휴대형 후두 스트로보스콥의 개발

이재우,권순복,이병주,이진춘,고의경,전경명,왕수건,노정훈,Lee, Jae-Woo,Kwon, Soon-Bok,Lee, Byung-Joo,Lee, Jin-Choon,Goh, Eui-Kyung,Chon, Kyong-Myong,Wang, Soo-Geun,Ro, Jung-Hoon 대한후두음성언어의학회 2006 대한후두음성언어의학회지 Vol.17 No.1

Purpose: Evaluation of vocal cord vibration is very important in cases of voice disorders. There are several equipments for examining the vocal fold vibration such as laryngeal stroboscope, ultra high-speed digital imaging system, and videokymograph. Among these, laryngeal stroboscope is the most popular equipment because of easy to examine the laryngeal pathology. However, current laryngo-stroboscopes are too bulky to move and relatively expensive. The purpose of this research is to develope a portable laryngeal stroboscope of equivalent performance with the current equipments. Methods and Materials: Recently developed high luminescent white LEDs(light emitting diodes) are placed at the head of the endoscope as light sources for the CCD image sensor which is also placed at the head with imaging lens. This arrangement eliminates the bulky light source like expensive halogen or xenon lamps as well as the optical light guiding cables. The LEDs are controlled to flash in phase with the voice frequency of the examinee. The CCD captures these strobo images and converts them into video signals for examinations. Results: There was no functional differences between preexisting stroboscope and the newly developed stroboscope of this study. LED light sources and microprocessor based control circuits of the stroboscope enabled the development of flicker-less, hand-held, portable and battery-operating stroboscope. Conclusion: The developed stroboscope is cost-effective, small-sized, easy to use and very easy desirable to bring and to use in any place.

유도무기 통합최적설계를 위한 데이터베이스 설계 연구

이재우,이승진,최석민,조국현,김광식,이정욱,정갑주,Lee, Jae-Woo,Lee, Seung-Jin,Choi, Seok-Min,Cho, Guk-Hyun,Kim, Kwang-Sik,Lee, Jeong-Oog,Jung, Karp-Joo 한국전산구조공학회 2008 한국전산구조공학회논문집 Vol.21 No.6

In this paper, the missile database system for the multidisciplinary design and optimization framework has been designed and investigated. The requirements of the missiles database are analyzed and the database design concept has been defined first. The data flow among the analysis disciplines is investigated and the Entity-Relation diagram is constructed to develop the database table and to define the database schema. The developed database system is integrated into the missile design framework to perform the store, search and management of the design data during the design and analysis of the missile development, hence the efficiency and validity of the database designed in this study has been demonstrated.

QFD(Quality Function Deployment)를 이용한 다목적 헬리콥터의 시스템 설계 요구도 분석

이재우,김민지,박미영,노대홍,Lee, Jae-U,Kim, Min-Ji,Park, Mi-Yeong,No, Dae-Hong 한국시스템엔지니어링협회 2004 시스템엔지니어링워크숍 Vol.4 No.-

용존산소가 SBR 공정에서 질소와 인의 제거에 미치는 영향

이재우,정태학 ( Jae Woo Lee,Tai Hak Chung ) 한국물환경학회 1997 한국물환경학회지 Vol.13 No.1

Effect of Dissolved Oxygen(DO) on the treatment efficiency of wastewater in the Sequencing Batch Reactor(SBR) process was investigated. The peak DO level was maintained below 1㎎O₂/L or above 6㎎O₂/L during the oxic period. Despite low D0, the organic removal efficiency was higher than 95%, but the nitrification was considerably inhibited. This resulted in significant increase in the phosphorus release and improvement of phosphorus removal efficiency. Biological phosphorus removal was accelerated by high organic loading. Large amounts of phosphorus were released during the idle period although there was no influent. When nitrate was used instead of ammonia as a nitrogen source, phosphorus release decreased because of phosphorus uptake at the later part of anoxic period. Polyhydroxyalkanoates(PHA) stored in the cell responded well in accordance with organic availability and phosphorus transport. It is possible to achieve high removal of organic and phosphorus by operation of the reactor at low DO.

상표소와 상심자가 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향

이재우,서부일,박지하,노성수,김용현,김미려,Lee, Jae-Woo,Seo, Bu-Il,Park, Ji-Ha,Roh, Seong-Soo,Kim, Yong-Hyun,Kim, Mi-Ryeo 대한본초학회 2009 대한본초학회지 Vol.24 No.1

본 연구는 상표소와 상심자가 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향에 관한 것으로서 주요 내용은 다음과 같다. 본 연구에서는 상표소와 상심자 물 추출물을 난소를 절제한 흰쥐에 투여하여 대퇴골, 비골경골의 골밀도, 혈청 중 오스테오칼신 함량, 알칼리성 인산가수분해효소 활성도, 칼슘 함량, 인 함량, 소변 중 무기성분의 변화, deoxypyridinoline 함량 등과 뼈의 함량, 인 함량, ash 무게에 미치는 영향을 살펴보았다. 본 실험 결과 상표소와 상심자 물 추출물은 폐경기 이후 골다공증에 대한 치료에 효과적이라고 판단된다는 내용이다.

국제 해커 침투의 대응

이재우,Lee, Jae-U 한국정보통신집흥협회 1997 정보화사회 Vol.114 No.-

미세유체칩내 electrode의 opening window형태에 따른 유전전기영동력 특성 규명

이재우,곽태준,윤대성,이상우,Lee, Jaewoo,Kwak, Tae Joon,Yoon, Dae Sung,Lee, Sang Woo 대한의용생체공학회 2013 의공학회지 Vol.34 No.4

Dielectrophoresis(DEP) is useful in manipulation and separation of micro-sized particles including biological samples such as bacteria, blood cells, and cancer cells in a micro-fluidic device. Especially, those separation and manipulation techniques using DEP in combination of micro fabrication technique have been researched more and more. Recently, it is revealed that a window structure of insulating layer in microfluidic DEP chip is key role in trap of micro-particles around the window structure. However, the trap phenomenon-driven by DEP force gradient did not fully understand and is still illusive. In this study, we characterize the trap mechanism and efficiency with different shapes of window in a microfluidic DEP chip. To do this characterization, we fabricated 4 different windows shapes such as rhombus, circle, squares, and hexagon inside a micro-fluidic chip, and performed micro-sized particles manipulation experiments as varying the frequency and voltage of AC signal. Moreover, the numerical simulation with the same parameters that were used in the experiment was also performed in order to compare the simulation results and the experimental results. Those comparison shows that both results are closely matched. This study may be helpful in design and development of microfluidic DEP chip for trapping micro-scaled biological particle.

Herpes simplex virus-thymidine kinase 유전자가 전이된 종양 세포에서 Gancyclovir와 방사선 조사에 의한 항 종양 효과

이재우,오승택,안창혁,임근우,조현일,김금용,김태규,Lee, Jae Woo,Oh, Seong Taek,Ahn, Chan Hyuk,Lim, Kun Woo,Cho, Hyun-Il,Kim, Gum Ryong,Kim, Tai-Gyu 대한면역학회 2001 Immune Network Vol.1 No.1

Background: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their prodrugs may be promising. A viral enzyme, Herpes simplex thymidine kinase (HSV-tk), which converts ganciclovir from an inactive prodrug to a cytotoxic agent by phosphorylation, are being actively investigated for use in gene therapy for cancer. The purpose of this study was to determine whether combining prodrug-activating gene therapy and irradiation might result in enhanced antitumor effects. Methods: The HSV-tk gene was cloned into the retroviral vector, pLXSN and established the clones producing retroviruses carrying the HSV-tk gene. The carcinoma cell line, HCT116 and Huh-7 were transduced with high-titer recombinant retroviruses. These cell lines were treated with ganciclovir before or after irradiation for the defining combinational effect of suicide gene therapy and radiotherapy. Results: The titers of cloned PA3 17 amphotropic retroviruses ranged from 4 to 6 X $10^6CFU/ml4$. After selectional periods, the expression of HSV-tk was confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR). The growth of cells expressing HSV-tk was inhibited as increase of GCV dose after 48 hr and the growth inhibitory effect of GCV was much higher after 72 hr. When the cells transduced with HSV-tk gene were exposed to radiation, the growth inhibitory effect of GCV was significantly increased, as compared with non-transduced parental cells. Conclusions: The results suggest that the addition of HSV-tk gene therapy to standard radiation therapy may improve the effectiveness of treatment for solid tumors.

세라믹 및 초경합금 성형체의 피절삭성

이재우,Lee, Jae-Woo 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.9

Machining pressed compacts of ceramic and WC-Co materials can be the most cost effective way of forming the bodies prior to sintering when the required number of pieces is small. In this study, in order to clarify the machinability for turning, the $Si_3N_4$ and the WC-Co green compacts unsintered were machined under different cutting conditions with various tools. Absorbing chips by vacuum hose decreases tool wear. The tool wear becomes larger in the order of the ceramic, CBN and cemented carbide tools in machining the $Si_3N_4$ green compacts. In machining the WC-Co green compacts, the tool wear becomes larger in the order of the ceramic, cemented carbide and CBN tools. The land of cutting edge does not affect tool wear. When machining with cemented carbide tool, the tool wear i equal cutting length is nearly identical in spite of the increase of cutting spee, and the roughness of machined surface was the best in the cutting speed of 90 m/min. The tool wear decreases with the increase of rake angle and relief angle and with the decrease of nose radius. The machined surfaces become worse with the increase of feed rate and depth of cut, and with the decrease of rake angle and relief angle. The tool wear is not affected by the feed and depth of cut.

Repetitive single subarachnoid injections for trial administration of the intrathecal morphine pump in patients with intractable non-cancer pain -A case report-

이재우,Kyung Ream Han,Seung-Ho Kim,Ji-Young Lee,Do-Wan Kim,Chan Kim 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.60 No.2

Since the early 1980s, the implantable intrathecal drug pump (ITDP) has been used increasingly to manage chronic pain. Prior to making a decision to implant an ITDP, trial administration of the intrathecal (IT) drug should be performed to estimate the effective dose for a starting set of implantable ITDPs. There is no standard method of trial IT drug administration, though. Therefore, this paper reports 20 cases of IT morphine trial with single and repetitive injections until the appropriate dose was attained with respect to analgesia and its side effects. The trial procedure was performed with daily sequential IT injections using morphine and 0.3% mepivacaine. Twelve out of the total of 20 patients had positive responses. Thus, it is inferred that daily sequential IT morphine injections combined with a placebo injection as a trial ITDP would be useful in evaluating the effectiveness and adverse effects of IT morphine infusion with clinically insignificant side effects.