tuber has been used for promoting blood circulation and for relieving pain in Oriental medicine. In the present study, we focused on the antimicrobial activity of Corydalis tuber and compared its antimicrobial activity with the processed Corydalis tuber. Methods : Processing of Corydalis tuber was accomplished by immersing in 5% of acetic acid for 12 h and then by roasting at $250^{\circ}C$ for indicated time periods(0-30 min). Minimum inhibitory concentration(MIC) and the zone of growth inhibition were determined against Propionibacterium acnes(P. acnes). Results : The methanolic extracts of Corydalis tuber showed potent antimicrobial effect(MIC 62.5 ${\mu}g/ml$). Its alkaloidal component, dehydrocorydaline, also exhibited antibacterial activity(MIC 25.0 ${\mu}g/ml$). After processing of Corydalis tuber, its inhibitory effect on the growth of P. acnes was significantly enhanced compared with that of unprocessed Corydalis tuber. Furthermore, elevated content of dehydrocorydaline was found in the processed than the unprocessed Corydalis tuber. However, the different roasting minutes effected on antimicrobial activity. The best roasting time of Corydalis tuber was 10 min, while roasting for the time above 15 min resulted in diminishing antimicrobial activity. Thus, it was concluded that the standardized processing condition of Corydalis tuber should be established to obtain enhanced antimicrobial(P. acnes) activity. Conclusion : For antimicrobial effect against P. acnes, the best processing condition of Corydalis tuber is immersing in 5% of acetic acid for 12 h and by roasting at $250^{\circ}C$ for 10 min.

감초 지표성분 분석법 확립 및 liquiritigenin의 함량 증대를 위한 감초의 수치에 관한 연구

이종록,조미정,박상미,김상찬,박숙자,Lee, Jong-Rok,Jo, Mi-Jeong,Park, Sang-Mi,Kim, Sang-Chan,Park, Sook-Jahr 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Objective : Licorice has been used for treating digestive disorder and also recommended as a detoxification agent. Liquiritigenin, a component of licorice, has been reported to have various biological activities. In this study, we aimed to establish the analytical method for liquiritigenin content in licorice and the processing method for the enhancement of liquiritigenin content in licorice. Methods : Processing was accomplished by roasting licorice at $250^{\circ}C$ for indicated time periods (5-20 min). Analysis of liquiritigrnin from roasted licorice was conducted using UPLC(Ultra Performance Liquid Chromatography). Results : We established UPLC method for the analysis of liquiritigenin using water : acetonitrile gradient as mobile phase. Furthermore, we standardized the processing condition of licorice to enhance liquiritigenin content using UPLC method. Processing of licorice was accomplished by roasting at $250^{\circ}C$ for indicated time periods (5-20 min) and by pretreating with 50% of acetic acid or 30% ethanol for 24 h. By roasting licorice, the liquiritigenin contents in the licorice were increased. The best roasting time of licorice was 6 min, while roasting for the time above 8 min resulted in diminishing liquiritigenin contents. Moreover, pretreatment with 50% of acetic acid or 30% ethanol picked up liquiritigenin contents in roasted licorice. Conclusion : The adequate processing condition of licorice for the enhancement of liquiritigenin contents was obtained by pretreating licorice with 50% of acetic acid or 30% ethanol for 24 h and then by roasting at $250^{\circ}C$ for 6 min.

쑥갓 잎에서 터펜노이드계 화합물의 분리 및 동정

이경동 ( Kyung Bong Lee ),하태정 ( Tae Joung Ha ),이병원 ( Byong Won Lee ),이종록 ( Jong Rok Lee ),이준 ( Jun Lee ),황선우 ( Sun Woo Hwang ),조동령 ( Dong Young Cho ),남상해 ( Sang Hae Nam ),양민석 ( Min Suk Yang ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1

Three terpenoids were isolated from the leaves of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. The structure of compounds 1, 2, and 3, using various spectroscopic data, were identified as to be terpenoid derivatives of dihydrotulipinolide, loliolide, and 5α, 8α-peroxyergosterol, respectively. The presence of these 3 is the first time reported in this plant. The cytotoxic activity of 5α, 8α-peroxyergosterol showed strong activities against human cancer cell lines such as A549, PC-3, and HCT 116.

지칭개에서 분리한 Hemistepsin A와 B의 비듬균에 대한 항균효과

이종록(Jong Rok Lee),정대화(Dae Hwa Jung),박문기(Moon Ki Park) 한국생물공학회 2013 KSBB Journal Vol.28 No.2

There are a large number of bioactive sesquiterpene lactones from compositae plants including Hemistepita lyrata Bunge. In the present study, we purified two sesquiterpene lactones, Hemistepsin A and B, from H. lyrata and evaluated their antimicrobial activities against Malassezia obutusa. Chromatographic separation was used for the preparation of Hemistepsin A and B, and the identity of these compounds was confirmed by NMR. Strong inhibition of growth of M. obutusa was obtained with all doses of Hemistepsin A tested. Moreover, antifungal activity of Hemistepsin A occurred in a dose-dependent manner. Hemistepsin B also showed potent antifungal activity at the dose of 800 μm/disc. From these results, it was suggested that Hemistepsin A and B be beneficial for the preparation of the useful agent for treating scalp diseases occurred by dandruff-causing Malassezia species.

대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구

이종록 ( Jong Rok Lee ),김영우 ( Young Woo Kim ),변성희 ( Sung Hui Byun ),김상찬 ( Sang Chan Kim ),박숙자 ( Sook Jahr Park ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.5

Objectives: Fermentation of herbs has been known to be helpful in improving the immune systems and protecting body against disease. The present study was conducted to evaluate anti-inflammatory effects of the fermentation extracts (FE) consisting of soybean, red ginseng and Citrus Unshiu Peel in lipopolysaccharide (LPS) -activated Raw264.7 cells. Methods: FE were prepared by the fermentation with Bacillus Subtilis and then by extraction with ethanol (95%; prepared by the fermentation process). Cell viability was measured by MTT assay. Nitric oxide (NO) production was measured in culture media by Griess assay. The expression of nuclear factor (NF)-κB and inhibitory kappa B alpha (IκBα) was determined by Western blot. Results: LPS-induced production of NO and PGE2 was dose-dependently decreased by the treatment of FE in Raw264.7 cells. These suppressive effects of FE on NO and PGE2 production were related to the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. FE inhibited LPS-induced production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-1β in a dose-dependent manner. Furthermore, FE inhibited the NF-κB signaling pathway through the prevention of LPS-induced degradation of IκBα in cytosol and the nuclear translocation of NF-κB. Conclusions: These findings suggest that FE could have anti-inflammatory effects on LPS-induced inflammatory responses in macrophages.

산화스트레스를 유발한 위 상피세포에서 수치 치자의 세포 보호 효과

이종록 ( Jong Rok Lee ),김상찬 ( Sang Chan Kim ),박숙자 ( Sook Jahr Park ) 대한본초학회 2023 大韓本草學會誌 Vol.38 No.1

Objective : Gardeniae Fructus (GF) has bitter and cold nature. Thus, it has been traditionally prescribed in processed form roasted with ginger juice for patients with a weak stomach. This study investigated the effects of processed GF in tert-butyl hydroperoxide (tBHP)-treated gastric epithelial cells. Methods : Processed GF was made by applying 40% ginger juice or 10% ethanol for 24 h and then roasting at 150℃ for 5 minutes. Apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Mitochondrial membrane potential (MMP) was monitored by flow cytometry using the membrane permeable fluorescent dye Rh123. Protein expression was measured by Western blot analysis. Results : Cell viability was reduced by tBHP and restored by ethanol extract of GF (GFE). In the TUNEL assay, it was found that cell death by tBHP was due to apoptosis, and GFE had an anti-apoptotic effect. Processed GF roasted with ginger juice showed the best anti-apoptotic effect. Processed GF also inhibited MMP loss and restored tBHPinduced changes in expression levels of apoptosis-related proteins. Increased ROS production and GSH depletion after tBHP treatment were significantly reduced by processed GF. In addition, tBHP-induced activation of mitogen-activated protein kinase (MAPK) was inhibited by processed GF. Conclusion : These results demonstrate that the processed GF is able to protect gastric epithelial cells from oxidative stress-induced cell death with antiapoptotic and antioxidant activity. In addition, it shows that the processing of GF, which have been traditionally used for gastrointestinal protection, partially have scientific validity.

예언과 시뮬라크르: 시뮬라크르 개념으로 살펴보는 에스겔서 40-48장의 환상

이종록(Lee Jong-Lock) 한신대학교 신학사상연구소 2011 신학사상 Vol.0 No.154

이 논문은 에스겔서 40-48장에 나오는 환상의 방식과 성격을 새로운 각도에서 살핌으로써 그 문학유형을 명확하게 규정하는데 목적을 두는데, 이를 위해서 ‘시뮬레이션’(simulation)과 ‘시뮬라크르’(simulacre) 개념을 사용할 것이다. 그리고 이러한 작업을 통해서, 에스겔서 40-48장에 나오는 환상(vision)이 환상(fantasy)이며, 그래서 에스겔서 40-48장이 “환상문학”임을 밝힐 것이다. 에스겔서 40-48장은 구약성서에서 대표적인 환상문학이다. 여러 학자들이 본문의 장르를 규명하기 위해서 많은 노력을 기울였는데, 지금까지의 에스겔서 40-48장에 대한 연구는 말할 것도 없고 현재의 연구 작업들도 우리가 사는 디지털 시대를 염두에 두지 않았다는 한계를 보인다. 그리고 환상문학 연구에 필요한 철학과 예술에 대한 현대적 논의를 전혀 고려하지 않았다. 지금까지 학자들은 에스겔서 40-48장을 단순하게 “환상보고” 양식이라고 명명함으로써, 이 본문이 다른 환상 본문들과 비교할 때 보여주는 현격한 차이에 주목하지 않았으며, 이 본문에 명확하게 그리고 독특하게 나타나는 환상체험방식과 내용 자체를 깊이 연구하지 않았다. 에스겔서 40-48장이 보여주는 본질적이고 고유한 차이를 드러내고 그것을 보다 정확하게 명명하기 위해서는, 시뮬레이션과 시뮬라크르라는 개념을 통해서 본문을 새롭게 살펴보아야 한다. 에스겔서 40-48장은 가상공간에서 시뮬레이션을 한다는 점에서 “하나님의 이상”(마르오트 엘로힘)을 언급하는 다른 두 본문, 즉 에스겔서 1장, 그리고 8-11장과 매우 상이하며, 이 본문이 묘사하는 환상체험은 기원도 없고 재현물도 없이, 즉 지시대상이 없이 발생하는 순수 사건으로서의 온전한 시뮬라크르이다. 그리고 본문은 환상 속의 환상, 즉 시뮬라크르의 시뮬라크르라를 보인다. 또한 에스겔서 40-48장이 갖는 이런 독특성으로 인해, 본문의 환상(vision)은 환상(fantasy)이며, 그래서 본문은 다른 환상 본문들과는 구별되는 환상문학(fantasy)이기도 하다. 이런 점에서, 이 연구는 앞으로 예언과 환상문학을 연계하는 새로운 연구영역을 확보했다는 데 의미를 갖는다. This paper takes aim at studying the mode and the character of Ezekiel 40-48 from the new angle and defining the literary genre of it. In order to do so, I will adapt the concept of simulation and simulacre. So I will come clean on the fact that the vision of Ezekiel 40-48 is the fantasy, and that Ezekiel 40-48 is the literature of fantasy. Ezekiel 40-48 is the representative literature of vision in the Old Testament. Many scholars have tried to find out the genre of that text, but the studies on that text until now have not considered the fact that our days are very digital. And most of scholars have not considered the discussion about the modern philosophy and the modern art which is useful for the study of the literature of vision. By this time, scholars have named the genre of Ezekiel 40-48 as “vision report.”They have not paid attention to the wide difference between that text and the other vision reports and they have not studied the mode of vision experience and the content of our text thoroughly. In order to expose the essential and proper difference that Ezekiel 40-48 shows and to name it correctly, we should study newly our text by the concept of simulation and simulacre. By the fact that our text shows the skill of simulation in the virtual space, it is very different from Chapter 1 and 8-11 of the Book of Ezekiel that mention about the vision of God. The vision experience that our text describes has no origin and representation of it. Therefore, it is a simulacre as the occurring pure event without referent in reality. And in our text, we can find also the vision of vision, that is, simulacre of simulacre. And because of such peculiarity of Ezekiel 40-48, vision of our text is fantasy, and our text itself is the literature of fantasy that is distinguished from the other texts of vision in the Old Testament. From this view point, this study is very meaningful for securing the new research realm.

高句麗의 東沃沮 정벌과 樂浪郡

이종록(Lee Jong Rok) 한국고대학회 2016 先史와 古代 Vol.49 No.-

『三國志』 등의 사료에 따르면 高句麗가 농사에 적합하지 않은 땅에 위치하여 늘 식량공급 등의 경제적인 문제에 직면해 있었다고 한다. 때문에 고구려는 정복전쟁을 통해 경제적 문제를 해결하려고 하였고, 1세기경의 동옥저 정벌은 그 전쟁의 하나였을 것으로 추정된다. 그런데 동옥저 정벌에 있어서 고구려에게 최대의 장애물은 이미 이 지역에 지배권을 확보하고 있었던 樂浪郡 세력이었다. 따라서 大武神王代 고구려는 정복전쟁은 그 목표가 바로 이들 낙랑군 세력이었을 것으로 본 연구에서는 파악하였다. 고구려는 呑列縣을 비롯한 낙랑군의 縣을 공략하여 동옥저지역의 교통로를 확보하였으며, 그 여파는 낙랑군이 하여금 영동 7현을 방기하는 이유 중 하나가 되었다. 그리고 동옥저에서 군현세력이사라지고 토착 小國들이 서로 相爭하는 기회를 틈타, 고구려는본격적으로 이 지역에 대한 정벌을 추진하였다. 그러나 동옥저에서는 여전히 親漢勢力이자 군의 지배질서를 수용하던 집단이 잔존하고 있었다. 이들은 영동 7현의 방기 이후에도 여전히 樂浪郡의 소속으로써 그 정체성을 보유하고 있던 집단이던 것이다. 따라서 고구려는 이들 친한 세력을 제압하는 방식으로 동옥저 정벌을 수행하였으며, 이것이 사료상에서 樂浪國 이라는 나라와의 전쟁이라는 것이다. 그리고 이후 이들은 낙랑군을 대신하여 토착세력들(渠帥)에게 지배자의 입장에서 조세의 貢納을 받으며 경제적 욕구를 충족했을 것으로 분석하였다. According to historical records such as Sanguozhi(三國志; the Records of the Three Kingdoms), Koguryǒ(高句麗) had constantly suffered economic problems because of its inadequate earth for agriculture. Thus, Koguryǒ used militaristic methods as a solution to their scarcity of provisions, and the invasion into East Okchŏ(東沃沮; Dongokchŏ) was an exemplary case for this mechanism in the first century. The biggest obstacle to Koguryǒ s conquest of East Okchŏ was Chinese Lelang(樂浪) Commandery, which had already secured control over the region using local pro-Chinese groups in East Okchŏ. Consequently, the consistent purpose of King Taemusin(大武神王) s campaigns was to defeat these groups. Koguryǒ attacked Lelang s counties such as Tunlie(呑列縣) to acquire a route to East Okchŏ, and the invasion s aftereffect severed the commandery s direct reign over the region. After Chinese commanderies recession from East Okchŏ, small countries(小國) started quarrels with each other, a situation which allowed Koguryǒ to easily infiltrate into this region. Arguably, the leaders of small countries were the local pro-Chinese groups who kept their identity as a part of Chinese commandery even after the commandery s recession. It was natural that Koguryǒ s aggression targeted at these groups remained in East Okchŏ, since they were potential threats to Koguryǒ s rule over the region. This invasion was described as a war with a kingdom named Lelang(樂浪國; Nangnangguk), supposedly one of the local countries under a pro-Chinese leader. After successfu occupation of East Okchŏ, Koguryǒ adopted a similar method of Chinese commanderies control over the region, as it was the most effect way to satisfy their economic needs.

사회적 기업에 대한 구약성서적 근거: 성전 건축과 성벽 재건에 관한 본문들을 중심으로

이종록(Lee, Jong-Locke) 한신대학교 신학사상연구소 2014 신학사상 Vol.0 No.165

이 글은 사회적 기업에 대한 구약성서적 근거를 제시하는 데 목적을 둔다. 구약성서에서 사회적 기업에 대한 직접적인 언급을 찾아볼 수는 없지만, 사회적 기업과 연관 지을 수 있는 개념들을 발견하는 것은 어렵지 않다는 전제 하에 연구를 시작했다. 사회적 기업과 연결하기 위해서 선언적이거나 신학적인 본문보다는 실제적인 사역을 다루는 본문을 선택하고자 했고, 솔로몬 시대에 이루어진 성전 건축과 느헤미야 시대에 이루어진 성벽 재건 공사를 연구대상으로 택했다. 성전 재건 공사에 대해서는 역대기서를 본문으로 삼았고, 성벽 재건 공사에 대해서는 느헤미야서를 본문으로 삼았다. 성전 건축과 성벽 재건 사역이 그 성격상 일자리 창출이라는 점에서 사회적 기업과 연관 지을 수 있음을 확인했는데, 그것들을 보다 더 구체적으로 사회적 기업과 연관 짓기 위해 사회적 기업이 갖춰야 할 세 가지 요건, 즉 사회적 기업의 생산성, 사회적 기업의 재정적 지속가능성 그리고 사회적 기업의 민주성에 근거해서 살펴보았다. 그 결과 이러한 세 가지 요인이 성전 건축과 성벽 재건 사역에서 명확하게 나타나는 것을 확인했다. 이런 점에서 성전 건축과 성벽 재건 사역을 사회적 기업에 대한 구약성서적 근거를 제공하는 대표적인 사례로 제시한다. The purpose of this paper is to find the basic concepts of the social enterprise from the Old Testament. It is true we can not find the direct utterance to the social enterprise in the Old Testament, but it is not difficult to find the ideas and the concepts of the social enterprise from the Old Testament. I choose two texts from the Old Testament as the object of our study, that is, the building of the temple under the reign of Solomon and the rebuilding of the walls of Jerusalem under the reign of Nehemiah. The building of the temple gave the opportunity to find a job to the people of Israel and Tyre. Therefore we call it the government or the royal family initiated project of employment. The rebuilding of the walls was started by the persuasion of Nehemiah and achieved by the people in Judah. They divided the whole range of the walls into many parts and allotted it to each of them. Each of them rebuilt his allotment on his responsibility. Therefore it was the co-initiated project of the Government and the Civil to give the opportunity of employment. The social enterprise should achieve three requisites, the productivity of the social enterprise, the financial sustainable possibility of the social enterprise, and the democratic system of the social enterprise. We can find these three requisites in the building project of the temple and the rebuilding project of the walls of Jerusalem. The building of the temple and the rebuilding of the walls were started by the attempt of the social integration to make their community solid. It seems to satisfy the condition of the productivity of the social enterprise. The royal family and the leading people participated voluntarily and actively in the building temple project and the rebuilding wall project by donation for construction costs and offering of labor power until the completion. It seems to satisfy the condition of the financial sustainable possibility of the social enterprise. And all sorts and conditions of