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L - 3 [ 123I ] iodo - α - methyltyrosine 합성과 9L Glioma 이식 백서 분포조사
임상무(Sang Moo Lim),이종두(Jong Doo Lee),서용섭(Yong Sup Suh),전권수(Kwon Soo Chun),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),양승대(Seung Dae Yang),임종석(Jong Seok Lim),박현(Hyon Park),윤용기(Yong Ki Yun) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A L-3[123I]iodo-methyltyrosine([123I] IMT) was synthesized by electrophilic radio-iodination using chloramine-T and Iodobead in phosphate buffered solution. And the biodistribution was examined in 9L glioma bearing rats. The radiosynthesis of [123I] IMT with iodobead was simpler and higher in radiochemical yield(88%) than the method using chloramine-T(83%) as radioiodinating reagent. The highest yield was obtained from the reaction using 1 piece of Iodobead, 200μg α- methyltyrosine in 100μl phosphate-buffered solution (pH 5.5) and the reaction was completed in 7min. 24hours after the injection, the biodistribution in 9L glioma transplanted rats revealed the in vivo deiodination, the excretion via kidney, and 3 times higher uptake in the tumor than normal brain. These results suggest the promising clinical use of [123I]IMT in the various ious malignancies.
123I , 99mTc 사람 비특이 IgG 및 67Ga - Citrate의 실험동물에서 염증병소 섭취율의 비교
오옥두(Ok Doo Awh),임상무(Sang Moo Lim),이종두(Jong Doo Lee),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),서용섭(Yong Sup Seo) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
N/A 123I has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, 123I has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling condition of 123I and 99mTc to nonspecific human polyclonal IgG, and comparing these with 67Ga-citrate in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added 123I by chloramine T method. Human polyclonal nonspecific IgG was labeled with 99mTc-gluconate after activation with β-mercaptoethanol. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, 123I nonspecific IgG had higher uptake than 99mTc-IgG or 67Ga-citrate. There was no significant difference in absecess uptake of 123I-IgG among 24, 72, 120 hours abscess age. Further clinical researches with 123I-nonspecific IgG, and other immunoscintigraphies using 123I are expected.
< 51Cr > Cr ( III )-EDTA 착물 합성 및 < 51Cr > Cr ( III )-EDTA 주사후 두경부 방사능 계측에 의한 사구체 여과율 측정
양승대,임상무,전권수,서용섭,윤용기,박현,우광선,정위섭,오옥두,이종두 ( Seung Dae Yang,Sang Moo Lim,Kwon Soo Chun,Yong Sup Suh,Yong Ki Yoon,Hyun Park,Kwang Sun Woo,Wi Sup Chung,Jong Doo Lee,Ok Doo Oh ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
The purpose of this study is to evaluate the clinical application of the no carrier added[Cr] Cr(UI) EDTA complexes, produced at Korea Cancer Center Hospital. The [Cr]Cr(lll) EDTA complexes, useful for measurement of GFR were prepared at room temperature in the presence of bicarbonate catalysts. The radiochemical purity of[Cr]Cr (Iil) EDTA was over 99% by paper electrophoresis. The time activity curves were obtained by counting the blood samples from 5 volunteers and counting the head and neck regions with whole body counter after inject#ion of the Cr EBTA, respectively, After the nonlinear regression, the area under curve was obtained. The plasma clearance of the Cr-EDTA was calculated with injected dose/AUC. The clearance rate calculated with the head and neck countmg data was in good agreement with t,he result from the plasma sample radioactivity at, 1-3 hrs after injection. From this result, the counting of head and neck region and the nonlinear regression by 2-compartment model could be applied for the measurement of the clearance rate. Using MIRD system, the absorbed radiation dose was calculated by residence time x S. The absorbed whole body radiation dose was negligibly small.
최창운,양승대,우광선,정위섭,임수정,서용섭,전권수,안순혁,이종두,홍성운,임상무 ( Chang Woon Choi,Seung Dae Yang,Kwang Sun Woo,Wee Sup Chung,Soo Jung Lim,Yong Sup Suh,Kwon Soo Chun,Soon Hyuk Ahn,Jong Doo Lee,Sung Soon Hong,Sang Moo Lim 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.3
Purpose : The aim of this sutdy was to evaluate the feasibility of 3-[131I]Iodo-O-methyl-L-a-methyltyrosine ([131I]OMINT) as an agent for tumor image. Materlals and Methods: After synthesis of 4-O-methyl-L-a-methyltyrosine (OMAMT), OMAMT was labeled with 131I using Iodogen method. In viro cellular uptake study was performed using 9 L gliosarcoma cells at various time points upto 4 hr. The biodistribution (five rats implanted with the 9 L gliosarcoma cells per group) was evaluated at 30 min, 2 hr, 24 hr after iv injection of 3.7 MBq [131I]OMIMT or L-3-[131I]iodo-a-methyltyrosine ([131I]IMT). Gamma camera images were obtained at 30min, 2 hr, and 24 hr. Results : [131I]OMINT uptake was 3.3 times and 2.5 times higher than [131I]IMT uptake at 30 min and 60 min, respectively and same after 2 hr in in vitro sutdy using 9L gliosarcoma cells. Maximum accumulation in tumor occurred at 30 min for both [131IOMINT and [131I]IMT in tumor bearing rats. The tumor uptake of [131I]OMINT was significantly higher than that of [131I]IMT in tumor bearing rats. The tumor uptake of [131I]OMIMT was significantly higher than that of [131I]IMT at early time point studied (3.74 +- 0.48 vs 0.38 +- 0.17% ID/g at 30 min and 2.40 +- 0.17 vs 0.24 +- 0.03% ID/g at 2 hr, respectively, p<0.01). However, the tumor uptake of both radiolabels were not significantly different at 24 hr (0.04 +- 0.01 vs 0.05 +- 0.01% ID/g). Tumor was visualized as early as at 30 min in gamma camera images. Conclusion : These data suggested that [131I]OMIMT might be a useful tumor imaging agent and has more advantage for the tumor imaging compared to [131I]IMT. (korean J NuclMed 1998;32;290-7)