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RISS 인기검색어
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- 저자 : 이정태(Chung Tai Lee):배치운(Chi-Un Pae) (검색결과 2 건)
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주요 우울증에서 Interleukin-10 유전자의 제한효소 절편길이 다형성
전태연,배치운,이정태,박원명,김광수,Jun, Taeyoun,Pae, Chi-Un,Lee, Chung Tai,Bahk, Won-Myong,Kim, Kwang-Soo 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
Objective : Major depression is known to have immunologic dysfunctions, the recent studies revealed that cytokines including IL-6 and IL-$1{\beta}$ were increased in patients with major depression. Since molecular genetic methods have been progressed, this study was to investigate the relationship between major depression and immunologic aspects by analyzing polymorphism of IL-10 gene. Method : 92 patients with major depression were included and data of 146 normal controls obtained from the Catholic Hemopoietic Stem Cell Information Bank of Korea were used in this study. DNA was extracted from whole blood, thereafter amplified by polymerase chain reaction, and digested by Mae III After that procedure, we obtained and assessed RFLP of two alleles, IL-10T and IL-10C. All data were analyzed by ${\chi}^2$ test. Results : 1) There were no significant difference in genotype frequencies of $IL-10^*T/T$, $IL-10^*T/C$, and $IL-10^*C/C$ between major depression patients group and control group. 2) There were no significant difference in allelic frequencies of $IL-10^*T$ and $IL-10^*C$ between major depression patients group and control group. Conclusion : We did not verified the differences in frequencies of $IL-10^*T/^*IL-10^*C$ gene between the major depression patients group and control group, respectively. But the results of this study do not declare that the IL-10 gene has no association with major depression. We do suggest that further systematic studies including various clinical variables should be conducted.
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한국 남성 알코올의존 환자에서의 COMT 유전자 다형성
권용실(Yong-Sil Kweon),이해국(Hae-Kook Lee),이정태(Chung Tai Lee):배치운(Chi-Un Pae) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.1
Catechol-O-Methyltransferase (COMT) is an enzyme which play a crucial role in the metabolism of dopamine. It has been suggested that COMT provide molecular role in development of alcohol dependence because of its genetic polymorphism associated with 3-4 fold variation in enzymatic activity. We carried out an association study to verify the relationship between COMT gene polymorphism and alcohol dependence with violent behavior in Korean population. Ninety seven (97) male alcoholics and 94 male normal controls who did not have history of psychiatric illness were enrolled in this study. After amplifying COMT genes by polymerase chain reaction and assessed genotype and allele by Restriction Frag-ment Length Polymorphism (RFLP). Distribution of COMT genotype and allele frequencies between patients and controls was not significantly different. However, the differences between violent group and nonviolent group were significant in frequencies of COMT genotype (χ 2 =7.977, df=2, p=0.019) and allele (χ 2 = 6.832, df=1, p=0.012). Additionally, the differences between nonviolent groups and controls were significant in frequencies of COMT allele (χ 2 =4.481, df=1, p=0.040). This result suggest that COMT gene polymorphism is not associated with the development of alcohol dependence, but may affect a susceptibility to clinical heterogeneity of alcohol dependence, at least in the Korean population.
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