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마우스 대뇌감염모델을 이용한 Acyclovir의 항Herpes Simplex Virus Type 1 약효평가
이종교,김해수,Lee, Chong-Kyo,Kim, Hae-Soo 대한미생물학회 1998 Journal of Bacteriology and Virology Vol.39 No.2
To establish in vivo antiviral evaluation system by using murine herpesvirus intracerebral infection model, 5-6 female BALB/c mice per group aged 5 weeks were inoculated i.c. into cerebrum with different inocular HSV-1 F. Signs of clinical disease noted everyday for one month. Observed were body weight decrease, neurological signs and death caused by encephalitis. Mice discontinued body weight decrease were recovered from the disease, and keratitis was often observed during recovery. The groups inoculated with higher than 1,000 PFU showed 100% mortaltiy and $LD_{50}$ was <100 PFU/mouse. To study the effect of virus inoculum sizes on antiviral effect of acyclovir (ACV), mice inoculated with different inocula were administered i.p. with different doses of ACV immediately after infection, and twice a day for 5 days. The higher inculum size, the less protective. $ED_{50}$ of ACV was >25, >25, 18.4 and 8.0 mg/kg b.i.d. in the group infected with 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. $LD_{50}$ of ACV was 62.5 mg/kg b.i.d. Therapeutic index of ACV was <2.5, <2.5, 3.0 and 7.0 in the groups with inocula 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. Inoculum size 1,000 PFU/mouse showing 100% mortaltiy and 5-6 days mean time to death, 5 days drug administration and 14 days observation will be future experimental conditions.
D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),차마리(Ma Rie Cha),신성은(Seong Eun Shin),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Huyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.
L-1,3-Dioxolane 및 L-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),박정하(Jeong Ha Park),송지연(Ji Yeon Song),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Hyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
(+/-)Dioxolane-T and(+/-)BCH-189 are know to possess anti-HIV activities, and less to xicities compared to other dideoxynucleoside AIDS drugs. We have synthesized 34 different enantiomerically pure nucleosides by glycosylation of L-1,3-dioxolanyl acetate and L-1,3-oxathiolanyl acetate sugar moieties with uracil or 6-azauracil with alkyl chains(C1-C3) on 5 or 6 position.
D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
정병호,이종교,김중협,최보길,홍준희,차마리,신성은,정원근,천문우 전남대학교 약품개발연구소 1995 약품개발연구지 Vol.3 No.1
We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.
토양으로부터 HIV 바이러스에 항바이러스 활성을 나타내는 미생물의 탐색
김성욱,이상한,정태숙,문석식,이종교,이항우,이원영,복성해 한국산업미생물학회 1993 한국미생물·생명공학회지 Vol.21 No.5
토양으로부터 분리한 520여 각종 미생물을 대상으로 항 바이러스 활성을 조사한 결과 HSV-1 바이러스에 95% 이상의 저해 활성을 나타낸 것이 6.9%이었으며, 이 시료들은 HSV-2 바이러스에서도 62.1%가 95% 이상의 활성을 나타내었다. 이들중 HIV 항원의 발현이 양성이고 80% 이상의 역전사 효소 활성 저해를 나타내는 2개의 시료를 대상으로 HIV 바이러스에 대한 저해 활성을 조사하여 HIV 바이러스에 강한 저해 활성을 나타내는 8S-301 시료를 선별하였다. For screening of the antiviral agent from soil, about 520 strains of microorganisms were evaluated for their antiviral activity. About 6.9% of strains showed more than 95% antiviral activity against Herpes Simples Virus (HSV)-1. Two strains among 30 strains active against HSV-1 virus showed a quite strong activity against human immunodeficiency virus.