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Omeprazole-cholestyramine Resin 직장투여와 정맥주사시의 토끼에 대한 약물 동력화 연구
이영욱,우종수,김진학,이율표,조성호,금찬,성지현,임성혁,손의동,허인회 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-
We have performed the pharmacokinetic study of omeprazole- cholestyramine resinate in rabbits, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. In this experiments, omeprazole-cholestyramine resinate suppository seemed to have more rapid absorption than omeprazole. AUC and C_max of omeprazole-cholestyramine resinate were 2.3 and 3.7 times greater than omeprazole, respectively. T_max was almost half of omeprazole. Compared with i.v. bolus, i.v. infusion showed three times greater bioavailability. As a result omeprazole-cholestyramine resinate suppository had 74% bioavailability of i.v. infusion, suggesting i.v. infusion could be replaced by suppositories.