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동과자가 Glucose Oxidase로 손상된 혈관내피세포에 미치는 영향
서은아 ( Eun A Seo ),최승석 ( Natthew Seung Suk Choi ),이병찬 ( Byung Chan Lee ),이재규 ( Jai Kyoo Lee ),이강창 ( Kang Chang Lee ),정종길 ( Jong Gil Jeong ),신민교 ( Min Kyu Shin ),송호준 ( Ho Joon Song ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objectives : It has been demonstrated that oxidative stress of oxygen radicals is involved in vascular disorder. The aim of this study was to evaluate the cytotoxicity of glucose oxidase (GO) and protective effect of herb extract on GO-induced cytotoxicity in the cultured vascular endotherial cell (VEC) of mouse. Methods : Cytotoxic effect of GO and protective effect of Benincasae Semen (BS) were performed by MTT assay, after cultured VEC were incubated in the media containing 1-30 mU/ml GO for 6 hours. Results : GO decreased cell viability in dose-and time-dependent mannner, and BS increased cell viability decreased by GO-induced cytotoxicity in these cultures. Conclusion : From above the results, GO has cytotoxic effect, and herb extract, BS is very effective in blocking GO-induced cytotoxicity in cultured VEC.
난소암 세포주와 cisplatin 내성주에서의 MDR 관련 유전자의 발현에 관한 연구
문영진(Young Jin Moon),황윤영(Youn Yeung Hwang),이재규(Jai Kyu Lee),나영정(Young Jeong Na),이영미(Young Mi Lee),장성렬(Sung Yeoul Chang),조삼현(Sam Hyun Cho),김경태(Kyung Tai Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
Objective : Expressions of P-glycoprotein, the multidrug resistance-associated protein (MRP) and the lung resistance protein (LRP) with the MDR phenotype widely divergent in human cancer cell lines. This study focused on the altered gene expression related drug transport. Methods : To examine correlations between MDR-associated genes and PKC isozyme with cisplatin resistance on the level of the mRNA expression, we analyzed MDR-associated gene (LRP, MDR1/P-gp and MRP) expression and PKC isozyme, topoisomerase II alpha and beta in cisplatin-sensitive ovarian cancer cell line A2780 and cisplatin - resistant cell line A2780cp using cDNA-PCR approach. Results : LRP mRNA levels were significantly increased in A2780cp compared to the drug sensitive variant. In contrast, MRP mRNA levels were not significantly correlated with drug sensitivity. A modest increase in PKCη and MDR1/P-gp mRNA expression activity was also observed in ovarian cancer A2780cp cell lines that were resistant to CDDP. The level of topoisomerase II alpha and beta were not affected. Conclusion : These results showed that MDR1/P-gp expression may be an important determinant of the MDR phenotype in cell lines intrinsically resistant to cancer chemotherapeutic agents and a multifactorial emergence of MDR phenotype of tumor with a possible involvement of the PKC isozymes may be associated with CDDP resistant ovarian cancer cell line.
이재규,이은미,오석규,손영우,유교상,김상수,이정헌,이강창,한두석,이승현,박승택,김요한,송호준 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
In order to clarify the cytotoxic effect of cadmium in cultured oligodendrocytes of neonatal mouse, the cytotoxicity was measured by MTX assay in cultured cells treated with 1∼20uM CdCl_2 for 24 hours. And also, the protective effect of Achyranthis Bidentazae Radix(ABR) was examined by cell viability in these cultures. Cell viability was significantly decreased in a dose-and time-dependent manner after exposure of cultured oligodendrocytes to 10uM CdCl_2 for 24 hours. Protective effect of ABR on CdCl_2-mediated toxicity was very effective in these cultures. From above the results, it suggests that CdCl_2 is toxic in cultured oligodendrocytes and selective herb extract such as ABR is effective in protection of the CdCl_2 -induced cytoxicity.