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감마 인터페론, LBD-001의 Adjuvant 관절염 억제작용 및 기타 일반 약리작용
이은방(Eun Bang Lee),김제현(Jae Hyun Kim),김운자(Oon Ja Kim),김정근(Jung Keun Kim) 대한약학회 1990 약학회지 Vol.34 No.3
The recombinant gamma-interferon (LBD-001) which was produced by yeast as host system was investigated on the pharmacological activities. This gamma-interferon exhibited potent inhibitory effect on adjuvant induced arthritis, but no effect on carrageenin induced paw edema in rats. It did not show any sedative, anticonvulsive, analgesis and hypothermic activities in animals. It also had no influences on isolated tracheal and ileum of guinea pig, isolated uterus and fundus strip of rats, and on blood pressure and respiration in situ experiments of rabbits.
적출장기표본에 의한 국산생약의 생리활성 검색 (Ⅳ) : 흰쥐의 회장 또는 자궁에서의 항Acetylcholine 및 Oxytocin작용
이은방(Eun Bang Lee) 한국생약학회 1982 생약학회지 Vol.13 No.3
The methanolic extracts of thirty-one medicinal plants were screened for anticholinergic and oxytocic activity in rat`s ileum and uterus, respectively. In addition, their effects on the ileum and antagonism against oxytocin in the uterus were observed.
이은방(Eun Bang Lee),정수연(Soo Youn Chung),이숙영(Sook Young Yi),류항묵(Hang Mook Rheu),승상애(Sang Ae Seung),양지선(Ji Sun Yang),유태무(Tae Moo Yoo) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
These studies were conducted to investigate the antiinflammatory effects and the mechanism of action of natural products. We used the methods of carrageenan induced foot edema , PAF (platelet activating factor) induced foot edema , inhibition test of vascular permeability, inhibition test of white blood cell migration, formation of granuloma and adjuvant induced arthritis to examine the antiinflammatory effects of Angelica gigas, Ledebouriella seseloides, Ginkgo biloba and Bamboo salt (Jukyom). The oral administration of the water extract of Angelica gigantis radix, the methanolic extract of Ginkgo folium and the aqueous solution of Bamboo salt showed antiinflammatory effect on carrageenan and PAF induced foot edema in SD rat at a dose of 1 g/kg. The same administration of methanolic extract of Ginkgo folium also inhibited the vascular permeability in mice. The aqueous solution of Bamboo salt inhibited the formation of granuloma in SD rats at a oral dose of 1 g/kg. Angelica gigantis radix seems to have antiinflammatory effect by inhibition of PAF.
이은방(Eun Bang Lee),장혜옥(Hae Ock Chang),이향주(Hyang Joo Lee),천선아(Seon Ah Cheon) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2
General pharmacological properties of recombinant human parathyroid hormone (hPTH) were examined. The administration of hPTH (7, 35 and 175 IU/kg sc) in mice had no effects in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazol solution. hPTH (9 and 44 IU/kg, sc) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration, and it did not influence the responses produced by injection of acetylcholine or epinephrine. It showed no direct effect at 4.4 x 10^(-2) IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also showed no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence intestinal propulsion at the doses of 7, 35 and 175 IU/kg sc in mice. This drug exhibited no effect on urinary excretion at the doses of 7 and 35 IU/kg sc in rats. However, at a dose of 175 IU/kg sc, it showed a decreased urination along with decreased excretion of potassium, sodium and chloride ion. These results indicate that hPTH does not exert any of serious pharmacological effects except the inhibition of urination at a highest dose used.
유전자 재조합 Erythropoietin (LB-00014) 의 일반약리작용
이은방(Eun Bang Lee),천선아(Seon Ah Cheon),이향주(Hyang Joo Lee),조성익(Sung Ig Cho),손지영(Jee Young Sohn) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/㎏, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/㎏, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephrne. The administration of LB-00014 (601, 600, 6000 IU/㎏, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 IU/㎏, iv). It showed no direct effect at 100 and 1000IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/㎏, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/㎏, iv. Its administration (60, 600, 6000 IU/㎏, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.
콜레스테롤과 비타민 D2 첨가 사료로 유도된 흰쥐의 고지혈증에 대한 Taurine의 효과
이은방(Eun Bang Lee),김옥경(Ok Kyung Kim),정춘식(Chun Sik Jung),김주선(Ju Sun Kim) 大韓藥學會 1997 약학회지 Vol.41 No.4
Antihyperlipidemic effect of taurine was investigated in the hyperlipidemic rats induced by feeding a diet supplemented with cholesterol (1.5% in diet), vitamin D2(1.25 million IU/kg of diet) and cholic acid (0.5% in diet). The rats were fed the diet containing 1% and 3% of taurine for 8 weeks. The contents of the cholesterol and triglycerides in the serum and liver of the hyperlipidemic rats were increased as compared with those of the control group. Feeding taurine resulted in decreases in total cholesterol and triglyceride levels. The HDL-cholesterol level in serum was decreased in the hyperlipidemic rats, but by administration of taurine its level was increased. In the aorta of the animals, total cholesterol and triglycerides contents were reduced significantly by treatment with taurine. The contents of calcium in the heart of hyperlipidemic rats were greatly increased as compared with those of the control group. Treatment of taurine produced significant decreases in calcium contents in the heart muscle of the animals. These results showed that the hyperlipidemic states in this model of rats were reversed by treatment of taurine.
이은방(Eun Bang Lee),조성익(Sung Ig Cho),이대위(Da Wei Li),현진이(Jin Ee Hyun) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.3
N/A DKY is an oriental drug preparation composed of 17 natural products and is known to have antihyperglycemic action at 100 ㎎/㎏ po in animal tests. The general pharmacological properties of DKY preparation were investigate in mice, rats, guinea pigs and rabbits. This preparation did neither show any effects on central nervous system, nor effects on algesia, nor epilepsia at the large doses of 3000 ㎎/㎏ po in mice or rats. However, the preparation showed hypothermic action at the doses of 330 and 1000 ㎎/㎏ po. In the guinea pig ileum, rat fundus strip and estrogenized rat uterus, DKY did not influence their tension at a concentration of 3 X 10^(-3) g/㎖, and the spasmogenic actions produced by histamine, ACh and 5-HT were not blocked in the presence of DKY at 3 × 10^(-3) g/㎖. The blood pressure and respiration were not considerably influenced at 10㎎/㎏ iv of DKY in rabbits. It did not influence the intestinal propulsion of mice and the normal gastric secretion of rats. These results may suggest that DKY preparation have little effects on central nervous, autonomic and gastrointestimal systems, except hypothermic action.
이은방(Eun-Bang Lee) 한국생약학회 1982 생약학회지 Vol.13 No.3
In order to investigate the side-effects of crude drugs, twenty drugs have been tested for the teratogenic effect in rats. Among seven drugs contained alkaloid as their ingredients, no one showed teratogenic effect, but Veratri rhizoma showed embryotoxic as revealed by severe retardation in growth of the fetuses. The other thirteen drugs which have been used freguently in oriental medicines exhibited no teratogenic effect. Cyclophosphamide used as a reference compound showed severe malformation and retardation in the growth of rat fetuses. These findings suggest that the drug extracts adopted for the study might have no teratogenic effect in the rats.
소형선박의 충돌사고예방을 위한 초음파 경보시스템 개발에 관한 기초 연구
이은방(Eun Bang Lee) 한국해양대학교 해사산업연구소 2004 海事産業硏究所論文集 Vol.15 No.-
A ultrasonic alert system is proposed in order to prevent the collision accidents of small ships. This system displays a lamp and a sound signal alerting collision by transmitting ultrasonic pulse in air to detect ships and objects within 50 m. Under the condition of restricted visibility and complicated works, it is expected to enhance the effect of navigators' lookout.